Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344232 (blurred vision)
 2,072 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fourteen patients with chronic pain of malignant origin were treated with escalating doses of THIP intramuscularly 5-30 mg in an open phase 1 study. Analgesic activity was demonstrated in 60% of the patients at the level of 20 mg THIP and a dose response relation was present. Side effects, sedation, dizziness, euphoria, nausea, and blurred vision were present in up to 80% of the patients and were dose limiting. The maximum serum concentration was reached within 1 h after dosing in 87% of all administrations. Mean t1/2 was 1.52 +/- 0.63 h and the clearance was 0.49 +/- 0.181 min. Significant correlations were demonstrated between serum concentration, dose of THIP, analgesic effect and side effects. It is concluded that THIP cannot be used for the treatment of chronic cancer pain, not because of insufficient analgesic effect but because of unacceptable side effects.
 ...
PMID:The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study. 663 33

This case report is of a 46-year-old patient who developed blurred vision shortly following an opiate pump (Drug Administration System, DAS) placement for chronic pain due to chronic lumbar radiculopathy and a multiply operated spine. Following the implant she complained of positional headaches and blurred vision. The headache gradually subsided with rehydration. However, one week after the pump placement she continued to complain of blurred vision and diplopia. Neurologic examination revealed left lateral rectus palsy. A neurologist was consulted who confirmed the diagnosis. The symptoms gradually abated.
 ...
PMID:Lateral rectus palsy: complication following opiate pump placement. 1686 24

Intrathecal drug delivery is a widely used and effective method of treatment for chronic intractable pain. Unfortunately all currently used agents can not provide adequate pain relief in all patients. A prospective study of neuroaxial methadone was performed in 24 patients, all of whom had failed treatment with multiple previous intrathecal drugs. Thirteen patients experienced improvement of their pain control with methadone, nine continued to receive this agent for 6 months with good pain relief, improved quality of life and no side effects. The final rates of methadone infusion were 2.2 times higher than preceding morphine rates. The only observed possible side effect of methadone was transient blurred vision in one patient. Methadone is a promising alternative neuroaxial agent in the treatment of chronic pain.
 ...
PMID:Methadone in the intrathecal treatment of chronic nonmalignant pain resistant to other neuroaxial agents: the first experience. 2215 68

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications because they provide effective relief of chronic pain and inflammation through inhibition of cyclooxygenase (COX). However, visual side effects also have been reported, such as temporary blindness, visual field defect, blurred vision, scotomata, and color vision changes subsequent to short- or long-term use. Our aim was to investigate the effect of a high dose of meclofenamic acid (MFA) on the retina. In our study, we applied electroretinography (ERG) and histologic examination to study functional and morphological damage of the retina in rabbits after MFA treatment. We reveal that MFA markedly decreased the amplitudes of b-wave of Rod-response and a- and b-wave of the scotopic standard combined ERG, respectively, and induced morphological destruction of the retina, especially photoreceptor cells. We conclude that a high dose of MFA causes retinal toxicity and impairs visual transduction. These findings may explain, at least partially, the vision problems of certain clinically used NSAIDs.
 ...
PMID:Retinal toxicity associated with high dose of meclofenamic acid. 2353 49

Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eye-associated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.
...
PMID:Neuropathic ocular pain: an important yet underevaluated feature of dry eye. 2537 19