Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The distribution of binding sites of [125I]RTI-55 (3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester), a phenyl tropane analog of cocaine, and the selective labeling of the dopamine transporter (DAT) were studied by in vitro and ex vivo autoradiography in the rat whole brain. Recent evidence has shown that RTI-55 binds to not only DAT but also serotonin transporter (5HTT). In the present study, in vitro autoradiography revealed that [125I]RTI-55 bound to the olfactory tubercle, the caudate putamen, the accumbens nucleus, the midline and lateral geniculate nuclei of the thalamus, the hypothalamic nuclei, the substantia nigra compact part, the subthalamic nucleus, the ventral tegmental area, the superior colliculus, the dorsal raphe nucleus, and the facial nucleus. Further, in the presence of clomipramine, a selective ligand for 5HTT, [125I]RTI-55 binding was remarkably inhibited in the midline and lateral geniculate nuclei of the thalamus, the hypothalamic nuclei, the superior colliculus, the dorsal raphe nucleus, and the facial nucleus, while [125I]RTI-55 binding remained in the olfactory tubercle, the caudate putamen, the accumbens nucleus, the substantia nigra compact part, the subthalamic nucleus, and the ventral tegmental area. These findings suggest that [125I]RTI-55 binds to 5HTT in the former areas and to DAT in the latter areas. It is therefore concluded that RTI-55 is a suitable ligand for studying the action of cocaine in whole brain regions, including the thalamus, the hypothalamus and the dorsal raphe nucleus, regions in which cocaine is thought to act evoking several neurological effects, e.g., analgesia and elevation of adrenocorticotropic hormone. DAT was also labelled selectively both in vitro and in vivo using [125I]RTI-55 combined with clomipramine. Therefore, radiolabelled RTI-55, combined with unlabelled clomipramine, which displaces its binding to 5HTT, also appears to be suitable for the selective imaging of DAT in vivo.
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PMID:Distribution of cocaine recognition sites in rat brain: in vitro and ex vivo autoradiography with [125I]RTI-55. 780 67

The authors present a program of rational improvement of intensive therapy of acute respiratory insufficiency responsible for the development of normal compensatory processes of external ventilation. The main components of intensive therapy are: rational analgesia (continuous subpleural blockades), elimination of obstruction of respiratory pathways by sessions of independent respiration with oxygen mixture with positive pressure at the end of breathing out with phytoncides, moderate hemodilution, early recovery of enteral coming of fluid, prevention and treatment of respiratory infection. The use of the proposed intensive therapy in 41 patients improved the function of external ventilation and made the amount of pulmonary complications 4 times less.
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PMID:[The intensive therapy of acute respiratory failure in severe combined trauma with a closed chest injury]. 797 37

A young female whose pyridostigmine treatment had recently been changed presented with myasthenia gravis, acute respiratory failure, and respiratory infection. She was supported with a noninvasive negative pressure cuirass device as an aid to optimizing medical therapies without the confounding factor of pharmacology-induced sedation and analgesia.
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PMID:Respiratory failure in myasthenia gravis and negative pressure support. 980 42

We report an 8-year-old boy with Mycoplasma pneumoniae respiratory infection complicated by pneumomediastinum and severe oral and conjunctival mucositis. M. pneumoniae-associated mucositis is distinct from the Stevens-Johnson syndrome. There are no skin lesions and it improves promptly with antibiotics. Spontaneous pneumomediastinum usually only requires rest, analgesia and management of the underlying condition.
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PMID:Mycoplasma pneumoniae infection complicated by pneumomediastinum and severe mucositis. 1748 33