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Query: UMLS:C0343525 (Lemierre's syndrome)
 443 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lemierre's syndrome is an uncommon condition characterized by post-anginal septicemia due to anaerobes. Reported here is a case of Lemierre's syndrome presenting with thyroid and liver abscesses. At presentation, the 70-year-old female patient complained of fever, jaundice and neck pain. Computed tomography (CT) and ultrasound confirmed the presence of a left-sided internal jugular vein thrombosis as well as abscesses in the left thyroid lobe and the right lobe of the liver with pleural effusion. The thyroid abscess was treated with a left lobectomy.
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PMID:Case of Lemierre's syndrome presenting with thyroid abscess. 1525 46

Life-threatening necrotizing fasciitis and relapsing Lemierre syndrome associated with Fusobacterium necrophorum septicaemia occurred in young adults with a moderate Chron's disease and a missed profound IgA deficiency. This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease.
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PMID:Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infections. 1530 92

Lemierre syndrome, also known as postanginal septicemia, has long been taken as an uncommon condition with life-threatening potential. It, resulting from acute oropharyngeal infection, could lead to septic thrombophlebitis of the internal jugular vein (IJV). Substantial decrease of mortality and morbidity with the introduction of antibiotics has made this syndrome into a status that is frequently forgotten or overlooked when it appears. The purpose of this article is to refresh awareness on the side of physicians of this syndrome by means of modern image tools. As such, even this dire neck infection is rare after the advent of sophisticated antibiotics, its unique computed tomography findings can facilitate the correct image diagnosis and pertinent treatment.
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PMID:Computed tomographic findings in Lemierre syndrome. 1555 3

Postanginal sepsis, also called Lemierre's syndrome, is a rare but acute medical condition complicating oropharyngeal infection. The pathogenesis consists of the development of internal jugular vein septic thrombophlebitis leading to metastatic infections in the lung and other sites. The causative microorganism is most often Fusobacterium necrophorum. We present three patients with Lemierre's syndrome who presented to the Leiden University Medical Center and give a review of the literature.
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PMID:Lemierre's syndrome: three cases and a review. 1559 53

We report a case of an 8-year-old girl who presented with the clinical picture of Lemierre's syndrome (LS) secondary to bilateral mastoiditis. She developed unilateral sensorineural hearing loss (SNHL) along with internal jugular vein (IJV) thrombosis, septic arthritis of her ankle and cervical fasciitis. Combined antimicrobial, anticoagulant and surgical treatment helped reverse all the effects of the sequelae, including nearly all the hearing loss. This is a unique case of this uncommon variant of the syndrome and with an uncommonly reported complication. The literature indicates that pediatric cases are a minority and enforces that successful management rests on awareness of the condition, vigil and promptness of communication of a multidisciplinary pediatric team.
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PMID:A case of the otogenic variant of Lemierre's syndrome with atypical sequelae and a review of pediatric literature. 1562 59

Lemierre syndrome (also called post-anginal sepsis or necrobacillosis) is an uncommon complication of oropharyngeal infections for which early recognition and aggressive therapy is mandatory, since it is potentially life-threatening. Due to it's rarity, with a prevalence of 0.8 cases per million in the general population, many physicians are unfamiliar with this disorder. This is attested by the fact that diagnosis most often relies on bacteriological grounds. We report the case of a patient whose diagnosis of thrombophlebitis of the internal jugular vein was made by the emergency physicians based upon clinical presentation, allowing for prompt initiation of adequate antibiotherapy. The aim of this report is to enhance general practitioner's and emergency physicians' awareness of this uncommon disorder, which should always be suspected in case of sepsis following an oropharyngeal infection.
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PMID:[Lemierre syndrome: a diagnosis to keep in mind]. 1563 Nov 68

Lemierre's syndrome (LS) is an uncommon but potentially life-threatening complication of an anaerobic oropharyngeal infection, affecting young adults and adolescents. The disease is characterised by a septic thrombophlebitis of the internal jugular vein and "metastatic" infections, which can be followed by fulminant sepsis and rapid death. More recently, it has been reported a recrudescence of this condition, which could be attributable to alterations in antibiotic usage patterns. The authors report the case of a LS secondary to a bout of intense cough, a cause not yet described in the literature, highlighting the importance of a quick diagnosis and the institution of an appropriate therapy.
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PMID:[Lemierre's syndrome]. 1573 75

Lemierre syndrome is a disease that presents with oropharyngeal infection, sepsis, internal jugular vein thrombosis, and septic emboli with the Gram-negative organism Fusobacterium necrophorum cultured as the etiologic agent. Clindamycin, metronidazole and ampicillin-sulbactam are effective antibiotic treatments, although the length of treatment has not been firmly established. The syndrome is seen less frequently in the current age of antibiotics. It is important, however, that physicians be aware of the syndrome as initiation of prompt antibiotic therapy, including anaerobic coverage, is essential for avoiding morbidity and mortality. We describe a case of Lemierre syndrome.
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PMID:Lemierre syndrome. 1576 72

Presented here is the case of a 27-year-old male with atypical features of Lemierre's syndrome in which a definitive diagnosis was achieved using molecular methods. While routine investigations, including bacterial cultures, were unhelpful, two real-time PCR assays demonstrated Fusobacterium necrophorum-specific DNA in aspirates from brain and renal abscesses. This is the first report demonstrating that a laboratory diagnosis can be made using molecular methods in suspected cases of Lemierre's syndrome. Use of these methods can thus resolve diagnostic confusion, prevent unnecessary investigation, and direct specific antimicrobial treatment.
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PMID:Molecular diagnosis of Fusobacterium necrophorum infection (Lemierre's syndrome). 1577 52

Classical Lemierre's syndrome is characterized by severe sepsis with metastatic abscess formation in young, previously fit people from a primary head or neck focus. The causative organisms are the anaerobic fusobacteria, most commonly Fusobacterium necrophorum. We describe the evaluation, therapeutic interventions and management of a patient with Lemierre's syndrome who presented in septic shock with multiple organ dysfunction. The patient required immediate interventions including endotracheal intubation and mechanical ventilation, fluid resuscitation, inotropic support, bilateral thoracostomy tube drainage of empyemata and antimicrobial therapy. The unexpected isolation of Fusobacterium necrophorum from blood cultures and empyema fluid necessitated a change of antibiotic regime to provide anaerobic cover. The patient required 4 weeks of intensive support including prolonged antimicrobial therapy, and after a further 2 weeks was discharged home from hospital. This case highlights the need to raise the awareness of 'the forgotten disease': Lemierre's syndrome. Its diagnosis may, as in this case, be confounded by a lack of symptoms of pharyngitis at the time of presentation, and end-organ dysfunction associated with severe sepsis, possibly suggesting an alternative source of infection. As appropriate antibiotics reduce mortality dramatically, clinicians need to be alert to Lemierre's syndrome and include it in the differential diagnosis in young but otherwise healthy patients presenting with severe sepsis.
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PMID:Fusobacterium necrophorum-induced sepsis: an unusual case of Lemierre's syndrome. 1577 9


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