Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0344232 (
blurred vision
)
2,072
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There are several treatment options now available for patients with CMV retinitis, a sight-threatening viral infection of the eye, and the benefits and drawbacks of each are detailed. Vitrasert implants are the top choice, selected by nearly half of all people with CMV retinitis. The implants can cause
blurred vision
for up to four weeks, and retinal detachment is a potential side effect. Physicians also recommend systemic CMV treatment, generally IV ganciclovir, to accompany the implant.
Cidofovir
(
Vistide
), another IV therapy, is time-consuming to administer and has severe side effects. ISIS 2922, the experimental drug fomivirsen, is a promising treatment that is currently in advanced trials; it is injected directly into the eye. Oral ganciclovir therapy, used for mild retinitis cases, requires 12 pills a day, at a cost of $1,200 per month, and is generally less effective than other treatments. Concerns about developing drug resistance are expressed.
...
PMID:Saving sight. 1136 57
