Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intraoperative analgesia was performed using a combination of tramal at a dose of 2-2.5 mg/kg and transcranial electrical stimulation under halothane-nitrous oxide-oxygen mask anesthesia. The study was performed in 12 apparently healthy boys aged 11-13 operated on for II to III degree varicocele. The efficacy of postoperative analgesia was assessed in 68 children aged 8 to 14 subjected to surgery for inguinal and umbilical hernia, varicocele, cryptorchidism. Parameters of central hemodynamics and cardiopolygraphy have been assessed. Intraoperative use of tramal was accompanied by a prompt recovery of the balance between sympathetic and parasympathetic impacts on the heart and stability of central hemodynamic parameters. Postoperative analgesia with tramal is an effective technique enabling a prompt recovery of pain-induced disturbances in the relations between sympathetic and parasympathetic compartments of the autonomic nervous system. Among the adverse events one can name nausea (25%), repeated vomiting (12%) and allergic reactions (1.4%).
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PMID:[Use of tramal during minor surgical interventions in children]. 794 99

The purpose of the case-study was to evaluate the efficiency of non-steroid antiinflammatory drugs (NAD) for postoperative analgesia in children after small-scope surgical interventions. Diclofenac, 1 mg/kg per day administered as rectal suppositories or intramuscular injections after initial narcosis, was used for postoperative analgesia in children of the main group; postoperative analgesia made by analgin and promedol in the control group was compared with the former. Forty-seven children and 10 children with identical diseases like groin hernia, varicocele and dropsy of testicular membranes, were respectively in the main and control groups. Clinical examinations and registration of functional parameters were made in patients during certain time periods, i.e. before surgery (in the standing and lying postures) and after surgery (in 20 minutes, as well as in 1, 2, and 3 hours after surgical interventions). The efficiency of postoperative analgesia was evaluated by means of cardiointervalography according to Bayevsky method as well as by a state of central hemodynamics and by clinical examinations, including the visual-analogue 10-point scale and the 0-4 point verbal pain assessment scale. The postoperatively obtained data revealed a pronounced misbalance between the main and control groups, which is indicative of that the application of NAD for preventive and postoperative analgesia in children improves essentially the postoperative course and contributes to a fast rehabilitation of patients. A comparative analysis of the efficiency of postoperative analgesia by the discussed drugs showed that diclofenac possesses a sufficient analgetic activity and is free of any side-effects inherent in narcotic analgetics.
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PMID:[Postoperative analgesia with nonsteroid anti-inflammatory drugs in children]. 1520 15

Acupunctural reflexotherapy has been performed in patients during minimally invasive treatments for benign prostatic hyperplasia and in patients with lower urinary tract symptoms. We report two cases of left internal spermatic vein ligature for varicocele and a case of circumcision using acupunctural reflexotherapy, a procedure, to our knowledge, never applied before in open surgery. A 38 and a 24 years old male patients came to our observation for a 2nd degree symptomatic left varicocele and a 40 years old patient came to have a circumcision; they requested alternative anaesthesia for the operation and acupunctural reflexotherapy has been performed. This technique for analgesia can be useful and can be applied in selected cases, i.e. minor surgery in patients who do not wish or cannot have a general anaesthesia; it can be associated to other techniques of anaesthesia as peri- and post-operative analgesia. No contraindications nor collateral effects exist. The limits of this methods are represented by the length of time required for preparation of the patient and the existence of patients non-responder to electrostimulation.
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PMID:Acupunctural reflexotherapy as anaesthesia in day-surgery cases. Our experience in left internal vein ligature for symptomatic varicocele and in circumcision. 1569 33

The purpose of the present study was to comparatively assess the adequacy of postoperative analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol in children undergone "minor" surgical interventions. For postoperative analgesia in children, the authors used paracetamol in a single dose of 25-30 mg/kg, diclofenac in a dose of 1.5-2.0 mg/kg, which were rectally administered as suppositories, as well as diclofenac in the same dose as intramuscular injections (Group 1). A comparison was made with postoperative analgesia using analgin and promedole (Group 2 (control)). Group 1 comprised 63 patients and Group 2 included 26 patients with identical diseases (inguinal hernias, varicocele, phimosis). Functional parameters were recorded in patients in the lying position before, 30 min, 1, 2, and 3 hours after surgery. The efficiency of postoperative analgesia was evaluated, by using central hemodynamic parameters that many investigators consider to be one of the major criteria for the adequacy of anesthesia. Comparison of postoperative data has revealed a difference between the groups, which suggests that the use of NSAIDs and paracetamol for preventive and postoperative analgesia in children substantially improves the postoperative period and promotes a rapid rehabilitation in patients. Comparative analysis of the efficiency of postoperative analgesia of the above agents has indicated that diclofenac and paracetamol have a sufficient analgesic activity and at the same time do not show the adverse reactions unique to narcotic analgesics.
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PMID:[Effect of nonsteroidal anti-inflammatory drugs and paracetamol on hemodynamic changes during postoperative analgesia in children]. 1583 18

Forty-one children aged 4 to 15 years, who had been operated on for varicocele and hernias at various sites, were examined. Central hemodynamics, and the level of sedation and pain were assessed. Studies were performed in 2 groups of patients: 1) those who received anesthesia with ketamine in combination with propofol and 2) those who had inhalational-mask anesthesia using phtorotan in combination with nitrous oxide. They indicated that the patients more promptly emerged from phtorotan anesthesia; however, they require preventive analgesia.
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PMID:[The early postanesthetic period in children]. 1661 41

To assess the efficacy of transversus abdominis plane (TAP) block as anesthesia method for retroperitoneal varicocele repair and to evaluate its postoperative analgesic effectiveness. Thirty-three consecutive male patients undergoing retroperitoneal varicocele repair (Palomo technique) were enrolled in this study. Patients were randomly allocated to undergo ultrasound-guided TAP block anesthesia (case group), or conventional spinal anesthesia (control group). The primary outcome was the evaluation of the proportion of patients achieving an adequate anaesthesia (as evaluated by prinprick sensation test and by the need of analgosedation). We have also evaluated pain during the intervention and pain on movement, pain at rest, rescue analgesia need, nausea, and satisfaction at different time-points (6, 12, and 24 h after surgery). The proportion of patients achieving adequate anesthesia was not different between the groups (p = 0.1). In the post-operative evaluation, patients enrolled in the case group expressed significantly less pain on VAS score at rest and on movement at 6 (p = 0.001 and p = 0.001) and at 12 h (p = 0.004 and p = 0.01). Moreover, the need of rescue analgesia resulted significantly higher in the control group (p = 0.03). This is the first study showing that TAP block could be employed as an effective and feasible anesthesia method for the retroperitoneal varicocelectomy. Moreover, our results demonstrate that this method is more effective than spinal anesthesia in the pain control after varicocele repair.
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PMID:Ultrasound-guided transversus abdominis plane block for retroperitoneal varicocele repair. Could it be an anesthesia method? 2361 29