Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Oesophagogastrectomy is the best available treatment for patients with carcinoma of the oesophagus or cardia. It provides better longevity than other types of therapy and remains the standard against which combined modality treatment should be compared. Our experience with two hundred and twenty-four patients who underwent surgical exploration performed transdiaphragmatically by way of a left thoracotomy formed the basis of this report. Of these 224 patients, 201 (89.7%) underwent resection, 15 were bypassed and the remaining 5 patients were intubated. Of those resected, 79 patients required a two-rib thoracotomy. The postoperative mortality rate was 3.57%, and morbidity, mainly caused by respiratory complications occurred in 36 patients (16.1%), with no patients requiring ventilatory support. Surgical bypass without resection carried a higher mortality rate (8.3%) than those for resection (2.5%). All anastomosis were hand sewn. There were no anastomotic leaks. Adequate analgesia was provided by continuous extrapleural intercostal nerve block. Five year survival for squamous carcinoma was 36% while that adenocarcinoma was 18.7%. The left thoracotomy provides an effective method for undertaking oesophageal resections with low mortality and morbidity rates. This techniques has advantages and should be more widely used in the surgical management of patients with carcinoma of the oesophagus or cardia.
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PMID:Left thoracotomy approach for resection of carcinoma of the oesophagus and cardia. 160 42

Oesophagogastrectomy is the best available treatment for patients with carcinoma of the oesophagus or cardia. A retrospective analysis of our experience with 485 patients who were treated surgically forms the basis of this report. Of the 317 patients who underwent resection (resectability rate of 65%) only 210 were considered to be potentially curative. Overall, the 5-year survival rate for oesophageal cancer was 3%, whilst curative resection had a 5-year survival rate of 22% and varied according to stages. Five-year survival rate was 67.7% for patients with Stage I disease compared with 27.6, 9.4 and 6.4% for Stages IIa, IIb and III disease respectively. There were no 5-year survivors with Stage IV disease or with those patients who underwent an incomplete resection. Curative resection carried a mortality rate of 3.8%, whereas incomplete resection or palliative procedure carried higher mortality rates of 14 and 20.7% respectively. Adequate post-operative analgesia was provided by continuous extrapleural intercostal nerve block. Morbidity, mainly caused by respiratory complications, occurred in 30 patients (6.2%), with three patients requiring ventilatory support. Outcome was influenced mostly by the extent of the disease and the completeness of surgical resection rather than by histological type. We conclude that surgical treatment provides better longevity than any other type of therapy and remains the standard against which combined modality treatment should be compared. Our experience suggests that surgical treatment can be achieved with minimal morbidity and mortality.
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PMID:Results of surgical treatment of oesophageal cancer. 890 51