Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study was undertaken in order to investigate the analgesic effect of needle puncture in a small self-selected group of patients with chronic or acute pain, and to examine the factors which determine success or failure of this treatment modality. We have found that in chronic painful conditions, needle puncture may be very effective in producing at least transient analgesia. It also can produce permanent relief of acute (self-limited) pains. Needle puncture was not helpful in the management of pain resulting from nerve damage. High score on psychometric indicators of anxiety and depression is a significant predictor os successful needle puncture analgesia in patients with chronic pain. Comparison of our results to studies of counterirritation indicate that the analgesia produced by needle puncture involves a mechanism similar to that of counterirritation-induced analgesia.
Pain 1976 Jun
PMID:Observations on the analgesic effects of needle puncture (acupuncture). 14 Oct 19

(1) The characteristics of an analgesia which can be elicited in rabbits by electrically activated acupuncture needles are described. (2) The analgesia can be reversed by systemic administration of the inhibitory amino acid antagonists bicuculline or strychnine. (3) Pharmacological procedures which interfere with tryptaminergic mechanisms, or destruction of the dorsal raphe nuclei, prevent the development of analgesia. (4) It is concluded that the production of analgesia probably depends upon postsynaptic inhibition of the transmission of afferent information from nociceptors, and at more than one site in the central nervous system.
Pain 1977 Jun
PMID:Some pharmacological observations on the analgesia induced by acupuncture in rabbits. 14 45

In 387 pat., we observed the interdependence of abnormal vertebral column and failures in epidural anaesthesia by medial tap with the "los of resistance" method. We could show that in contradistinction to other opinions scoliosis induces no higher rate of failure of epidural anaesthesia than the normal vertebral column. In patients with kyphoscoliosis and ossified ligaments the epidural space was identified less frequently than in the normal group, perforations of the dura were encountered more frequently. These results are statistically significant. In patients who had or have pain in the back (p.e. lumbago) and those with ossified ligaments we found significantly more pain during operation although analgesia was tested before. In these three abnormalities of the vertebral column we recommend to judicously balance advantages against disadvantages of epidural anaesthesia and alternative anaesthetic procedures.
 ...
PMID:[The influence of abnormal vertebral column on failure in epidural anaesthesia (author's transl)]. 14 69

Cordotomy should be reserved for patients with intractable pain resistant to conservative treatment that is not of a dysaesthetic type. The high cervical percutaneous technique permits exploitation of the principles of stereotactic surgery, especially physiological localization of the lesion site. The induction by 100 Hz stimulation of a warm or cool tingling in some portion of the contralateral half of the body without muscle tetanization ensures location within the spinothalamic tract while attention to the somatotopographic organization of the responses permits a certain degree of tailoring of the extent of analgesia to the patient's needs. During 264 consecutive procedures the spinothalamic tract was successfully located in 99% with a 0.3% incidence of significant persistent paresis.
 ...
PMID:Percutaneous cervical cordotomy. 14 48

The incidence of the postpartum sequelae of headache, backache, pain in the legs and difficulties in micturiton, was studied in 219 normal vaginal deliveries. 135 of the parturients received continuous segmental epidural analgesia at the level of Th 10--12 for pain relief during the first stage of labour. The remaining 84 parturients served as controls. The results showed that segmental epidural analgesia did not increase the occurrence of postpartum sequelae either in primiparous or in multiparous parturients.
 ...
PMID:Segmental epidural analgesia and postpartum sequelae. 15 Feb 49

A mechanical noncoagulation obliterative technique - Falope ring or Silastic band - was used for laparoscopic tubal sterilization on 224 patients at the Brookdale Hospital Medical Center for July 1, 1976 through december 31, 1977. Hysterosalpingography under fluoroscopic guidance using Ethiodol was performed on 97 patients, 5-11 months after surgery, and observation laparoscopy was performed on 7 patients, 8-12 months after the initial operation. Tubal transection occurred 15 times in 12 of 224 patients (5.4%). Management included banding, coagulation, and both coagulation and banding. Pain requiring analgesia on the 1st postoperative day or requiring a prescribed analgesia at home was present in 14 patients (6.7%). Infection appeared as salpingitis-peritonitis in a patient whose IUD was removed immediately prior to banding. Pregnancy occurred in 2 patients. The incidence of complications was low.
 ...
PMID:Silicone band sterilization with radiographic and laparoscopic evaluation. 15 20

As far as we know, this is the first scientific report which shows distinctly that acupuncture is transmitted directly by the nervous system and the performance of analgesic acupuncture requires an intact nervous system. The more distal the acupuncture treatment is given upon the nerve, the greater the degree of analgesia is afforded. The slowing from a normal awake beta to a normal awake alpha electroencephalographic rhythm may have some effect on the patient's pain perception but further investigation is required.
 ...
PMID:Pathophysiology of acupuncture: nervous system transmission. 16 10

Three modulating mechanisms of the "gate-control theory" provide a plausible explanation of how acupuncture analgesia works. In particular, the inhibitory effects of the brainstem reticular formation on the transmission of pain signals in the spinal cord or at higher ttransmission levels seems to provide a powerful explanatory concept. Intense stimulation through acupuncture needles could activate this inhibitory brainstem system, thereby closing the gate to pain signals.
 ...
PMID:[Acupuncture and pain mechanisms (author's transl)]. 18 60

Narcotic analgesics and related drugs act as agonists on several receptors that are responsible for their effects on pain perception, mood and feeling state, and respiration, as well as other pharmacologic actions. Naloxone is the first discovered antagonist that is devoid of agonistic activity and appears to be a competitive antagonist at several receptors. The ability of naloxone to displace or prevent the binding of agonistic narcotics is partly responsible for its antagonistic effects. The ability of naloxone to rectify narcotic-depressed homeostats and precipitate abstinence is also related to its antagonistic activity. Certain cautions and principles apply in the use of naloxone in treating narcotic overdose, reversing surgical analgesia, and the treatment of neonates and children. Unapproved uses of naloxine include reversing the psychotomimetic effects of certain agonists-antagonists, terminating narcotic-induced convulsions and coma, reversing non-narcotic depression, diagnosing physical dependence, and treating narcotic addicts.
 ...
PMID:Naloxone. 18 95

Maternal plasma ACTH, cortisol and TSH concentrations were determined during the course of the induced labours of 20 normal parturients. Alternate mothers were given segmental epidural analgesia for pain relief during the first stage of labour. The remaining parturients served as controls. The ACTH level rose in same way in both groups, reaching its peak at the moment of delivery and decreasing rapidly thereafter. Cortisol secretion reached its maximum during the first stage of labour in the moment of delivery. After delivery the cortisol level decreased more rapidly in the epidural group tha. in the control gro,p. Umbilical venous cortisol concentration was the same in both groups. The maternal TSH level did not change significantly during labour in either group.
 ...
PMID:The effect of segmental epidural analgesia on maternal ACTH, cortisol and TSH during labour. 18 74


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>