Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344232 (blurred vision)
 2,072 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Brain capillary telangiectasia (BCT) are usually small, solitary, benign in clinical manifestation, or found incidentally at autopsy. However, diffuse BCT are rarely reported. A 39-year-old woman had the first generalized seizure 10 years previously. Thereafter, she had sustained progressive spastic paraparesis and blurred vision. Computed tomography (CT) showed diffuse brain atrophy with numerous calcified spots. Contrast T1-weighted magnetic resonance images showed diffuse faintly enhancing lesions with stippled appearance in the whole brain. Cerebral angiography revealed multiple small nets of dilated capillaries and Xenon CT showed diffuse low cerebral blood flow in the resting and good cerebral reserve capacity in the acetazolamide challenge test. Therefore, diffuse BCT was diagnosed clinically. Although BCT are not rare, diffuse BCT with slowly progressive neurological symptoms had never been reported before. It causes global cerebral ischemia that lead to brain atrophy and a degenerative course.
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PMID:Diffuse capillary telangiectasia of the brain manifested as a slowly progressive course. 1249 24

Choroidal metastasis is a rare presenting feature of breast carcinoma. A 48-year-old woman presented with blurred vision of the right eye related to choroidal metastasis. Diagnostic work-up disclosed breast carcinoma with multiple metastases of the liver and lungs. Initial cerebral computed tomography scan was normal. During the follow-up, generalized seizure leaded to the diagnosis of multiple calcified cerebral metastasis. In 15 to 30 percent of cases, choroidal metastasis reveals a solid tumor, usually of the lung or the breast. Cerebral metastasis are common in breast cancer, but rarely calcified.
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PMID:[Choroidal metastasis as a presenting feature of breast carcinoma]. 1760 2