Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0344232 (
blurred vision
)
2,072
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Many classes of anticancer therapy, including chemotherapeutic agents, hormonal and molecular targeted treatments, can produce ocular toxicity. Novel agents that target different cellular pathways have been related to a wide spectrum of ophthalmologic toxicities that can range from mild to severe, and include conjunctivitis,
blurred vision
, keratitis and optic neuritis, among others. Special attention has been drawn to the inhibitors of the
MEK
signaling pathway, due to their sine qua non ocular toxicity, defined as
MEK
retinopathy and described as symmetrical bilateral disease that develops in a time-dependent and dose-dependent manner. In this review, we discuss ophthalmologic toxicities associated with molecular targeted therapies, with particular focus on
MEK
retinopathy, including its nomenclature, incidence, symptoms and management.
...
PMID:Ocular toxicities of MEK inhibitors and other targeted therapies. 2695 25
