Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0343525 (Lemierre's syndrome)
 443 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lemierre syndrome, also known as postanginal septicemia, has long been taken as an uncommon condition with life-threatening potential. It, resulting from acute oropharyngeal infection, could lead to septic thrombophlebitis of the internal jugular vein (IJV). Substantial decrease of mortality and morbidity with the introduction of antibiotics has made this syndrome into a status that is frequently forgotten or overlooked when it appears. The purpose of this article is to refresh awareness on the side of physicians of this syndrome by means of modern image tools. As such, even this dire neck infection is rare after the advent of sophisticated antibiotics, its unique computed tomography findings can facilitate the correct image diagnosis and pertinent treatment.
 ...
PMID:Computed tomographic findings in Lemierre syndrome. 1555 3

Postanginal sepsis, also called Lemierre's syndrome, is a rare but acute medical condition complicating oropharyngeal infection. The pathogenesis consists of the development of internal jugular vein septic thrombophlebitis leading to metastatic infections in the lung and other sites. The causative microorganism is most often Fusobacterium necrophorum. We present three patients with Lemierre's syndrome who presented to the Leiden University Medical Center and give a review of the literature.
 ...
PMID:Lemierre's syndrome: three cases and a review. 1559 53

Lemierre syndrome (also called post-anginal sepsis or necrobacillosis) is an uncommon complication of oropharyngeal infections for which early recognition and aggressive therapy is mandatory, since it is potentially life-threatening. Due to it's rarity, with a prevalence of 0.8 cases per million in the general population, many physicians are unfamiliar with this disorder. This is attested by the fact that diagnosis most often relies on bacteriological grounds. We report the case of a patient whose diagnosis of thrombophlebitis of the internal jugular vein was made by the emergency physicians based upon clinical presentation, allowing for prompt initiation of adequate antibiotherapy. The aim of this report is to enhance general practitioner's and emergency physicians' awareness of this uncommon disorder, which should always be suspected in case of sepsis following an oropharyngeal infection.
 ...
PMID:[Lemierre syndrome: a diagnosis to keep in mind]. 1563 Nov 68

Lemierre's syndrome (LS) is an uncommon but potentially life-threatening complication of an anaerobic oropharyngeal infection, affecting young adults and adolescents. The disease is characterised by a septic thrombophlebitis of the internal jugular vein and "metastatic" infections, which can be followed by fulminant sepsis and rapid death. More recently, it has been reported a recrudescence of this condition, which could be attributable to alterations in antibiotic usage patterns. The authors report the case of a LS secondary to a bout of intense cough, a cause not yet described in the literature, highlighting the importance of a quick diagnosis and the institution of an appropriate therapy.
 ...
PMID:[Lemierre's syndrome]. 1573 75

Lemierre syndrome is a disease that presents with oropharyngeal infection, sepsis, internal jugular vein thrombosis, and septic emboli with the Gram-negative organism Fusobacterium necrophorum cultured as the etiologic agent. Clindamycin, metronidazole and ampicillin-sulbactam are effective antibiotic treatments, although the length of treatment has not been firmly established. The syndrome is seen less frequently in the current age of antibiotics. It is important, however, that physicians be aware of the syndrome as initiation of prompt antibiotic therapy, including anaerobic coverage, is essential for avoiding morbidity and mortality. We describe a case of Lemierre syndrome.
 ...
PMID:Lemierre syndrome. 1576 72

Classical Lemierre's syndrome is characterized by severe sepsis with metastatic abscess formation in young, previously fit people from a primary head or neck focus. The causative organisms are the anaerobic fusobacteria, most commonly Fusobacterium necrophorum. We describe the evaluation, therapeutic interventions and management of a patient with Lemierre's syndrome who presented in septic shock with multiple organ dysfunction. The patient required immediate interventions including endotracheal intubation and mechanical ventilation, fluid resuscitation, inotropic support, bilateral thoracostomy tube drainage of empyemata and antimicrobial therapy. The unexpected isolation of Fusobacterium necrophorum from blood cultures and empyema fluid necessitated a change of antibiotic regime to provide anaerobic cover. The patient required 4 weeks of intensive support including prolonged antimicrobial therapy, and after a further 2 weeks was discharged home from hospital. This case highlights the need to raise the awareness of 'the forgotten disease': Lemierre's syndrome. Its diagnosis may, as in this case, be confounded by a lack of symptoms of pharyngitis at the time of presentation, and end-organ dysfunction associated with severe sepsis, possibly suggesting an alternative source of infection. As appropriate antibiotics reduce mortality dramatically, clinicians need to be alert to Lemierre's syndrome and include it in the differential diagnosis in young but otherwise healthy patients presenting with severe sepsis.
 ...
PMID:Fusobacterium necrophorum-induced sepsis: an unusual case of Lemierre's syndrome. 1577 9

An unusual case of tonsillitis which showed progression to this rare syndrome despite treatment with intravenous antibiotics. Lemierre's syndrome is a rare condition characterised by a triad of: sepsis, thrombophlebitis of the internal jugular vein along with pleuropulmonary and/or distant metastatic abscesses. Diagnosis rests on a high index of suspicion and is confirmed by culture of Fusobacterium spp. from blood or infected sites. Radiological investigations are established aids for confirmation of diagnosis. Treatment is with appropriate antibiotics for at least 6 weeks and surgical drainage of abscesses if required. This case has been presented to highlight the mode of presentation, diagnostic tools employed and the management of the complications that featured in this condition.
 ...
PMID:Lemierre's syndrome: the link between a simple sore throat, sore neck and pleuritic chest pain. 1605 93

Lemierre syndrome is characterized by pharyngitis followed by Fusobacterium necrobacillosis sepsis complicated by internal jugular vein thrombosis and infectious metastatic abscesses. It has been considered to be a rare disease until the last decade when a larger number of cases have been reported. We discuss a case of Lemierre syndrome in a 17-year-old girl and review the pathophysiology of Fusobacterium necrobacillosis and diagnosis and treatment of Lemierre syndrome.
 ...
PMID:Lemierre syndrome. 1616 Jun 63

Septic phlebitis of the internal jugular vein, Lemierre's syndrome, is extremely rare. However, Lemierre's syndrome may cause septic pulmonary emboli or result in fatal systemic sepsis, or both, if a timely diagnosis and appropriate treatment are not provided. We present a case of Lemierre's syndrome that occurred in an otherwise healthy young man. In this case, progression to a moribund state was rapid, and surgical intervention proved lifesaving.
 ...
PMID:Lemierre's syndrome: a potentially fatal complication that may require vascular surgical intervention. 1627 66

The Lemierre syndrome or 'necrobacillosis' is a post angina sepsis caused by an acute oropharyngeal infection with a secondary thrombophlebitis of the internal jugular vein. There are often septic emboli in the lungs, although intestinal organs can also be affected. This syndrome is caused by the strictly anaerobic gram-negative pathogen Fusobacterium necrophorum, sometimes in combination with other pathogens. The patient typically presents with high fever, pain in the neck, malaise and dyspnoea one week after the start of an angina. Plain chest radiograph shows bilateral nodular infiltrates, ultrasound reveals a thrombophlebitis of the internal jugular vein. CT scan can be useful to confirm the diagnosis and possible complications. In the beginning there is often a transient hyperbilirubinemia with toxic inflammatory blood results. Under the correct antibiotic regime complete recovery can be obtained.
 ...
PMID:[The Lemierre syndrome: a complicated oropharyngeal infection]. 1627 97


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>