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Query: UMLS:C0338671 (Steroids)
 9,479 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pseudomonas sp. ATCC 31752 grows aerobically on cattle bile in a fermenter utilising the bile acid conjugates as a carbon source. Under conditions of limited aeration several steroid catabolites accumulate and these were harvested in good yield. Evidence is presented to show that these compounds are the novel compounds 12 beta-hydroxy-4, 6-androsta diene-3, 17-dione (VII) and 7 alpha, 12 beta-dihydroxy-4-androstene-3, 17-dione (VIII) together with the known bile acid catabolites 7 alpha, 12 beta-dihydroxy-1,4-androstadiene-3, 17-dione (IV), 7 alpha-hydroxy-1, 4-androstadiene-3, 17-dione (V) and 12 beta-hydroxy-1, 4-androstadiene-3, 17-dione (VI).
Steroids 1981 Oct
PMID:The major neutral products of the aerobic catabolism of cattle bile by Pseudomonas sp. ATCC 31752. 731 55

Two D-homosteroids were isolated from the hydrolyzate of 5 beta-pregnane -3 alpha, 20 alpha-diol disulfate (II) when it was refluxed in 3N hydrochloric acid. The structures of these steroids have been elucidated as 17 alpha-methyl-D-homo-5 beta-androstane-3 alpha, 17a beta-diol (VI) and 17 alpha-methyl-17a beta-chloro-D-homo-5 beta-androstan-3 alpha-ol (VIII) by instrumental analyses. The former was identical with a synthetic specimen derived from 5 beta-pregnane-3 alpha, 20 beta-diol disulfate (IV) by uranediol rearrangement. The main hydrolyzates obtained were 17 alpha-ethyl-17 beta-methyl-18-nor-5 beta-androst-13-en-3 alpha-ol (V) and 5 beta-pregnane-3 alpha, 20 alpha-diol (III).
Steroids 1980 Jul
PMID:Clinical analysis on steroids. XII. Occurrence of D-homoannulation during the hot acid hydrolysis of 5 beta-pregnane-3 alpha, 20 alpha-diol disulfate. 741 59

The genetically modified Mycobacterium sp. BCS 396 strain has been used to transform sterols with stigmastane side chain in order to obtain 26-oxidized metabolites. beta-Sitosterol (I) was transformed to 4-stigmasten-3-one (II), 26-hydroxy-4-stigmasten-3-one (III), and 3-oxo-4-stigmasten-26-oic acid (IV), while stigmasterol (V) was converted to 4,22-stigmastadien-3-one (VI), 6 beta-hydroxy-4,22-stigmastadien-3-one (VII), 26-hydroxy-4,22-stigmastadien-3-one (VIII), 3-oxo-4,22-stigmastadien-26-oic acid methyl ester (IX), and 3-oxo-1,4,22-stigmastatrien-26-oic acid methyl ester (X) with that strain. In both beta-sitosterol and stigmasterol, 26-oxidation generates the R-configuration on C-25.
Steroids 1995 Sep
PMID:Microbial transformation of beta-sitosterol and stigmasterol into 26-oxygenated derivatives. 854 51

The conversion of pregna-4,9(11)-diene-17alpha,21-diol-3,20-dione 21-acetate (I) and 17,21-diacetate (VI) by Nocardioides simplex VKM Ac-2033D was studied. The major metabolites formed from I were identified as pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione 21-acetate (II) and pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione (IV). Pregna-4,9(11)-diene-17alpha,21-diol-3,20-dione (III) and pregna-1,4,9(11)-triene-17alpha,20beta,21-triol-3-one (V) were formed in minorities. Biotransformation products formed from VI were pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione 17,21-diacetate (VII), pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione 21-acetate (II), pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione (IV), pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione 17-acetate (VIII), pregna-1,4,9(11)-triene-17alpha,20beta,21-triol-3-one (V). The conversion pathways were proposed including 1(2)-dehydrogenation, deacetylation, 20beta-reduction and non-enzymatic migration of acyl group from position 17 to 21. The conditions providing predominant accumulation of pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione 21-acetate (II) from I and pregna-1,4,9(11)-triene-17alpha,21-diol-3,20-dione 17-acetate (VIII) from VI in a short-term biotransformation were determined.
Steroids 2003 May
PMID:Microbial conversion of pregna-4,9(11)-diene-17alpha,21-diol-3,20-dione acetates by Nocardioides simplex VKM Ac-2033D. 1279 92

Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence. A mechanism accounting for the formation of the new compounds was given. The in vitro antimicrobial activity of the new compounds were tested.
Steroids 2005 Mar
PMID:Synthesis of biologically active steroid derivatives by the utility of Lawesson's reagent. 1576 90

Hepatic space occupying lesions in childhood are a diagnostic challenge, as they are caused by a variety of malignant and nonmalignant disorders with a different prognosis and, of course, treatment. They are often misdiagnosed or diagnosed only after surgical resection. A 14-year-old boy presented with abdominal pain, evening-rise fever with loss of appetite and weight. The patient also developed jaundice after 2 months of above symptoms. Ultrasound of the abdomen showed an irregular infiltrative mass in segment IV of the liver. Gadobenate disodium magnetic resonance imaging done showed T1 hypointense and T2 hyperintense lesions in segment VIII of the liver with extension into porta with delayed enhancement suggestive of fibrous tumor. Liver biopsy showed extensive liver parenchymal fibrosis with a mixed inflammatory infiltrate with eosinophils. Bacterial, tubercular, and fungal culture of liver biopsy were negative. Although serum IgG4 levels were 7.88 g/L (N =1.9 g/L), IgG4 staining of liver biopsy was negative. The patient was started on prednisolone 1 mg/kg considering the diagnosis of inflammatory pseudotumor (IPT). Twenty days after starting the steroid, mass lesions were converted into multicystic abscess requiring antibiotics and pigtail drainage. On follow-up, patient had improved symptoms with mass lesions turned into small-sized abscess cavity. Hepatic IPTs are difficult to differentiate from malignant tumors, as they are rare and can have variable imaging findings. To avoid inadvertent surgery, histological confirmation of the hepatic mass is essential. Steroids should be used with caution with close follow-up to prevent iatrogenic complications, such as a chronic liver abscess.
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PMID:An Enigmatic Liver Mass in a Child. 3211


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