Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A quantitative comparison was made of the effect of infiltration of local analgesics and topical analgesic cream (EMLA) on laser-induced pain and histamine-induced wheal, flare and itch. Wheal and flare were quantified by planimetry and analgesia was quantified by the pricking pain threshold to argon laser stimulation. The intensity of histamine-induced itch was scored on a 4-point scale. Local analgesics had no effect on the wheal area. The flare reaction was abolished by infiltrating lignocaine, and gradually inhibited by increased application times of EMLA. Itch was abolished after local lignocaine infiltration, but not significantly reduced after EMLA cream applied for less than 120 min, although the skin was anaesthetized to laser-induced pain. The reduction of flare area correlated to the level of analgesia, which may therefore reflect the cutaneous responsiveness to neurogenic inflammation. It is suggested that itch and pricking pain are mediated by different populations of nerve fibres, as itch can be evoked even when the sensation of pricking pain is abolished. Surgery, skin prick tests and other traumatic procedures should therefore be performed under local anaesthesia to reduce neurogenic inflammation.
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PMID:A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. 196 96

Needle biopsies are being performed commonly as a substitute for open biopsy in certain patients in whom a tissue diagnosis is necessary to determine therapy. During the last few years the Biopty gun and its through-cut needle have evolved as a satisfactory method to perform prostate biopsy in a rapid and painless manner. To determine whether the Biopty gun could be used to perform testicular biopsies 7 patients underwent this procedure in an outpatient setting. The patients received cutaneous lidocaine and the special through-cut needle (already inserted in the gun) was inserted painlessly through this cutaneous wheal towards the tunica albuginea of the testis. The gun was fired and in less than a fraction of a second a biopsy was obtained. The needle was removed and the tissue was placed in Bouin's solution. In some patients more than 1 biopsy was performed. None of the biopsies took more than 5 minutes, none of the patients required postoperative analgesia and none felt untoward discomfort during the biopsy. All biopsies obtained adequate tissue to diagnose the presence of sperm. These results demonstrate that needle biopsy of the testis with the Biopty gun system is a cost-effective, rapid, safe, relatively harmless and effective way to obtain a testicular biopsy to identify the presence of sperm. With time this percutaneous method may supercede other open and percutaneous methods of testicular biopsy.
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PMID:Use of biopty gun for transcutaneous testicular biopsies. 279 23

We report the first case of envenomation by the billygoat plum stinging caterpillar, Thosea penthima Turner (Limacodidae). The sting, on the forearm, caused immediate burning pain and local wheal formation. Pain radiated up the arm and there was severe "crushing" chest pain lasting four hours. The local pain persisted for 10 hours and required opiate analgesia.
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PMID:Envenomation by the billygoat plum stinging caterpillar (Thosea penthima). 1137 21

The purpose of this study was to determine whether paraspinal field block (PSFB) reduced the pain of epidural needle insertion and the incidence of prolonged post partum back pain in patients receiving epidural analgesia for labour. Patients were randomly assigned to receive local infiltration only with 1-1.5 ml of 1.5% lidocaine (group C, N = 27) or PSFB consisting of an additional 1 ml of 1.5% (group S, N = 30) through the midline skin wheal, on either side of the midline (total 2 ml), near the lamina, before needle insertion. Back pain was measured at the time of needle insertion, before discharge from hospital and 6 weeks post partum, by a blinded observer. There were no differences between groups in maternal or neonatal demographic data. There was no difference in back pain at any of the times measured. The incidence of severe back pain 6 weeks post partum was 0% in group C and 6.6% in group S (combined incidence group C+group S = 3.5%). The cause of post partum back pain is multifactorial and is not dependent on technique of epidural insertion. We conclude that PSFB is ineffective in reducing the pain of epidural needle insertion in labouring patients. Although this study was too small to detect a difference in incidence of late post partum back pain, it appears to be less common than previously reported.
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PMID:The use of a paraspinal field block before epidural analgesia for labour. 1563 9