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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical recommendations for analgesics in laboratory rodents are usually derived from basic research. However, animal models of pain often involve withdrawal reflexes evoked by threshold-level stimuli, whereas pain associated with surgery or disease involves injury and inflammation. Moreover, the analgesics used in research tend to be chosen as exemplars of a drug class, without regard for whether the route of administration is practical, whether the drug has useful kinetics or whether the side effects are tolerable. This paper provides data on the efficacy of drugs from four classes, using the formalin test as a model of injury-induced pain. Formalin (50 microliters, 2.5 per cent) was injected subcutaneously into a rat's paw and the behavioural response (lifting or licking of the paw) was recorded. Buprenorphine at 0.1 mg/kg and dipyrone at 200 mg/kg completely suppressed the pain responses. When formalin was injected six hours after buprenorphine or dipyrone, pain scores were 30 per cent of control scores. In the absence of pain and handling, 0.6 mg/kg buprenorphine was lethal to 25 per cent of rats. Locomotor activity was slightly depressed by 300 mg/kg dipyrone. Xylazine at 2 mg/kg suppressed pain responses, but the analgesia had decreased to less than 50 per cent after two hours and the effects were variable thereafter; at 8 mg/kg rats were unresponsive to a strong pinch. Acepromazine at 2.5 mg/kg reduced pain to 20 per cent of control scores and this level of analgesia was maintained for six hours; neuroleptic effects were prominent at 5 mg/kg.
Vet Rec 1997 May 24
PMID:Options for management of acute pain in the rat. 918 12

Sixty cats which underwent an ovariohysterectomy were randomly allocated into four treatment groups. One group (controls) received no analgesics postoperatively, and the others received either a single dose of buprenorphine (0.006 mg/kg) intramuscularly, or pethidine (5 mg/kg) intramuscularly, or ketoprofen (2 mg/kg) subcutaneously. The analgesia obtained after each treatment was assessed by three measures. There were significant differences between the groups both for the requirement for intervention analgesia (P = 0.0008) and for the overall clinical assessment (P = 0.0003) with ketoprofen requiring least intervention analgesia and having the best overall clinical assessment, followed by buprenorphine then pethidine. The control group required the most intervention analgesia and had the worst overall clinical assessment. Visual analogue scale scoring for pain produced significant differences between the groups from one hour after the operation, with the cats which were given ketoprofen tending to have lower pain scores than the other groups.
Vet Rec 1998 Aug 15
PMID:Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat. 976 58

The effects of factors such as the position of the tongs, the presence of wool, and the wetness of the skin on the efficiency of the head-only stunning procedure, and the duration of the periods of unconsciousness and analgesia were studied in lambs. The degree of insensibility was determined from the evaluation of physiological responses and electroencephalograms. The proportion of successfully stunned animals was significantly higher (P<0.05) in the animals stunned with the tongs in a frontal position than in those stunned with them in a caudal position, in the animals stunned with wet electrodes than in those stunned with dry electrodes and also in the animals without wool than in those with wool. The interval between stunning and sensibility to pain was affected significantly (P<0.01) only by the position of the tongs, being longer in animals with them in a frontal position than in those with them in a caudal position.
Vet Rec 2000 Jul 08
PMID:Factors affecting the effectiveness of head-only electrical stunning in sheep. 1095 92

Thirty bitches undergoing routine neutering were used in an assessor-blinded trial of the postoperative analgesic effects of pethidine and carprofen administered either together or singly. The level of analgesia was assessed by visual analogue scale (VAS) scores for pain and sedation and by nociceptive mechanical threshold testing. The two drugs administered together, and carprofen alone, provided good postoperative analgesia as assessed by VAS scoring. Pethidine alone did not provide postoperative analgesia of sufficient duration.
Vet Rec 2001 Apr 07
PMID:Analgesic effects in dogs of carprofen and pethidine together compared with the effects of either drug alone. 1133 14

Two groups of six mares aged from eight to 18 years were anaesthetised by caudal epidural injections of ropivacaine (0.5 per cent, 0.1 mg/kg) or a combination of ripovacaine (0.08 mg/kg) and fentanyl (100 microg) in a randomised study. The onset of anaesthesia was significantly more rapid (P<0.001) and it lasted significantly longer (P<0.001) in the group anaesthetised with the combination of drugs. The surgical comfort scores of the group anaesthetised with the combination were higher than those of the group anaesthetised with ropivacaine alone (P<0.001), and the quality of intraoperative analgesia, as assessed by the surgeon, was significantly improved. There were no differences between the groups in their average scores for the levels of ataxia and sedation, in their behaviour, or in the incidence of side effects.
Vet Rec 2004 Mar 13
PMID:Comparison of ropivacaine with a combination of ropivacaine and fentanyl for the caudal epidural anaesthesia of mares. 1506 41

Twenty-four Holstein cattle scheduled for flank surgery in a standing position were randomly assigned to four groups of six. A 16 G, 120 mm Tuohy needle was inserted into the first interlumbar epidural space and its position was confirmed by the hanging drop technique. After air had been allowed to enter freely for approximately one minute, the epidural needle was slowly inserted 7 to 10 mm deeper to penetrate the epidural fat, and anaesthetic solution containing either 0.05 mg/kg bodyweight xylazine hydrochloride (xylazine), 0.025 mg/kg xylazine, 0.025 mg/kg xylazine and 0.1 mg/kg lidocaine hydrochloride (lidocaine), or 0.2 mg/kg lidocaine alone was administered. Signs of sedation were observed in the three groups treated with xylazine and the number of spinal segments involved in the area of analgesia when the anaesthetic contained xylazine was significantly greater than with 0.2 mg/kg lidocaine alone ( < 0.01). After the treatment with 0-025 mg/kg xylazine and 0.1 mg/kg lidocaine, flank surgery was performed successfully without additional line block or side effects.
Vet Rec
PMID:Comparison of xylazine, lidocaine and the two drugs combined for modified dorsolumbar epidural anaesthesia in cattle. 1565 47

Fifteen adult dogs underwent elective ovariectomy. They were premedicated with 0.5 mg/kg methadone and 0.05 mg/kg(-1) atropine administered intramuscularly, and anaesthesia was induced with propofol and maintained with intravenous infusions of remifentanil at 0.6 microg/kg/minute and propofol; the mean (sd) rate of infusion of propofol throughout the period of anaesthesia was 0.33 (0.03) mg/kg/minute. The dogs were ventilated continuously with oxygen while they were anaesthetised. Their haemodynamic parameters were clinically acceptable during the period of anaesthesia. Two dogs received additional atropine to correct bradycardias of less than 60 bpm and several dogs received additional boluses of remifentanil or propofol to maintain an adequate depth of anaesthesia, as determined by a clinical assessment. The mean (range) time to the return of spontaneous respiration after stopping the remifentanil infusion was 11.1 (6.0 to 17.0) minutes, and the mean (range) time to the dogs standing was 38.0 (20.0 to 80.0) minutes. The quality of recovery was good in 12 of the dogs, two showed mild excitation in the immediate postoperative period and the other dog required additional analgesia with methadone.
Vet Rec 2005 Jun 18
PMID:Clinical investigation of remifentanil and propofol for the total intravenous anaesthesia of dogs. 1596 4

Twenty-eight dogs were randomly allocated into two groups. They were premedicated with either 10 or 20 microg/kg buprenorphine and 0.05 mg/kg acepromazine administered intramuscularly, and then anaesthetised with intravenous thiopentone to effect and maintained with isoflurane in 100 per cent oxygen. The dogs underwent routine castration, and a second dose of 10 microg/kg buprenorphine was administered four hours after the first or 20 microg/kg six hours after the first dose. Levels of pain and sedation were scored on a visual analogue scale and in terms of the dogs' requirement for rescue analgesia, and mechanical nociceptive thresholds were measured at the hock and wound at premedication and one, two, three, four, five, six, seven, 10 and 21 to 22 hours later. Pain scores were low in both groups, with a trend for lower scores in the high dose group; administration of the second dose of buprenorphine further decreased the pain scores. Buprenorphine produced good preoperative sedation and the level of sedation decreased over time after surgery. Administration of the second high dose of buprenorphine did not increase the level of sedation. Both doses of buprenorphine prevented hyperalgesia at the wound and hock postoperatively. Three dogs given the low dose and one dog given the high dose required rescue analgesia with carprofen.
Vet Rec 2006 Nov 18
PMID:Effects of two doses of buprenorphine four or six hours apart on nociceptive thresholds, pain and sedation in dogs after castration. 1711 81

Six male buffalo calves aged from six to eight months and weighing 100 to 120 kg were used to evaluate the efficacy and safety of caudal epidural analgesia produced by doses of 37.5 mg (5 ml) and 75 mg (10 ml) ropivacaine (0.75 per cent). The study was completed in two phases. In phase 1, all the animals were used twice to evaluate the analgesic and clinical effects of two doses of ropivacaine. In phase 2, the animals were divided into two groups of three to evaluate the effects of two doses of ropivacaine on some haemodynamic and acid-base parameters. Signs of analgesia, as evidenced by a loss of response to pinprick stimulation, were recorded only at the tail, perineum and hindlimbs of the animals given 5 ml ropivacaine, but they extended from the tail to the thorax (T9) in the animals given 10 ml ropivacaine. The duration of analgesia was five to six hours in the animals given 5 ml ropivacaine and seven to eight hours in the animals given 10 ml ropivacaine. Animals of both groups became recumbent, but the score for ataxia was higher in the animals given 10 ml ropivacaine. The respiratory rate decreased significantly (P<0.05) below the baseline in the animals given 10 ml ropivacaine, but the rectal temperature, heart rate, mean arterial pressure, central venous pressure and acid-base and electrolyte parameters did not change significantly in either group.
Vet Rec 2007 Jun 02
PMID:Comparison of two doses of ropivacaine for lumbosacral epidural analgesia in buffalo calves (Bubalus bubalis). 1754 47

Twelve healthy two-month-old Landrace x Yorkshire pigs of both sexes were randomly assigned to receive either tiletamine and xylazine (zx) or zolazepam and xylazine followed 20 minutes later by yohimbine (zxy). The pigs' scores for immobilisation and analgesia, and their rectal temperature, heart rate, respiration rate, pO(2), pCO(2), alkaline phosphatase, aspartate aminotransferase, glucose and total plasma proteins were determined before and five, 25, 45, 65 and 85 minutes after the administration of the tiletamine/zolazepam and xylazine. The mean total scores for immobilisation and analgesia of the zxy pigs were significantly lower than those of the zx pigs after 85 minutes. The mean rectal temperatures of the zxy pigs were significantly lower than those of zx pigs after 25, 45 and 65 minutes. The mean respiratory rates of the zx pigs were significantly lower than those of zxy pigs after five minutes. The mean pCO(2) of the zxy pigs were significantly lower than those of zx pigs five minutes after the administration of yohimbine. The mean glucose concentration of the zxy pigs were significantly lower than those of zx pigs after 65 and 85 minutes. The mean concentration total protein of the zxy pigs were significantly lower than those of zx pigs throughout the period of anaesthesia. Both groups became laterally recumbent within three minutes. When recovering from anaesthesia, the pigs treated with yohimbine took significantly less time to achieve sternal recumbency (mean [sd] 52.2 [8.9] v 76.2 [20.6] minutes) and less time to be able to stand (mean [sd] 77.0 [9.8] v 98.7 [15.8] minutes), and walk (mean [sd] 81.3 [11.3] v 110.8 [18.6] minutes).
Vet Rec 2007 Nov 03
PMID:Antagonistic effects of yohimbine in pigs anaesthetised with tiletamine/zolazepam and xylazine. 1798 41


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