Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0338671 (Steroids)
 9,479 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adrenal gland homogenates from four different strains of mice were incubated with (4-14 C)-pregnenolone and a NADPH generating system. The most important androgen synthesized was dehydroepiandrosterone; testosterone and progesterone were synthesized to a lesser extent and the production of androstenedione was very low. The highest synthetic activities were found in the high mammary tumor strain of mice (C3H x RIII) Fl; they were increased by ovariectomy, particularly when performed at two months of age. In the other strains, they were lower, specially in the low mammary tumor strain C 57 BL. However, the 3 beta-hydroxysteroid dehydrogenase / delta 5, 4 isomerase activity was not modified by ovariectomy in the high mammary tumor strain whereas it was increased in the low mammary tumor strains. These results indicate that the androgen synthesis in mouse adrenal depends on factors such as age, sex, endocrine status (ovariectomy) but also on susceptibility to mammary tumor development.
Steroids 1982 Feb
PMID:In vitro pregnenolone metabolism by mouse adrenal gland: II-Biosynthesis of androgens. 646 48

Adrenal gland homogenates from four different strains of mice were incubated with (4-14C)-pregnenolone and a NADPH generating system. Although quantitative differences between high and low mammary tumor strains occured, all mice synthesized estrone. The highest aromatase activity was found 2 months after castration of the (C3H x RIII) F1 mice when castration was performed at 4 days of age; this activity was lower in the C3H mice and almost negligible in the RIII and C57BL mice.
Steroids 1980 Apr
PMID:In vitro pregnenolone metabolism by mouse adrenal gland: I-estrogen synthesis. 737 27