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Query: UMLS:C0344232 (blurred vision)
 2,072 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 30 year old man with Hodgkin's disease, clinically in remission, presented with blurred vision in one eye due to a choroiditis. He developed headaches 10 days after commencing oral steroids and was subsequently found to have cryptococcal meningitis. The meningitis and choroiditis resolved on antifungal medication. This is the first case of cryptococcal choroiditis recorded in the United Kingdom.
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PMID:Cryptococcal choroidoretinitis and immunodeficiency. 345 Dec 21

A 12-year-old girl had blurred vision and pain behind her left eye for three months. An examination disclosed focal choroiditis and optic nerve edema. Her visual acuity was 20/30. Two similar previous episodes had been diagnosed as scleritis and uveitis and the patient was still on a regimen of 5 mg of prednisone per day and eyedrops containing prednisolone and phenylephrine. A pink choroidal mass superotemporal to the optic disk was negative for calcium by computed tomography and ultrasonography. The corticosteroids were discontinued. Three months later, the patient's visual acuity had improved to 20/20 but the choroidal lesion was slightly larger and two new lesions had appeared, one just above the optic disk and the other superotemporal to the macula. Three years later the two new lesions had coalesced to form one lesion with vascular channels on its surface. Although a choroidal osteoma was suspected, computed tomography and ultrasonography were still negative for calcium. Five years after the initial examination, computed tomography showed a thin ring of calcium within the choroid at the location of the mass. Ultrasonography also confirmed the presence of calcium.
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PMID:Choroidal osteoma after intraocular inflammation. 641 17

Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele. The absence of ocular trauma or previous intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential diagnosis. The disease has an acute onset of bilateral blurred vision with hyperemia preceded by flu-like symptoms. The acute uveitic stage is characterized by a diffuse choroiditis with serous retinal detachment and optic disc hyperemia and edema. Fluorescein angiography in this phase demonstrates multiple early hyperfluorescent points. After the acute uveitic stage, ocular and integumentary system pigmentary changes may appear. Ocular findings may be accompanied by lymphocytic meningitis, hearing impairment and/or tinnitus in a variable proportion of patients. Prompt diagnosis followed by early, aggressive and long-term treatment with high-dose corticosteroids is most often ensued by good visual outcomes. However, some patients may experience chronic uveal inflammation with functional eye deterioration. The current review discusses the general features of VKHD, including epidemiology, classification into categories, differential diagnosis and current therapeutic approaches.
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PMID:Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. 2700 48

The purpose of this study is to present a case with serpiginoid choroiditis with possible ocular tuberculosis. The intraocular inflammation and choroiditis were successfully controlled by systemic antituberculosis treatment. A 63-year-old female presented with progressive bilateral blurred vision for over a year. At presentation, her best-corrected visual acuity was 6/20 in her right eye and counting fingers at 10 cm in her left eye. A fundus examination showed diffuse patchy geographic retinal pigment epithelium (RPE) changes with some pigmentation in both eyes. Fluorescein angiography disclosed leakage from RPE lesions and discs as well as retinal vasculitis. Systemic survey results for rheumatic and infectious diseases were normal except for a positive QuantiFERON-TB Gold test result. Her uveitis improved and chorioretinal lesions stabilized from the 2nd month of antituberculosis treatment. The antituberculosis treatment was discontinued after a 12-month course. No recurrence of uveitis was noted during the following 2 months. Diagnosing ocular tuberculosis is challenging. The clinical presentation, interferon-gamma release assay test, and clinical response to antituberculosis therapy can support a presumed diagnosis of tubercular uveitis. This case highlights that serpiginoid choroiditis can be a clinical presentation of ocular tuberculosis. Clinicians should pay attention to this etiology when facing a serpiginous-like retinal appearance.
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PMID:Serpiginoid choroiditis associated with presumed ocular tuberculosis. 3119 73