Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fuel preference of human muscle mitochondria has been given. Substrates which are oxidized with low velocity cannot be used to detect defects in oxidative phosphorylation. After general anaesthesia, the oxygen uptake with the different substrates is much lower than after local analgesia. The latter was therefore used in the subsequent study. In 15 out of 18 patients with ocular myopathy, defects in oxidative phosphorylation could be detected in isolated muscle mitochondria prepared from freshly biopsied tissue. Measurement of the activity of segments of the respiratory chain in homogenate from frozen muscle showed no, or minor defects. In two of these patients showing exercise intolerance, decreased oxidation of NAD(+)-linked substrates and apparently normal mitochondrial DNA, further study revealed deficiency of pyruvate dehydrogenase in a girl with ptosis and a high Km of complex I for NADH in a man. Both patients responded to vitamin therapy.
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PMID:Oxidative phosphorylation in human muscle in patients with ocular myopathy and after general anaesthesia. 211 84

Creative approaches, such as NAD, can be taken to manage pain in patients who would be candidates for PCA therapy if they were physically and cognitively able to manage their own pain. NAD authorizes the patient's primary nurse to administer bolus doses with or without a basal rate via the PCA infusion pump. Doses are administered for breakthrough pain with a basal rate or in scheduled doses to maintain analgesia without a basal rate. It is also used to administer bolus doses before and during painful procedures.
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PMID:Unconventional use of a PCA pump: nurse-activated dosing. 2561 91