Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the hypothesis that inhalation of low levels of nitrous oxide-oxygen produces an altered state of consciousness similar to hypnosis, 20 subjects were given three suggestions (analgesia, compulsive behavior, and amnesia) during double-blind administration of either nitrous oxide-oxygen or oxygen. Results suggest that administration of nitrous oxide-oxygen may be of increased clinical usefulness if it is combined with careful use of suggestion.
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PMID:The relationship between nitrous oxide conscious sedation and the hypnotic state. 29 18

Monkeys chronically attack the hypoalgesic hindlimb after thoracic contralateral anterolateral cordotomy or hemisection. This compulsive behavior could be induced by innocuous stimulation in the hypoalgesic region, and it also appeared to occur spontaneously. The postcordotomy spontaneous compulsive self-directed behavior was studied in 4 macaques after subsequent upper lumbar crush spinal transection. Despite the paraplegia and bilateral analgesia/anesthesia, this spontaneous abnormal behavior continued to be directed to the same hindlimb as before transection, but not to the opposite hindlimb. Hence, it is concluded that the recurring syndrome originated from the initial contralateral cordotomy. The rationale for the presumption of postcordotomy spontaneous dysesthesias is presented, and the experimental results are offered in refutation of alternative interpretive hypotheses. In conjunction with previous findings, these results lead to the argument that postcordotomy dysesthesias are caused by a neuropathological compensatory response to partial deafferentation of brain somatosensory neurons.
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PMID:Postcordotomy spontaneous dysesthesias in macaques: recurrence after spinal cord transection. 270 66

This paper reviews the concept of repetition compulsion (RC) from Freud's original formulation to recent contributions from psychoanalysis and the neurosciences. Literature on RC presented four major controversies: (1) Does RC describe a broad range of dysfunctional repetitive behaviors, or only the repetition of severe traumatic experiences? (2) Is RC an attempt to achieve mastery and control of a traumatic experience, or to reach a particular psychic state as analgesia or excitement, which reduces the perception of emotional pain? (3) Is the death instinct an acceptable explanation for RC? (4) Is RC a useful, meaningful, and specific concept? The author describes his personal perspective on RC which integrates psychodynamic and biological contributions. Clinical material is provided.
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PMID:Repetition compulsion in a trauma victim: is the "analgesia principle" beyond the pleasure principle? Clinical implications. 1545 84

Autism spectrum disorder is a debilitating mental illness and social issue. Autism spectrum disorder patients suffer from social isolation, cognitive deficits, compulsive behavior, and sensory deficits, including hyposensitivity to pain. However, recent studies argued that autism spectrum disorder patients show physiological pain response and, in some cases, even extremely intense pain response to harmless stimulation. Recently, Shank gene family was reported as one of the genetic risk factors of autism spectrum disorder. Thus, in this study, we used Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.
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PMID:Reduced acute nociception and chronic pain in Shank2-/- mice. 2714 3