Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cowden syndrome is a rare syndrome of chromosome abnormalities presenting with polyposis of digestive tracts, characteristic skin eruption and neuromuscular disorders. A 56-year-old male patient with Cowden syndrome underwent upper abdominal surgery under general anesthesia followed by post-operative epidural analgesia with buprenorphine. Proposed total gastrectomy was not performed because of massive invasion of carcinoma in the abdominal cavity and gastrojejunostomy was done instead. The anesthesia was satisfactory with inhalation of nitrous oxide and enflurane with intravenous vecuronium. Neuromuscular monitoring with electric twitch-responses of the hand showed normal patterns throughout the anesthesia. The recovery from anesthesia and neuromuscular blockade was prompt. Intermittent epidural buprenorphine, twice a day (0.2 mg of buprenorphine in 9 ml of normal saline for one time) was started just after the recovery of anesthesia and continued for four days. Delirium occurred two days after beginning epidural buprenorphine and disappeared three days after its discontinuation. The patient died 52 days after the operation from obstructive jaundice and sepsis. The delirium, therefore, seems to have been caused by buprenorphine possibly due to its impaired metabolism by the liver. Although we did not experience any abnormal neuromuscular reactions to vecuronium or anesthetic agents, it is important to perform preoperative neuromuscular examinations and peri-operative monitoring in the anesthetic management of a patient with this syndrome.
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PMID:[Anesthetic management of a patient with Cowden syndrome]. 773 7

Laparoscopic cholecystectomy for the treatment of gallstone disease has the advantages of a shorter postoperative stay, more rapid overall recovery time, and better cosmesis compared to open cholecystectomy. To assess the state of development of laparoscopic cholecystectomy in Brunei, a prospective review of all 220 such procedures performed at the RIPAS Hospital in Bandar Seri Begawan in 1992-96 was conducted. These cases represent the total number of procedures performed in Brunei to date. The standard four-portal technique was used with an open Hasson trocar placed at the umbilicus. 81 patients (37%) were male and 139 (63%) were female; the mean age of patients was 46 years. Indications for the procedure included biliary colic (130 cases), acute cholecystitis (47 cases), and obstructive jaundice caused by gallstones (26). The mean operating time was 109 minutes. 9 patients (4%) required conversion to open surgery. The overall morbidity rate was 5%, with one ductal injury (0.5%). Gallbladder perforation with leakage of bile and/or gallstones occurred in 17% of cases. There was 1 death in this series (0.5% mortality), involving an 87-year-old woman with postoperative bronchopneumonia. 57% of patients did not require any form of analgesia in the postoperative period. The mean hospital stay was 3 days.
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PMID:A prospective review of laparoscopic cholecystectomy in Brunei. 956 65

This study evaluates the incidence of biliary leakage following T-tube removal from the common bile duct (CBD) in 97 patients who underwent open CBD exploration. In 93 patients, this was following exploration for CBD stones, in two patient it was for obstructive jaundice due to hydatid disease and in a further two patients it was following CBD injury. T-tube cholangiography (TTC) was carried out 7-10 days postoperatively and, if the examination was normal, the T-tube was removed 12-14 days postoperatively (2 months for the CBD injury patients). Following T-tube removal, six patients developed severe abdominal pain, sweating and tachycardia. They were treated with antibiotics, parenteral fluids, and analgesia. Three patients settled with this management. Two patients developed sub-hepatic collections and required open drainage. One patient developed a small pelvic collection, which was aspirated transvaginally. A seventh patient was re-admitted 2 weeks following T-tube removal and laparotomy revealed biliary peritonitis. The patient died the following day. Biliary leakage following removal of a T-tube is not uncommon. It has a significant morbidity and mortality. Our experience and that of the reviewed literature suggests that the aetiology is multifactorial. The management and outcome of this complication is discussed.
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PMID:Biliary leakage following T-tube removal. 1081 34