Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper concerns the anesthetic aspects of safe conscious sedation and dental treatment of patients with metabolic syndrome. BIS monitoring in combination with routine pulse oximetry and blood pressure measurement is getting dental sedation safer. Independently of the bolus or continuous intravenous midazolam infusion the investigators approved high efficacy of bispectral index in benzodiazepine dose titration. Successful dental treatment under conscious sedation and no evident associated with analgesia complications show the importance of BIS-monitoring in the improvement of safe sedation and dental treatment in patients with metabolic syndrome.
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PMID:[The improvement of safe sedation and dental treatment in patients with metabolic syndrome]. 2243 38

Protocatechuic acid is a natural phenolic acid, which widely exists in our daily diet and herbs. It is also one of the main metabolites of complex polyphenols, such as anthocyanins and proanthocyanins. In recent years, a large number of studies on the pharmacological activities of protocatechuic acid have emerged. Protocatechuic acid has a wide range of pharmacological activities including antioxidant, anti-inflammatory, neuroprotective, antibacterial, antiviral, anticancer, antiosteoporotic, analgesia, antiaging activties; protection from metabolic syndrome; and preservation of liver, kidneys, and reproductive functions. Pharmacokinetic studies showed that the absorption and elimination rate of protocatechuic acid are faster, with glucuronidation and sulfation being the major metabolic pathways. However, protocatechuic acid displays a dual-directional regulatory effect on some pharmacological activities. When the concentration is very high, it can inhibit cell proliferation and reduce survival rate. This review aims to comprehensively summarize the pharmacology, pharmacokinetics, and toxicity of protocatechuic acid with emphasis on its pharmacological activities discovered in recent 5 years, so as to provide more up-to-date and thorough information for the preclinical and clinical research of protocatechuic acid in the future. Moreover, it is hoped that the clinical application of protocatechuic acid can be broadened, giving full play to its characteristics of rich sources, low toxicity and wide pharmacological activites.
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PMID:New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily. 3273 94