Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cytotoxic chemotherapy does not yet have a service role in the management of invasive carcinoma of the bladder, though the minor palliation achievable in patients with symptomatic recurrent primary or metastatic disease does justify its use in patients whose symptoms are not controlled by standard analgesia. For the future, progress will depend on more intense screening of new drugs in centres specializing in undertaking Phase 2 Trials on patients with measurable metastases. However, there is in addition a need for studies measuring primary tumour response to drugs in combination with radiotherapy which still remains the most active single agent in the non-surgical treatment of carcinoma of the bladder.
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PMID:Chemotherapy of invasive carcinoma of the bladder. 386 78

The past few years mark an ever increasing interest in intravesical obstructions in urological practice. After clarifying issues relating to the role and type of the underlying disease leading to intravesical obstruction, 173 patients with such a condition, subjected to analgesia of varying type, are analyzed under the aspect of anesthesiology. In 98 cases (56.65 percent) the underlying cause of obstruction is adenoma of the prostate gland, in 60 men and 9 women (39.88 percent)-carcinoma of the bladder, and in eight patients (3.47 percent)-sclerosis of the prostate gland. Preparation of the patients for anesthesia and operation is greatly interfered with by the concomitant polymorbidity, insofar as 83.5 percent of the contingent are older than 60 years of age. Analgesia is secured by endotracheal anesthesia (96 cases), epidural analgesia (64) and spinal-epidural analgesia (13). A comprehensive analysis based on the type of anesthesia and condition of the patient during operation is done, leading to the inference that all three methods are individually indicated.
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PMID:[Anesthesia problems in patients with an infravesical obstruction]. 864 65