Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many drugs potentiate the action of non depolarizing relaxants. These interactions are of clinical importance if such drugs are administered during the perioperative period. H2 Antagonists are increasingly often used for premedication. Cimetidine inhibits the elimination of a number of drugs used in the perioperative period. We therefore investigated whether H2 antagonists enhanced neuromuscular blockade by vecuronium, a medium short acting non depolarizing muscle relaxant. METHODS. The study was carried out in 24 female patients (ASA class I or II) scheduled for microsurgical procedures. Neuromuscular transmission was recorded electromyographically using four stimulations every 20 s to the ulnar nerve. After induction with thiopentone, anesthesia was maintained with fixed concentrations of volatile anesthetics. Fentanyl was administered for additional analgesia. Vecuronium was used as the sole muscle relaxant. Fixed repetitive doses of vecuronium (0.8-1.2 mg) were injected whenever the T1 returned to 25%. This time interval was defined as the T1-25 period. The study proper started when the T1-25 period had stabilized. After two control periods, six patients in each group received either 200 or 400 mg cimetidine or 100 mg ranitidine. The fourth group was the control group. The T1-25 periods and the maximal EMG depression were recorded automatically for at least two further periods. The first measured period was recorded as 100% and the length of each other periods was calculated as a percentage of the control period. This method enables an intraindividual comparison of the length of the T1-25 period and the maximal EMG depression before and after administration of the H2 antagonists. A two-tailed Student's t-test was used to test statistical significance, P less than 0.05 being accepted as significant. RESULTS. In the control group and in the group with 200 mg cimetidine or 100 mg ranitidine no statistical significant prolongation of the T1-25 period or of the maximal EMG depression could be observed, while after 400 mg cimetidine there was significant prolongation (mean 161 +/- 14.8%) of the T1-25 period and significantly greater EMG depression compared with the pre-cimetidine values. In the groups with 200 mg cimetidine or 100 mg ranitidine few patients showed prolongation of the T1-25 period up to 130%. DISCUSSION. Our results confirm experimental studies that have shown cimetidine to enhance aminoglycoside--relaxant interactions. Because we found an immediate response to the administration of the H2 antagonists, the interaction cannot be on the elimination side; it must be at the neuromuscular junction. Experimental investigation has shown that calcium reverses the cimetidine effects. It is therefore probable that the cimetidine--relaxant interaction occurs at the presynaptic level. Careful observation seems to be necessary if H2 antagonists, especially cimetidine, are administered intraoperatively at the same time as drugs that also enhance
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PMID:[Interactions of H2 antagonists and non-depolarizing muscle relaxants]. 256 80

Spinal anaesthesia with 3 ml, 4 ml or 5 ml of plain 0.5% bupivacaine was performed in three groups of 20 orthopaedic (ASA 1) patients at the LIV-V interspace. Patients aged less than 20 years or more than 60 years and those outside the normal range of body mass index were excluded. The spread of analgesia was greater in the 4-ml and 5-ml groups compared to the 3-ml group at each testing time (P less than 0.05). The mean maximum cephalad spread of pinprick analgesia (+/- s.d.) 60 min after injection was significantly higher (P less than 0.05) in the 4-ml group (T10 +/- 3.2) and in the 5-ml group (T10 +/- 2.7) than in the 3-ml group (T12 +/- 2.1). The interindividual variability of the cephalad spread of analgesia was greater in the 4-ml and 5-ml groups compared to the 3-ml group (P less than 0.05). The degree of motor block was higher in the 5-ml group than in the 3- and 4-ml groups at 5 and 15 min after injection. In seven patients the first sign of motor block was the patient's inability to flex the ankle, rather than inability to raise an extended leg as was the case in the other patients. In all patients satisfactory anaesthesia for surgery of the lower extremity was achieved.
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PMID:Spread of spinal anaesthesia using various doses of plain 0.5% bupivacaine injected at the LIV-V interspace. 258 97

Forty-three ASA physical status I-II adult patients, receiving spinal anesthesia for lower abdominal or lower limb surgery, were allocated randomly to two groups. Group 1 patients (n = 21) were given heavy bupivacaine 12 mg and group 2 patients (n = 22) were given tetracaine 12 mg in 2.5 mL of 10% dextrose. Spinal anesthesia was performed in the lateral decubitus position the at L 3-4 interspace with a 25-G spinal needle. Radial artery blood samples were collected before and after spinal anesthesia fpr pH measurement using a NOVA Biomedical machine; CSF samples were collected before and after injection of local anesthetic, and local anesthetic was also collected at the same time, for pH measurement using a Radio pH meter. The time from injection to maximal cephalad spread of analgesia and level of spinal analgesia were measured by the pin-prick method. The result was regarded as a failure if pain sensation still existed at the level of the operation site after spinal anesthesia. There were 1 failure case in the bupivacaine group and 2 failures in tetracaine group. The pH of CSF and local anesthetic in these failures were compared with those in effective cases, and the results showed that there was no significant relationship between the pH value of CSF and the local anesthetic drug.
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PMID:Effects of pH of cerebrospinal fluid and local anesthetic on the success rate of spinal anesthesia. 263 18

The potential clinical utility of drug interactions between morphine and the cholecystokinin antagonist proglumide was examined in 80 postoperative patients suffering from moderate to severe pain. Four groups of ASA I-III patients (mean age 51 years, mean weight 72 kg) recovering from major abdominal or gynecological surgery (mean duration of surgery 141 minutes) performed under balanced anesthesia (midazolam, droperidol, fentanyl, N2O, enflurane) were randomly assigned to self-administer morphine-proglumide mixtures on the first postoperative day (ODAC; morphine demand dose 3 mg; infusion rate 0.36 mg/hr; lockout time 2 minutes; hourly maximum dose 15 mg/hr; proglumide doses per demand 0, 50 micrograms, 100 micrograms, or 50 mg). Morphine consumption, actual as well as retrospective pain scores (0-5) and side effects were evaluated. Mean duration of patient-controlled analgesia (PCA) in the subgroups was 17-19 hours, during which time 24.6 +/- 9.5 to 28.0 +/- 3.4 micrograms morphine.kg-1.hr-1 was given. There were no statistically significant differences between the groups either for drug consumption, pain scores, or side effects. It is therefore concluded that proglumide does not potentiate morphine analgesia in a clinical (postoperative) setting.
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PMID:Failure of proglumide, a cholecystokinin antagonist, to potentiate clinical morphine analgesia. A randomized double-blind postoperative study using patient-controlled analgesia (PCA). 264 68

The side-effects of two opioid agonist-antagonists, nalbuphine and pentazocine, were assessed when used for patient-controlled postoperative analgesia. Forty ASA I or II patients scheduled for upper abdominal surgery were randomly allocated to two equal groups. The anaesthetic technique was the same for all the patients: premedication with atropine and diazepam, induction with thiopentone and suxamethonium and maintenance with fentanyl, pancuronium, nitrous oxide and halothane. Patient-controlled computer assisted analgesia (On-Demand Analgesia Computer) was started in the recovery room at least 2 h after the last administration of fentanyl. The parameters used were: a routine hourly dose (the half of that received during the previous hour), with on demand delivery of nalbuphine (15 micrograms.kg-1) or pentazocine (45 micrograms.kg-1) aliquots respectively, with a refractory period between two demands of 4 min and a total hourly maximum dose of 16 mg and 48 mg respectively. The following parameters were measured before the start of self-administration, and every hour afterwards for 24 h: systolic (Pasys) and diastolic blood pressures, heart rate, pressure-rate product (PRP), respiratory rate, end-tidal CO2 and pain (by way of a three point scale). Analgesia was assessed on a four-point scale every 6 h. The total doses of nalbuphine and pentazocine administered were 94 +/- 43 mg and 251 +/- 150 mg respectively. The only parameters significantly different between the two groups were Pasys and PRP, being higher in the pentazocine group. There were no significant differences in the side-effects (drowsiness, nausea, vomiting, headache, amnesia, logorrhoea and urine retention). All patients in both groups were satisfied with this technique.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Comparison of nalbuphine and pentazocine in the treatment of postoperative pain by self-administration]. 266 Jun 40

A lack of uniform methodology used in the assessment of different injection speeds in spinal anesthesia by different authors formed the basis of the current study, which compared under randomized conditions the effects of various injection speeds during intrathecal administration of 4 ml 0.5% hyperbaric bupivacaine or 0.5% hyperbaric tetracaine. MATERIALS AND METHODS. Eighty male ASA Physical Status II and III patients scheduled for transurethral resection of the prostate under spinal anesthesia were selected. They were randomly divided into four groups of 20 each. Patients were given 4 ml of either 0.5% hyperbaric bupivacaine or 0.5% hyperbaric tetracaine according to the following scheme: I: 4 ml tetracaine/0.25 ml.s-1; II: 4 ml tetracaine/0.5 ml.s-1: III: 4 ml bupivacaine/0.25 ml.s-1; IV: 4 ml bupivacaine/0.5 ml.s-1. The study was carried out in a double-blind fashion and puncture was performed at the L3-4 interspace using a 25-gauge needle with the patient in the sitting position. Following injection of the anesthetic solution (0.25 ml.s-1 or 0.5 ml.s-1 without barbotage), the patient was immediately placed in the lithotomy position with the table remaining horizontal. The level of anesthesia using pin prick and the degree of motor blockade, using a 0 to 3+ scale where 0 represented no motor weakness and 3+ complete motor block, were assessed at specific intervals. Statistical analysis was performed using the Mann-Whitney rank sum test: P value of less than 0.05 was considered statistically significant. RESULTS. Bupivacaine injected at 0.25 ml.s-1 was associated with a higher dermatome level than at 0.5 ml.s-1 (P less than 0.05). Time to highest dermatome, however, was shorter with bupivacaine 0.5 ml.s-1 compared to 0.25 ml.s-1 (P less than 0.05) (Table 3, Fig. 1). Time to highest level of analgesia was shorter with tetracaine 0.25 ml.s-1 compared to 0.5 ml.s-1 (P less than 0.05) (Fig. 2). At 0.25 ml.s-1, tetracaine achieved the highest dermatome faster than bupivacaine (P less than 0.05). Tetracaine injected at 0.5 ml.s-1, however, was associated with a higher segmental level than bupivacaine (P less than 0.05). At 0.25 ml.s-1 bupivacaine and tetracaine achieved a 3+ motor block faster than at 0.5 ml.s-1 (P less than 0.05). Complete motor blockade, however, was significantly longer with tetracaine at both injection speeds (0.25 and 0.5 ml.s-1) compared to bupivacaine (P less than 0.05). CONCLUSIONS. The results suggest that 4 ml 0.5% hyperbaric bupivacaine or tetracaine injected at 0.25 or 0.5 ml.s-1 provides a rapid and reproducible spread of analgesia for transurethral surgery. However, our findings suggest that speed of injection is of little i
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PMID:[The effect of the injection speed on the blockade characteristics of hyperbaric bupivacaine and tetracaine in spinal anesthesia]. 267 28

60 patients (ASA class I-II) undergoing knee arthrotomy received in a double blind fashion, a transdermal drug delivery system, containing either fentanyl (delivery rate of 75 micrograms/hour)--Fentanyl TTS--or placebo. The system remained in place for 24 hours. Even when piritramid was added as escape analgesia, all respiratory and hemodynamic parameters, as well as blood gas analysis showed no statistical significant difference between both groups (fentanyl or placebo). One patient had evidence of a beginning respiratory depression, but no specific therapy was needed. No significant side effects were seen. Concerning escape medication, a highly statistically significant difference in favour of Fentanyl TTS was found (p less than 0.001).
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PMID:Transdermal fentanyl against postoperative pain. 267 77

Addition of fentanyl to bupivacaine administered for spinal anesthesia for cesarean delivery was evaluated in 56 ASA physical status 1 term parturients. Preservative-free saline was added to 0, 2.5, 5, 6.25, 12.5, 25, 37.5, or 50 micrograms fentanyl to make a 1 ml total volume, which was injected intrathecally prior to bupivacaine in a double-blind, randomized fashion. Vital signs, sensory level, motor block, pain score, and side effects were recorded every 2 min for the first 12 min and then at 15, 30, 45, and 60 min and at 30-min intervals until the patient complained of pain. At delivery maternal vein, umbilical artery, and umbilical vein blood gases were obtained. Apgar scores at 1 and 5 min were recorded. Early Neonatal Neurobehavioral Scales (ENNS) were performed on days 1 and 2. Side effects and opioid requirements were recorded for the first 24 h. All of the patients in the control group reported a pain score greater than 0 during surgery and 67% required intraoperative opioids. None of the patients who received greater than or equal to 6.25 micrograms fentanyl required intraoperative opioids. Complete analgesia (time from injection to first report of pain) lasted 33.7 +/- 30.8 min (mean +/- SD) in the control group and increased to 130 +/- 30 min (P less than 0.05) with addition of 6.25 micrograms fentanyl. Duration of effective analgesia (time from injection to first parenteral opioid) was 71.8 +/- 43.2 min in the control group and increased (P less than 0.05) to 192 +/- 74.9 min with addition of 6.25 micrograms fentanyl.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Perioperative analgesia with subarachnoid fentanyl-bupivacaine for cesarean delivery. 267 37

The analgesic effect of extradural clonidine was evaluated in a double-blind study. In the recovery room, following orthopaedic or perineal surgery 20 ASA I and II patients were allocated randomly to two groups. The extradural clonidine (EC) group received clonidine 2 micrograms kg-1 in isotonic saline solution 15 micrograms ml-1. The extradural saline (ES) group received the equivalent volume of plain isotonic saline solution. Pain was evaluated by a visual analogue scale (VAS) at 15-min intervals for the first 2 h and subsequently at 30-min intervals for the following 4 h. Morphine 5 mg was given s.c. when patients complained of pain after extradural saline or clonidine. In the EC group, the mean (SD) maximum pain relief was 68.2 (24.1)% of the initial VAS score, but it was only 14.7 (25.2)% in the ES group. The mean duration of analgesia, before injection of morphine, was significantly longer in the EC group (210 (87) min) compared with the ES group (45 (27) min) (P less than 0.001). Drowsiness and moderate hypotension were observed in the EC group.
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PMID:Postoperative analgesia with extradural clonidine. 268 51

After standard preparation, the catheter is preferably inserted in a sitting position. A test dose of 4 ml etidocaine 1% is injected, initially followed by 1 ml per segment of the total calculated analgesic dose. Analgesic spread, blood pressure, and pulse are checked every 2 min. If a sufficient effect is not reached within 20 min, a further 2 ml per segment is injected. The patient is sedated in the operating room with diazepam, droperidol, or chlorpromazine and receives 6-8 l O2 during spontaneous respiration via a Hudson mask. The epidural catheter is left in place for postoperative analgesia. Intubation is used only as required. Of a total of 52 patients, 31 (60%) did not require intubation, 24 (46%) were age 70 or older, and 31 (60%) were classified as ASA risk group III-IV. Thirty-three of all the procedures (63%) involved upper abdominal surgery (liver, gallbladder) and the majority of these received thoracic (Th 9-10) punctures, with the catheter inserted 5 cm in the epidural space; 88% were punctured medially and 12% laterally. The most frequent complications were bradycardia and hypotension. Respiratory arrest and aspiration were not seen. Thoracic epidural catheter anesthesia can be carried out with or without intubation and with a minimum of complications in selected procedures. Postoperative analgesia is an important advantage.
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PMID:[Endotracheal intubation in thoracic catheter peridural anesthesia]. 277 75


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