Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0338671 (Steroids)
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Human Gene/Protein
protein tyrosine phosphatase type IVA, member 1 11.7
zinc finger protein 36, C3H type-like 1 10.1
WNT1-inducible-signaling pathway protein 2 10.1
PAQR6 9.7
interleukin-22 binding protein 9.4
BAK1 protein 9.4
17beta-estradiol dehydrogenase 9.4
LY6/PLAUR domain containing 4 9.4
PAQR10 9.1
GABA transport protein 9.1
UDP-glucuronosyltransferase 1A10 8.9
PAQR9 8.9
truncated progesterone receptor 8.7
cytochrome P450 7B1 8.7
band 7 integral membrane protein 8.7
Helicase-like transcription factor 8.7
mPR 8.7
MNAR 8.5
HSD11 8.5
claudin 8 8.5
steroid 18-hydroxylase 8.5
GPER protein 8.3
DHHC-7 8.3
tyrosinase-like 8.2
20 alpha-hydroxysteroid dehydrogenase 8.2
17-ketoreductase 8.1
AKR1D1 8.0
Delta(5)-3-ketosteroid isomerase 8.0
estrone sulfatase 7.9
P450aldo 7.9
PAQR7 7.9
hyodeoxycholic acid 7.7
CYP39A1 7.7
PAQR5 7.6
PSN1 7.6
ABHD2 7.5
taxilin 7.5
serum and glucocorticoid regulated kinase 7.5
OATP3A1 7.4
PAIRBP1 7.4
SOAT2 7.4
GPR30 7.4
HSD3 7.4
CYP7B1 7.4
TFAM protein 7.3
ERp60 7.3
TTC37 7.3
sodium-dependent organic anion transporter 7.3
17 beta-hydroxysteroid dehydrogenase 7.2
SOAT 7.2
ORP2 7.2
Myc-associated zinc finger protein 7.2
SRD5A3 7.2
GPER 7.1
CRS2 7.1
G protein-coupled estrogen receptor 1 7.1
mSR 7.1
AKR1C4 7.1
Leu-16 7.1
OATP4A1 7.1
FIST 7.1
corticosteroid binding globulin 7.0
3 beta-hydroxysteroid dehydrogenase 7.0
progesterone receptor membrane component 2 7.0
RORalpha1 7.0
Estrogen sulfotransferase 7.0
PA28gamma 7.0
UGT2A1 7.0
C21 6.9
Hes6 6.9
delta 4 6.9
HSD17B3 6.9
PELP1 6.9
17beta-hydroxysteroid dehydrogenase 6.8
oxysterol 7alpha-hydroxylase 6.8
H-PGDS 6.8
ALG2 6.8
3 beta-HSD 6.8
UGT2B17 6.8
Niemann-Pick disease, type C1 6.8
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Disease
Steroids 11.7
Total fluid volume increased 11.7
Iatrogenic glaucoma 11.7
Pulmonary Lymphomatoid Granulomatosis 11.7
Anabolic Steroids 10.4
Sex cord-stromal tumor 10.1
Leptospiral uveitis 10.1
Diffuse Infiltrative Lymphocytosis Syndrome 10.1
Nasal sarcoidosis 10.1
Livedo vasculitis 9.7
Chronic thrombocytopenia 9.1
Acquired factor VIII deficiency 8.7
Sclerema 8.5
Chronic inflammatory disease 8.4
CMO II deficiency 8.3
Irreversible shock 8.1
Erosive adenomatosis of the nipple 8.1
Pleural adhesions 7.9
Steroid myopathy 7.9
Febrile ulceronecrotic Mucha-Habermann disease 7.8
pituitary cancer 7.8
Acute viral bronchiolitis 7.7
Subretinal hemorrhage 7.7
renal rickets 7.6
Bacterial keratitis 7.6
Chronic periaortitis 7.5
DEND 7.5
Autoimmune inner ear disease 7.3
Ophthalmoplegic migraine 7.3
Drug-induced immune hemolytic anemia 7.3
Diabetic maculopathy 7.2
IgG gammopathy 7.1
Pseudohypoaldosteronism 7.0
unable to remember 6.9
pigeon breeder's lung 6.9
Pretibial myxedema 6.9
11 beta-hydroxylase deficiency 6.7
adrenal disorder 6.7
Autoimmune enteropathy 6.7
Eosinophilic colitis 6.7
3 beta-HSD deficiency 6.7
Neonatal thrombocytopenia 6.7
Phrenic nerve palsy 6.6
Eosinophilic myocarditis 6.6
Granulomatous interstitial nephritis 6.5
Hypertrophic pachymeningitis 6.5
Retinal vasculitis 6.4
Lymphocytic colitis 6.4
NSIP 6.4
Diabetic macular edema 6.3
Steroid 21-hydroxylase deficiency 6.3
Multifocal motor neuropathy 6.3
T-cell lymphocytosis 6.3
oxyuriasis 6.2
HIVAN 6.2
Hypereosinophilic syndrome 6.2
viral keratitis 6.1
Vernal keratoconjunctivitis 6.1
Smith-Lemli-Opitz syndrome 6.1
congenital hypoplastic anemia 6.0
chronic bronchiolitis 6.0
Androgen excess 6.0
cystic ovary 6.0
cholesterol ester storage disease 5.9
drug induced lupus 5.9
Libman-Sacks endocarditis 5.8
recurrent thymoma 5.8
Legionella pneumophila pneumonia 5.8
Biotin deficiency 5.7
Juvenile dermatomyositis 5.7
obstructive airway disease 5.6
Orbital pseudotumor 5.5
Weingarten 5.5
Influenza A virus infection 5.5
Chronic inflammatory demyelinating polyradiculoneuropathy 5.5
Nonspecific interstitial pneumonia 5.5
erythrasma 5.4
Adrenal gland 5.4
Adrenal gland 5.4
acute bronchiolitis 5.4
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Symptom
Osteoarticular pain 10.1
Popeye sign 9.1
Sympathetically maintained pain 8.4
pain in the buttock 7.0
thoracic back pain 6.0
Cushingoid 5.0
elevated mood 5.0
Visual symptoms 4.9
Cushingoid 4.9
Visual disturbances 4.9
generalized erythema 4.8
Crushing 4.8
facial droop 4.7
masculinization 3.7
auditory hallucination 3.7
male subfertility 3.7
hot flashes 3.7
body pain 3.6
dark urine 3.6
adenitis 3.6
livedo 3.6
Physical findings 3.3
meningism 3.3
hyperacusis 3.2
sore throat 3.1
loss of balance 2.9
rhinorrhea 2.9
Halo 2.9
wheezing 2.8
otalgia 2.7
physical appearance 2.7
Catch 2.7
POA 2.7
menopausal symptoms 2.6
hyperemesis gravidarum 2.6
Fluctuation 2.5
hot flushes 2.4
sneezing 2.4
nasal discharge 2.3
groin pain 2.1
chest tightness 2.1
acute stress 2.1
stridor 2.1
arthralgia 2.1
renal colic 2.1
consciousness disturbance 2.0
neuralgia 1.9
respiratory distress 1.9
dysesthesia 1.8
Ill 1.7
chronic cough 1.7
dyspnea 1.7
shortness of breath 1.7
joint stiffness 1.7
muscle rigidity 1.6
Postoperative pain 1.6
myalgia 1.6
erythema 1.6
hypoproteinemia 1.6
nasal congestion 1.6
weakness 1.5
night sweats 1.5
pallor 1.4
tingling 1.4
neck pain 1.4
dry eye 1.4
anorexia 1.3
cachexia 1.3
lethargy 1.2
hoarseness 1.2
cough 1.2
HSA 1.2
anosmia 1.1
photophobia 1.1
nausea and vomiting 1.1
despair 1.1
torticollis 1.1
tinnitus 1.0
paresthesia 1.0
ophthalmoplegia 1.0
more...
Drug
Drostanolone 10.7
Diflorasone diacetate 10.1
Trimegestone 9.7
Squalamine lactate 9.7
Diflorasone 9.7
Ultravate 9.4
Winstrol 9.1
Kaempherol 9.1
Pregnenolone 8.4
Asoprisnil 8.1
Zemplar 8.1
Dramamine 8.0
Dexamethasone acetate 7.6
Equilin 7.4
Aromasin 7.3
Tibolone 7.2
Sincalide 7.2
Lipidex 7.1
Drospirenone 7.1
Imidan 7.1
Deflazacort 6.9
Potassium canrenoate 6.8
Compound 15 6.8
Implanon 6.7
R1881 6.7
Cellcept 6.7
Cellcept 6.7
DHT 6.6
DHT 6.5
Dienogest 6.5
Dihydrotestosterone 6.5
Dutasteride 6.5
2-Methoxyestradiol 6.3
Ortho Tri-Cyclen 6.3
Mevastatin 6.3
Estrogens 6.2
Finasteride 6.1
Sinefungin 5.9
Estriol 5.9
Gestodene 5.9
Compound 9 5.7
Beraprost sodium 5.7
EE2 5.5
Naftidrofuryl 5.5
Gallium nitrate 5.4
TES 5.4
Ergosterol 5.4
Mepolizumab 5.4
Compound 19 5.3
Carbenoxolone 5.1
Belimumab 5.1
MAP 5.1
Compound 16 5.0
Icodextrin 5.0
Basiliximab 5.0
Basiliximab 5.0
Trilostane 4.9
Intal 4.9
Levonorgestrel 4.9
ICI 4.9
Prednisolone 4.9
Norplant 4.9
Tenoxicam 4.7
FSH-beta 4.7
FSH-beta 4.7
Methylprednisolone 4.7
Pyridoxal phosphate 4.6
Avonex 4.6
Febuxostat 4.6
Prednisone 4.5
Sulphasalazine 4.5
Premarin 4.5
FSH-beta 4.4
Budesonide 4.4
CET 4.4
TMS 4.3
Bexarotene 4.3
Prograf 4.3
Fulvestrant 4.3
Adalimumab 4.2
more...
Enzyme
3(17)alpha-hydroxysteroid dehydrogenase 9.1
2-deoxyglucose-6-phosphate phosphatase 8.7
methylsterol monooxygenase 8.7
7alpha-hydroxysteroid dehydrogenase 8.7
5-DES 8.5
17-ketoreductase 7.7
steroid 5-alpha-reductase 7.7
steroid sulfotransferase 7.7
CYP39A1 7.5
CYP7B1 7.3
SMT2 7.3
11beta-hydroxysteroid dehydrogenase 7.3
20alpha-hydroxysteroid dehydrogenase 7.1
3alpha-hydroxysteroid dehydrogenase 7.0
steroid isomerase 6.9
5alpha-reductase 6.9
5alpha-reductase 6.9
camphor hydroxylase 6.9
steroid 17alpha-hydroxylase 6.8
SOAT 6.7
3beta-hydroxysteroid dehydrogenase 6.6
methionine decarboxylase 6.5
5beta-reductase 6.5
17beta-HSD 6.5
HSD 6.4
GGGT 6.4
17beta-HSD 6.4
ecdysone 20-monooxygenase 6.3
CYP8B1 6.2
squalene-hopene cyclase 5.8
21-hydroxylase 5.8
cytochrome P-450scc 5.7
DHAD 5.7
7-dehydrocholesterol reductase 5.6
leishmanolysin 5.5
cholesterol oxidase 5.5
cycloartenol synthase 5.4
estrogen sulfotransferase 5.4
estrogen sulfotransferase 5.4
GPI-specific phospholipase C 5.3
arylsulfatase 5.3
EC 2.6.1.16 5.2
hydroxyprostaglandin dehydrogenase 5.1
sulfatase 5.1
ferredoxin reductase 5.0
CYP7A1 4.9
tyrosine aminotransferase 4.8
15-hydroxyprostaglandin dehydrogenase 4.7
cholesterol esterase 4.6
catechol oxidase 4.6
adrenodoxin reductase 4.5
prostasin 4.5
UDP-glucosyltransferase 4.4
lanosterol 14alpha-demethylase 4.4
NMT 4.3
CYP27A1 4.2
squalene epoxidase 4.2
glycerol 3-phosphate dehydrogenase 4.1
PHT 3.8
SOR 3.7
phosphoglycerate dehydrogenase 3.4
poly(A) polymerase 3.3
proteinase-3 3.3
oxidosqualene cyclase 3.3
E-2 3.3
trypanothione reductase 3.2
nitrile hydratase 3.2
ACAT 3.2
nucleotide pyrophosphatase 3.2
3-hydroxy-3-methylglutaryl-CoA reductase 3.2
dihydropteridine reductase 3.0
caspase-4 3.0
beta-glucuronidase 3.0
phenol oxidase 3.0
DNase II 3.0
Protein 2 3.0
ferrochelatase 2.9
DMT 2.8
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.8
diacylglycerol kinase 2.8
more...
Compound
(1-aminocyclohexyl)methanol 11.7
C28H44O6 11.7
17beta-Hydroxyandrost-4-ene-3,11-dione 11.7
cholestane-2,3-diol 11.7
allyl diethyl phosphate 11.7
Pregnenolone acetate 11.7
21-Fluoroprogesterone 11.7
pregnane-3,17,20-triol 11.7
C28H44O6 11.7
3-(4-(bis(2-chloroethyl)amino)phenoxy)propanoic acid 11.7
pregn-2-en-20-one 11.7
17-hydroxyandrost-4-en-3-one 11.7
Pyridine-sulfur trioxide complex 11.7
Dimethyltestosterone 11.7
21-Hydroxypregnenolone 10.7
6-Oxoestriol 10.7
Cremophor-El 10.7
3-methoxyestra-1,3,5(10)-trien-17-one 10.7
Inokosterone 10.7
C8H12O2 10.7
3-hydroxypregnane-11,20-dione 10.7
methyl (triphenylphosphoranylidene)acetate 10.7
methyl (triphenylphosphoranylidene)acetate 10.7
16beta-Methylprogesterone 10.7
Inokosterone 10.7
Polypodine B 10.7
3-hydroxypregnane-11,20-dione 10.7
17-oxoestra-1,3,5(10)-trien-3-yl 10.7
Cholesterol myristate 10.7
Inokosterone 10.7
Dibutyltin oxide 10.7
17-oxoestra-1,3,5(10)-trien-3-yl 10.7
2-Methoxyestrone 10.7
Methylestradiol 10.7
C21H30O 10.7
Hellebrin 10.7
Uzarigenin 10.7
estra-1,3,5(10)-trien-17-one 10.5
androst-4-en-3-one 10.5
Trilobolide 10.4
Inokosterone 10.1
cholesta-1,4-dien-3-one 10.1
Varanic acid 10.1
2-methylglutamic acid 10.1
16beta-Hydroxyestrone 10.1
Drostanolone 10.1
C19H28O2 10.1
16alpha-Hydroxytestosterone 10.1
Thiocholesterol 10.1
21-Deoxycorticosterone 10.1
11-Epicortisol 10.1
C19H28O2 10.1
C10H12O4 10.1
diethyl cyanomethylphosphonate 10.1
19-Norandrosterone 10.1
androstan-17-one 10.0
androstan-17-one 10.0
5alpha-Androstane-3beta,17beta-diol 9.9
cholest-5-en-7-one 9.9
Epiandrosterone 9.9
pregna-1,4-diene-3,20-dione 9.8
pregna-1,4-diene-3,20-dione 9.8
androstan-3-one 9.8
Maculosin 9.7
androsta-4,9(11)-diene-3,17-dione 9.7
19-Hydroxytestosterone 9.7
C23H34O5 9.7
Androsterone glucuronide 9.7
11beta-hydroxyandrosterone 9.6
CDMT 9.6
undecanamide 9.5
C20H30O3 9.4
7alpha-Methyl-19-nortestosterone 9.4
spirost-5-en-3-ol 9.4
20-hydroxypregn-4-en-3-one 9.4
19-hydroxyandrost-4-ene-3,17-dione 9.4
Sarsasapogenin 9.3
16 alpha-hydroxyestrone 9.3
estr-4-ene-3,17-dione 9.3
cholan-24-oic acid 9.2
more...