Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The capability of reflex points on the external ear to alter neuromuscular and neuropathic disorders has been attributed to the descending pain inhibitory pathways of the central nervous system. The inverted fetus perspective of the somatotopic arrangement of auricular acupuncture points was first described in the 1950's by Dr. Paul Nogier of France, and has received scientific support from double blind studies examining auricular diagnosis of musculoskeletal and of coronary disorders. Acupuncture points on the ear and on the body have lower levels of electrical skin resistance than surrounding tissue. These electrodermal differences are apparently related to autonomic control of blood vessels rather than increased sweat gland activity. The heightened tenderness of reactive acupuncture points may be explained by the accumulation of noxious, subdermal substances. Electrical stimulation of specific points on the external ear leads to site specific neural responses in different regions of the brain. Behavioral analgesia produced by auricular acupuncture can be blocked by the opiate antagonist naloxone, indicating the role of endorphinergic systems in understanding the underlying mechanisms of auriculotherapy. The anatomical structures and electrical application of the auricle are described as they relate to the localization of master points, musculoskeletal points, internal organ points, and neuroendocrine points.
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PMID:Auriculotherapy stimulation for neuro-rehabilitation. 1201 47

A 15-year-old Pony of America (POA) gelding presented for evaluation of a large mass present on the right external pinna. Based on gross appearance, the right ear mass was suspected to be neoplastic. The most likely differential diagnosis was that of a fibroblastic sarcoid. Complete auriculectomy via use of a constricting latex-tourniquet performed under multimodal analgesia was proposed as an option to achieve complete resolution of mass growth and improve patient comfort. Benefits of latex tourniquet constriction included immediate lack of bleeding associated with amputation, gradual ischemic necrosis and sloughing of tissue distant to the site of constriction, and cost-effective application. The external pinna sloughed 3 weeks following application of the constricting latex tourniquet. Complete healing was achieved within 3 months from the time of tourniquet application. The middle ear canal sealed closed as a result of auriculectomy, with no observed long-term discomfort or morbidity aside from reduction in hearing. This is the first report of total external ear amputation in the horse. Complete auriculectomy via use of a constricting latex tourniquet is a feasible method for en-bloc removal of large, complicated ear masses.
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PMID:En-bloc Auriculectomy for Removal of a Large Pinna-Based Ear Mass in a Horse. 3319 36