Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344232 (blurred vision)
 2,072 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute posterior multifocal placoid pigment epithellopathy is a chorioretinal inflammatory disease occurring in young, healthy adults. The long-term visual prognosis and recurrence rate is uncertain. We reexamined 28 patients (53 affected eyes) with acute posterior multifocal placoid pigment epitheliopathy (mean follow-up, 8 years) to obtain details on the long-term functional visual outcome. The final visual acuities were 20/25 or better in 48 eyes (90.6%), 20/30 to 20/100 in four eyes (7.5%), and 20/200 in one eye (1.9%). Although the final visual acuity was good, 33 eyes (62.3%) were symptomatic with blurred vision, metamorphopsia, or scotomas. Thirty-six eyes (67.9%) had significant central visual field defects on follow-up examination. There were no recurrences after the initial month of symptoms. The chorioretinal scars did not enlarge with time. Acute posterior multifocal placoid pigment epitheliopathy has a good longterm prognosis for visual acuity, although most patients have residual symptoms and paracentral scotomas.
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PMID:Long-term visual function in acute posterior multifocal placoid pigment epitheliopathy. 204 67

A questionnaire about postoperative complaints was given to patients after surgery for retinal detachment. Their visual acuity and visual field problems were analyzed. Only one third of all the patients felt postoperative improvement. Blurred vision and metamorphopsia after operation were complained of in one third of all the patients. Blurred vision was apt to be complained of in patients with macular detachment before operation. About 77% of patients with blurred vision had a visual acuity of less than 0.5. Metamorphopsia was frequently complained of in patients treated with the segmental buckling procedure.
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PMID:Subjective and objective ocular disturbances in reattached retina after surgery for retinal detachment, with special reference to visual acuity and metamorphopsia. 682 11

Acute blurred vision is a usual clinical setting which could be related to many different etiologies. The ophthalmologist has to precise the symptomatology to differentiate long or short visual acuity loss, troubles of accommodation, metamorphopsia or central scotomas. Then a complete ophthalmologic examination will try to localise the causative lesion in the cornea, the lens, the chorio-retina or in the intraocular media.
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PMID:[Acute blurred vision]. 774 50

We examined cone and rod electroretinograms to ganzfeld stimuli in a patient with crystalline retinopathy. The 54-year-old man complained of night blindness, blurred vision, and metamorphopsia in both eyes. His visual acuity was 10/200 in the right eye and 10/20 in the left eye; his subjective dark-adaptation threshold was elevated 1 log unit, and he made one tritan error on the Farnsworth Panel D-15. Specular microscopic examinations revealed tiny crystalline deposits in the limbal cornea bilaterally. Ophthalmoscopically, crystalline deposits were found in the posterior fundi. His light-adapted cone electroretinograms to white stimuli were diminished (about 30% of those of normal controls), with normal implicit times. His dark-adapted rod electroretinogram amplitudes were 10% of those of normal controls. The S-cone electroretinogram was not detectable to different spectral stimuli with strong white background, while the L-M-cone responses appeared normal in waveforms with reduced amplitude. These ERG results indicated that the patient's S-cone system is more highly impaired than the L-M-cone system, supporting the psychophysical evidence that the S-cone system is more vulnerable than other cone systems in retinal diseases.
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PMID:Nondetectable S-cone electroretinogram in a patient with crystalline retinopathy. 884 31

Cat-scratch disease is usually a benign self-limited illness, characterized by regional lymphadenopathy lasting between 3 and 6 weeks. The causative organism is Bartonella henselae, a small gram-negative rod. Between 1 and 2% of patients who contract the illness experience blurred vision, metamorphopsia and scotomas as a result of neuroretinitis, an associated clinical syndrome. The classical clinical findings in cat-scratch neuroretinitis include disc edema and a stellate pattern of exudates in the macula. However, a myriad of other signs has been documented, suggesting a much wider spectrum of intra-ocular disease. The following case report presents a young patient with neuroretinitis, and a history of lymphadenopathy secondary to cat-scratch disease.
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PMID:Neuroretinitis: a clinical syndrome of cat-scratch disease. 1113 30

We report on 2 patients with ophthalmologic complications associated with mild iron deficiency anemia. Case 1, a 37-year-old female patient, presented after 4 days of blurred vision in her left eye. Ophthalmoscopic and angiographic findings were consistent with the diagnosis of central retinal vein occlusion (CRVO). Further hematologic investigation into possible causes disclosed mild iron deficiency anemia (Hb 9.4 g/dl, hematocrit 30.5%). After the patient's visual acuity had worsened progressively to 20/50, an initial thrombolytic treatment and continuous intravenous heparinization was started on day 8, followed by oral substitution therapy with ferrous sulfate. On day 14, her visual acuity recovered to 20/20 OS and remained stable during follow-up. Case 2, a 50-year-old female patient, presented with a 1-week-history of blurred vision and metamorphopsia. Her visual acuity was 20/200. Further examination revealed a nonarteritic ischemic optic neuropathy and an iron deficiency anemia as the underlying disease (Hb 7.3 g/dl, hematocrit 25%). Despite intravenous heparinization and systemic treatment with steroids, there was no improvement in visual acuity. Clinicians involved in the management of chronic iron deficiency anemia should be aware of possible ophthalmic manifestations in this disease.
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PMID:Central retinal vein occlusion and nonarteritic ischemic optic neuropathy in 2 patients with mild iron deficiency anemia. 1124 44

Central serous chorioretinopathy (CSC) is a disease of the retina characterized by serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE). CSC occurs most frequently in mid-life and more often in men than in women. Major symptoms are blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the centre of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months. The condition can be precipitated by psychosocial stress and hypercortisolism. Ophthalmoscopic signs of CSC range from mono- or paucifocal RPE lesions with prominent elevation of the neurosensory retina by clear fluid - typical of cases of recent onset - to shallow detachments overlying large patches of irregularly depigmented RPE. The spectrum of lesions includes RPE detachments. Granular or fibrinous material may accumulate in the subretinal cavity. Serous detachment often resolves spontaneously. From first contact, counselling about the potential relation to stress and glucocorticoid medication is warranted. After 3 months without resolution of acute CSC or in chronic CSC, treatment should be considered. Resolution of detachment can usually be achieved in acute CSC by focal photocoagulation of leaking RPE lesions or, in chronic CSC, by photodynamic therapy. The effect of therapy on long-term visual outcome is insufficiently documented. Reattachment within 4 months of onset is considered a relevant therapeutic target because prolonged detachment is associated with photoreceptor atrophy. This suggests that the value of treatment depends upon proper selection of cases that will not resolve without therapy. Chronic CSC may be difficult to differentiate from occult choroidal neovascularization secondary to CSC. Patients with chronic CSC who receive glucocorticoid treatment for systemic disease can often be managed without having to discontinue this medication.
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PMID:Central serous chorioretinopathy. 1766 99

Central serous chorioretinopathy is a common disease of the retina, often mistaken for degeneration of the macula or uveitis. The disease is related to stress and treatment is with glucocorticoids, but it is also seen in connection with pregnancy. The disease can lead to permanent visual loss. Patients with blurred vision, metamorphopsia and micropsia should be examined by an ophthalmologist within 24 hours because the condition may involve treatment-eligible subretinal neovascularization.
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PMID:[Central serous chorioretinopathy]. 1853 64

The choroidal osteoma is a typically unilateral, benign ossifying tumor of the choroid. It is mostly located in the juxtapapillary area and usually found in females in the second or third decade of life. Most patients are asymptomatic. However, some can present with blurred vision, metamorphopsia, and visual field defects. Ultrasonography can show a calcified choroidal plaque with a typical shadowing posterior to the lesion. Fluorescein angiography and optical coherence tomography should be used if choroidal neovascularization is suspected as a possible complication of the choroidal osteoma.
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PMID:[Worsening of vision with apparent changes of the posterior pole]. 2127 Dec 54

Phosphodiesterase-5 (PDE5) inhibitors are commonly used in the treatment of erectile dysfunction. There are a small number of case reports that associate this agent with central serous chorioretinopathy (CSCR). Our report presents the treatment approach to a 42-year-old patient who described blurred vision and metamorphopsia and was diagnosed with CSCR following the use of tadalafil, a PDE5 inhibitor.
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PMID:Central serous chorioretinopathy due to tadalafil use. 2306 16


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