Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344232 (blurred vision)
 2,072 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

THe fitting of patients presenting a deficient tear film with hydrogel contact lenses offers a challenge to the professional who must choose between materials having either a low or a high water content. Conflicting conclusions from previous studies concerning the better option led the authors to design a single-centre, double masked, clinical study. Twenty-six subjects deemed to have 'tear film deficiency' were fitted with a low water content hydrogel lens on one eye and a high water content one on the other eye. Each subject wore the lenses on a daily wear basis (about 10 hours a day) for 30 days. A detailed questionnaire about subjective considerations, such as comfort and ocular appearance, was completed by the subjects at the end of every day of contact lens wear. The data obtained from these questionnaires and those recorded at three follow-up visits led to the final conclusions. THe questionnaires showed no statistically significant difference between the two eyes in dryness sensation, redness, light sensitivity, blurred vision or overall comfort. During the follow-up visits, no observed sign showed a clinically significant difference between the two eyes. Accordingly, the authors conclude that the water content of hydrogel lens is not a key factor when fitting hydrogel lenses to patients with 'tear film deficiency'.
Cont Lens Anterior Eye 2000
PMID:The influence of water content of hydrogel contact lenses when fitting patients with 'tear film deficiency'. 1630 26

A case of a 59-year-old Spanish patient who presented with severe ocular pain, blurred vision, eyelid swelling and foreign body sensation in the right eye is reported. She was a regular gas permeable contact lens [corrected] wearer who initially claimed to maintain standard lens care. After exploration, conjunctival injection, dendritiform corneal ulcers and stromal edema were observed. She was initially treated for a possible viral keratitis due to herpes simplex virus using 3% topical acyclovir and 0.1% dexamethasone eye drops 5 times a day. The patient did not respond to this treatment and six weeks later, corneal scrapings were positive for Acanthamoeba genotype T11. She was then treated with chlorhexidine 0.02%, propamidine 0.1% and 1% cycloplegic eye drops hourly which resulted in a significant improvement. After a month, ocular pain decreased and the clinical signs of keratitis ameliorated observed as a diminution of the size of the ulcer and also in the extension and opacity of the corneal infiltrates. The patient has been following this treatment for 3 months and it is possible that she will have to carry on with it for a whole year. To the best of our knowledge, this is the first case of severe keratitis due to Acanthamoeba genotype T11 in Spain .
Cont Lens Anterior Eye 2011 Apr
PMID:Acanthamoeba keratitis due to genotype T11 in a rigid gas permeable contact lens wearer in Spain. 2113 Jun 79

Bullous keratopathy is a pathological corneal condition that arises due to irreversible oedema associated with endothelial cell loss or dysfunction. Symptoms may vary from mild (transient blurred vision and increased glare from epithelial oedema) to severe (an acute and significant loss of vision associated with frank endothelial decompensation, and pain due to ruptured epithelial bullae). Possible treatments to restore vision and minimise pain include topical hypertonic agents, bandage contact lenses, superficial anterior corneal surgical procedures or penetrating full thickness or endothelial keratoplasty. This case report describes a rare presentation of painless, bilateral, asymmetric bullous keratopathy with severe vision loss in an elderly male with non-insulin dependent diabetes mellitus.
Cont Lens Anterior Eye 2018 10
PMID:Painless bilateral bullous keratopathy. 2957 98