Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of catecholaminergic A-1 lateral reticular nuclei and serotoninergic neurons of NRM on pain reactions before and after various types of stimulation are presented. It was established that specific lesions of catecholaminergic (NE) neurons in A-1 nuclei using 6-hydroxydopamine, and of serotoninergic (5-HT) neurons of the nucleus raphe magnus using 5,7-dihydroxytryptamine caused a decrease in the respective levels of epinephrine and serotonin in the spinal cord. The baseline pain sensitivity did not change following surgery. Analgesia induced by cold swimming stress (CSS), auricular electroacupuncture (AEA) and vaginal probe (VP) was less in A-1-lesioned rats. Using stimulation of high intensity, such as CSS and VP, a decrease in pain sensitivity was determined, compared to the baseline. The AEA did not produce such an effect. The data obtained suggest that catecholaminergic systems of A-1 play an important role in pain regulation when CSS, AEA and VP are used. Other neurochemical mechanisms, as well as A-1 nuclei systems, are involved in analgesia, induced by CSS and VP. It was shown that lesion of 5-HT-ergic systems of NRM did not have any influence of antinociceptive mechanisms, when activated by AEA and VP.
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PMID:A study of the catecholaminergic systems of the lateral reticular nuclei and the serotoninergic systems of the raphe magnus in various types of analgesia. 631 78

Experiments were made on rats in which the effects of catecholaminergic neuronal systems of lateral reticular A-1 nuclei were eliminated with 6-OHDA. The latency of pain reactions tested by the hot-plate and tail-flick tests remained unchanged after operation. After auricular electric acupuncture the rats manifested no changes in the above reactions as compared with the initial level, which evidences that A-1 nuclei play an important role in the mechanisms of analgesia under consideration. Stimulation of the small pelvis organs (SSPO) entailed a short-term and significant inhibition of the analgetic effect as regards the control which also points to the involvement of A-1 nuclei into activation of antinociceptive processes. Besides, during SSPO, there was a significant elevation of the response measured by the tail-flick test as compared to the initial level of the pain reaction.
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PMID:[Role of catecholamine neurons in the reticular lateral nuclei in regulating sensitivity to pain during exposure to reflex stimuli]. 640 22