Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because preoperative cervical dilatation is advantageous, especially in nulliparous subjects, dilatation before vacuum aspiration was achieved by a single intramuscular dose of 500 mcg of 16 phenoxy delta 17,18,19,20 tetranor prostaglandin (PG) E2 methyl sulfonylamide. 80 first trimester nulliparas, aged 15-34, were pretreated 3 hours before uterine evacuation with the PG analog. None of the 80 aborted during the interval between PG injection and uterine evacuation, but 25 (31%) had some uterine bleeding. In 24 of these 25, bleeding was slight ( 10 ml), and it was moderate in the other (25-50 ml). 3 hours after PG administration, the degree of cervical dilatation ranged from 4-14 mm. 60 patients (75%) achieved adequate dilatation (8 mm or more), allowing for complete uterine evacuation without mechanical dilatation. 17 patients whose cervices had dilated 6-7 mm had slight further dilatation which was easily performed. The cervix failed to dilate beyond 4 mm in 3 subjects, and mechanical dilatation proved difficult. Uterine pain was reported by all subjects. Complications (through 4-weeks follow-up) were not evident. Side effects were those common to PG, i.e., vomiting, transient pyrexia 1 degree centigrade, and pain requiring analgesia. The time interval between PG injection and adequate cervical dilatation was short enough to avoid overnight hospitalization and seems an efficacious outpatient procedure.
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PMID:Intramuscular administration of 16 phenoxy omega 17,18,19,20 tetranor PGE2 methyl sulfonylamide for pre-operative cervical dilatation in first trimester nulliparae. 71 49