Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The leaves of the plant "Cardospermum helicacabum" were extracted with different solvents and found to contain largely tannins, saponins and traces of alkaloids. The alcoholic extract was tested for its pharmacological effects on various intact and isolated biological preparations. On the CNS the extract produced depression in near lethal doses. On the CVS the extract produced fall of blood pressure and bradycardia. The fall of blood pressure was antagonised partially by atropine and anti-histamine. On guinea pig ileum the extract produced powerful contraction which was partially antagonised by atropine and anti-histamine. The extract produced mild analgesia as tested by the radiant heat method in rats. It appears to be a proconvulsant in nature as tested by the electroshock method in rats. The extract when administered orally produced significant anti-inflammatory effect in rats as tested by the granuloma pouch and cotton pellet implantation methods.
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PMID:Studies on the pharmacological actions of Cardiospermum helicacabum. 101 Jun 35

Cyclic vomiting syndrome (CVS) is a chronic, recurrent disorder of unknown etiology characterized by episodes of nausea and vomiting lasting hours or days and separated by symptom-free intervals of weeks to months. Although several different therapeutic regimens have been suggested for CVS, there remains no standard, effective regimen. In many cases, management of vomiting episodes includes the use of potent sedatives that induce prolonged durations of sedation and sleep. Dexmedetomidine is an alpha(2) adrenergic agonist with an increased specificity for the alpha(2) versus the alpha(1) receptor when compared with clonidine. Several physiologic effects have been demonstrated with dexmedetomidine including sedation, anxiolysis, analgesia, and blunting of the sympathetic nervous system. We report, for the first time, successful use of dexmedetomidine to treat CVS in 3 pediatric-aged patients. Potential mechanisms for its efficacy and future potential as a therapeutic agent for CVS are discussed.
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PMID:Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome. 1284 96