Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have previously demonstrated that during acute arthritis in the rats induced by local intraplanter adjuvant, there are dramatic alterations in the behavioral responses to noxious stimulation. The purpose of this study was to observe the changes in responses of parafascicular nuclei (Pf) neurons during acute arthritis and effect of acupuncture (EA) in the rats. It was shown that: (1). for the whole populations of somatosensory neurons there was no statistical significant between arthritic rat and normal rat (P greater than 0.05). However, nociceptive neurons activated exclusively by noxious stimulation were less in the arthritic rat (21/60) than in the normal rat (35/46) (P less than 0.01); nociceptive-non-nociceptive neurons activated by both noxious and non-noxious stimulation were more in the arthritic rat (30/60) than in the normal rat (9/46) (P less than 0.01), and there was no statistical significant different for population of non-nociceptive neurons between two groups. (2). Nociceptive responses of Pf neurons (n = 16) could be markedly inhibited by EA at Xuanzhong (G39) and Kunlun (B60) in acute arthritic rat. In particular, the inhibitory effect was of great significance (P less than 0.01) during 0-10 and 20-35 minutes following cessation of EA. These results suggest that rats were hyperalgesic during adjuvant-induced acute arthritis and EA produces a fine analgesic effect in acute arthritic rats. The results also support the view that adjuvant-induced acute arthritic rat can be considered as a model for research of pain and analgesia.
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PMID:[Changes in responses of parafascicular nuclei during adjuvant-induced acute arthritis and effect of acupuncture in the rat]. 211 12

Our previous work has shown that opiate-like substance (OLS) is involved in the central mechanism of acupuncture analgesia (AA) in the arthritic rats. In this paper, the role of OLS in peripheral mechanism of AA is further studied. Twenty four hours after a subcutaneous injection of Freund's adjuvant into the right ankles, acute arthritis with typical symptoms developed in all the rats. Following needling at Huantiao points for 10 minutes, the pain threshold (PT) was raised by 42.3% (P < 0.05) in the inflamed ankles and by 5.6% in the non-inflamed ones. When systemically administered a dose of 250 and 100 micrograms, naloxone (Nx) could completely and partially (49.6%) block AA respectively. While locally injected a dose of 100 micrograms even 20 micrograms, Nx could completely antagonize AA. After systemic administration of morphine (10, 5.0, 2.5, 1.25 mg/kg), PT rise was dose-related, and PT was raised by 86.5 +/- 22.7% in the affected ankles and by 32.9 +/- 14.9% in the normal ankles at 5 mg/kg in dose. It is evident that the opiate receptors in the inflamed area should by sensitized. These results demonstrate that activation of endogenous opiate system may also be involved in the peripheral AA. Acupuncture may enhance the release of peripheral OLS which can act at the sensitized opiate receptors, leading to more potent analgesic effect in the inflamed area.
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PMID:[The role of OLS in peripheral acupuncture analgesia in arthritic rats]. 792 19