Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Volatile oil exhibited depressant effect on central nervous system of rats and mice. It blocked CAR in 80% animals and potentiated effects of chlorpromazine hydrochloride on CAR and pentobarbitone induced hypnosis in mice. It exhibited hypothermic and analgesic activities and potentiated morphine induced analgesia considerably. The volatile oil checked tonichind limb extension produced by electric shocks but failed to check strychnine and mentrazol induced convulsions The antipyretic activity of the volatile oil was not significant.
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PMID:Pharmacological investigations of volatile oil of cyperus eleusinoides kunth effect on central nervous system. 2255 91

Aminoglycosides (AGs) modulate nociceptors and ionic channels expressed in sensory neurons. The AG applied in situ could be useful to alleviate hyperalgesia in animal models of inflammatory pain. We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration. The action of ST and NEO on the action potential discharge produced by acidic stimuli in isolated dorsal root ganglion neurons was also studied in current-clamp recordings. In the formalin test, ST and NEO significantly reduced the nociceptive behaviour. ST reduced the N-(4-methyl-2-quinazolinyl)-guanidine (GMQ)-induced nociceptive behaviour, and NEO diminished the hyperalgesia to thermonociception and mechanonociception produced by CAR. In the current-clamp experiments, ST and NEO reduced the generation of action potentials when an acidic solution was applied. We conclude that ST and NEO produce analgesia to inflammatory pain, an effect that is due in part to the inhibition of ASIC activation in sensory neurons.
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PMID:Inhibition of peripheral nociceptors by aminoglycosides produces analgesia in inflammatory pain models in the rat. 2502 2