Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A comparison of two non-steroidal anti-inflammatory drugs (NSAIDs), ketorolac and diclofenac, indicates both were relatively ineffective for treating pain after laparoscopic sterilization. NSAIDs produce analgesia by inhibiting the synthesis of prostaglandins. Patients were randomly assigned to receive intramuscular injections of either 75 mg of diclofenac (n = 25) or 30 mg of ketorolac (n = 25) 30-90 minutes before surgery. There were no major anesthesia or surgical complications. The median duration of surgery, time from initial dose of NSAID to arrival in the recovery room, and length of stay in the recovery room were 20, 75, and 60 minutes, respectively, in both groups. Only 4 women in the diclofenac group and 5 in the ketorolac group did not require further analgesia after surgery, but 60% had adequate analgesia after a second NSAID dose. Pain scores, postoperative nausea and vomiting, and the requirement for anti-emetics did not differ between groups. Injection site pain lasted 15-30 minutes after ketorolac compared with 8-12 hours after diclofenac. While the analgesic potency of ketorolac is about 5 times that of diclofenac, the anti-inflammatory potency of ketorolac is only twice that of diclofenac.
 ...
PMID:A comparison between ketorolac and diclofenac in laparoscopic sterilization. 866 83

This double-blind pilot study compared the local anaesthetic effects of tramadol plus adrenaline with lidocaine plus adrenaline during surgery to repair hand tendons. Twenty patients were randomly allocated to receive either 5% tramadol plus adrenaline (n = 10) or 2% lidocaine plus adrenaline (n = 10). Injection site pain and local skin reactions were recorded. At 1-min intervals after injection of the anaesthetic agent, the degree of sensory blockade was assessed by the patient reporting the extent to which they felt a pinprick, light touch and a cold sensation. Pain felt during surgical incision was also recorded. There was no difference in the quality of sensory blockade or the incidence of side effects between the two groups. Only patients treated with tramadol did not require additional post-operative analgesia. A combination of tramadol plus adrenaline provided a local anaesthetic effect similar to that of lidocaine plus adrenaline.
 ...
PMID:Tramadol as a local anaesthetic in tendon repair surgery of the hand. 1883 90