Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0314719 (dry eye)
 2,625 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
lacritin 12.0
lipocalin-interacting membrane receptor 12.0
LIM domain only protein 7 11.6
CST4 11.3
Sodium/hydrogen exchanger 11.2
ARHGEF19 11.2
B3GNT4 11.0
ALS2CL 11.0
ZMIZ2 11.0
SFTA3 10.6
OGFr 10.3
ELOVL3 10.3
BARX2 10.1
PRH2 10.1
MUC1/Y 10.0
lacrimal 9.7
cornulin 9.7
choroideremia-like 9.6
BCAN 9.5
MUC16 9.4
IL17R 9.4
ELOVL1 9.4
CPNE1 9.3
ELOVL7 9.2
ELG 9.2
PRH1 9.2
KRT4 9.1
kappa light chain variable region 9.1
tear lipocalin 9.1
SS-A 9.1
KIAA1109 9.0
Barx2 9.0
mucin 16 9.0
NP-I 9.0
SPRR1 9.0
opioid growth factor receptor 8.9
QR2 8.9
hornerin 8.9
ANXA11 8.8
annexin A11 8.7
SS-B 8.7
KIR3DP1 8.7
MUC5AC protein 8.6
HCE 8.6
semaphorin 7A 8.6
P2Y14 receptor 8.6
ATG101 8.6
parotid secretory protein 8.5
KRT13 8.5
carbonic anhydrase VI 8.5
MUC19 8.5
SMILE 8.4
GPR32 8.4
P2Y14 8.4
LILRA3 8.3
Hensin 8.3
Che-1 8.3
PLAA 8.3
CSNK1A1 8.3
PRDX5 8.2
HRD 8.2
mucin 5AC 8.2
XFS 8.2
PRP-3 8.1
GLRX5 8.1
small proline-rich protein 8.1
NLRP6 8.0
HLA-A*33 8.0
BRCC36 8.0
KIR3DL3 8.0
ectodysplasin A 8.0
IL1RA 8.0
NHE8 7.9
REP2 7.9
P2Y2 7.9
immunoglobulin kappa chain 7.9
FAM83H 7.8
PRG4 7.8
Plexin-A1 7.8
alpha-fodrin 7.7
more...
Disease
Dry eye sensation 13.6
Aqueous tear deficiency 13.2
Meibomian gland dysfunction 12.9
Chronic blepharitis 12.8
Rosacea keratitis 12.6
Perennial allergic conjunctivitis 12.6
Gingival ulceration 12.6
Papillary conjunctivitis 12.6
Ocular surface disease 12.3
Postoperative cystoid macular edema 12.0
dry eye syndrome 11.8
meibomitis 11.7
photophthalmia 11.6
Conjunctivochalasis 11.6
Ocular discomfort 11.4
Primary Sjogren's syndrome 11.1
keratoconjunctivitis sicca 10.9
blepharitis 10.5
Corneal anesthesia 10.4
Facial nerve paresis 10.4
shoulder tendonitis 10.4
Giant papillary conjunctivitis 10.2
Cyclic thrombocytopenia 10.1
blepharoconjunctivitis 10.1
chronic conjunctivitis 10.0
Band keratopathy 10.0
Atopic keratoconjunctivitis 9.9
Lattice corneal dystrophy 9.8
Barber-Say syndrome 9.7
Fourth nerve palsy 9.7
eyelid dermatitis 9.7
Annular erythema 9.7
Sjogren's syndrome 9.6
Neurotrophic keratopathy 9.6
xerostomia 9.4
KCS 9.4
Conjunctiva 9.3
Conjunctiva 9.3
Bullous keratopathy 9.3
xerophthalmia 9.3
sicca syndrome 9.3
dacryoadenitis 9.2
ophthalmic migraine 9.2
migratory arthritis 9.1
lagophthalmos 9.1
asthenopia 8.9
allergic conjunctivitis 8.9
canaliculitis 8.9
Salzmann 8.9
epiphora 8.8
episcleritis 8.8
trichiasis 8.8
keratopathy 8.7
macular fibrosis 8.6
viral conjunctivitis 8.6
photokeratitis 8.5
conjunctiva 8.5
keratoconjunctivitis 8.5
acute conjunctivitis 8.4
corneal ulcer 8.4
Epithelial ingrowth 8.4
Lymphocytic infiltration 8.4
Posner-Schlossman syndrome 8.2
Granulomatous angiitis 8.2
corneal degeneration 8.1
bacterial conjunctivitis 8.1
dacryocystitis 8.1
Necrobiotic xanthogranuloma 8.0
Congenital heart block 8.0
keratitis 8.0
viral keratitis 8.0
Vernal keratoconjunctivitis 8.0
scleritis 7.9
Linear scleroderma 7.9
scleromalacia 7.9
Mooren's ulcer 7.9
Stevens-Johnson syndrome 7.8
infectious conjunctivitis 7.8
chalazion 7.8
Dercum's disease 7.8
more...
Symptom
Mucosal dryness 13.6
dry eye 13.6
stinging eye 13.6
Dellen 11.0
bloodshot eyes 10.8
cracked lips 10.4
redness of the eyes 10.4
eye pain 9.0
abnormal taste 8.7
sinus pain 8.7
Bell's phenomenon 8.6
eye discharge 8.5
vaginal itching 8.5
photophobia 8.4
Vaginal dryness 8.4
blepharospasm 8.3
Cardiovascular symptoms 8.2
dry throat 8.2
sialectasis 8.0
Swallowing problems 8.0
blurred vision 7.9
Visual symptoms 6.8
dry skin 6.7
Visual disturbances 6.7
hyperacusis 6.7
vestibulitis 6.5
discomfort 6.4
discomfort 6.3
peri-menopausal 6.1
catarrh 6.0
pleuritic chest pain 6.0
periorbital edema 5.6
athetosis 5.5
visual hallucination 5.4
arthralgia 5.3
dysesthesia 5.3
chronic cough 5.2
thinning 5.1
loss of taste 5.0
bladder pain 5.0
stomach pain 4.6
joint stiffness 4.5
swollen joints 4.5
ataxic gait 4.5
decreased appetite 4.4
myalgia 4.3
neck stiffness 4.3
spasm 4.3
drooling 4.2
twitching 4.2
chest tightness 4.0
torticollis 3.9
menopausal symptoms 3.9
paresis 3.9
ophthalmoplegia 3.9
exertional dyspnea 3.8
wrist pain 3.8
livedo 3.8
numbness 3.8
asthenia 3.8
muscle cramps 3.7
orofacial pain 3.7
fatigue 3.6
hot flashes 3.5
Postoperative pain 3.5
urinary frequency 3.4
productive cough 3.4
hypoproteinemia 3.4
nasal congestion 3.4
rhinorrhea 3.4
facial pain 3.4
night sweats 3.3
dystonia 3.3
tingling 3.3
constipation 3.2
shortness of breath 3.2
erythema 3.1
hoarseness 3.0
dizziness 2.9
cough 2.8
more...
Drug
Evoxac 11.2
Lacrisert 11.0
Cevimeline 10.9
Loteprednol etabonate 10.6
C.M.C. 9.6
Rebamipide 9.5
Tafluprost 9.4
Naltrexone hydrochloride 9.3
Travoprost 9.2
Nepafenac 9.0
Oxybuprocaine 8.9
Nicardipine hydrochloride 8.8
Lisdexamfetamine dimesylate 8.4
Acuvue 7.9
Neoral 7.7
Polyacrylic acid 7.4
Sodium hyaluronate 7.2
Timolol maleate 7.1
Castor oil 7.0
Mizoribine 7.0
Diphenhydramine 6.9
Menthol 6.9
Timolol 6.8
Solcoseryl 6.7
Plavix 6.6
Ora 6.6
balanced salt solution 6.3
Latanoprost 6.3
Pilocarpine 6.2
Deferasirox 6.0
CTT 5.9
Tranilast 5.9
Mitomycin-C 5.9
Botox 5.9
NOV 5.8
Escitalopram 5.6
Cellulose acetate 5.5
Fluorescein 5.5
Ketorolac 5.4
Azithromycin 5.3
Fluorescein 5.3
Isotretinoin 5.2
Retinoic Acid 5.0
Modafinil 5.0
Tocilizumab 4.8
Diclofenac sodium 4.8
Finasteride 4.8
Honey 4.8
Clopidogrel 4.5
Dasatinib 4.3
CFS 4.2
Scopolamine 4.2
OTC 4.0
Bayer 3.9
Tacrolimus 3.9
Retinoic acid 3.8
ETS 3.8
Award 3.8
Gabapentin 3.8
Rituximab 3.7
Cetuximab 3.7
OTC 3.5
DHT 3.5
DHT 3.4
Aloe 3.3
Methylene blue 3.2
CCL 3.2
Alliance 3.2
Prednisolone 3.0
Bortezomib 3.0
Vitamin E 2.9
Docetaxel 2.8
p75 2.6
-deoxyadenosine 2.5
Estrogens 2.4
Albumin 2.3
Clonidine 2.3
Imatinib 2.3
Nitric Oxide 2.2
Forskolin 2.2
more...
Enzyme
retinal dehydrogenase 7.5
NQO2 6.0
TSP-1 5.8
cathepsin S 5.6
fatty acid elongase 5.6
proteinase-3 5.1
botulinum neurotoxin 4.7
aconitase 4.4
MTD 4.3
xanthine dehydrogenase 4.3
arylsulfatase A 4.3
NAT 4.2
lysozyme 3.9
MMP 3.8
GRK2 3.8
ALDH 3.8
lysin 3.5
caspase-1 3.5
matrix metalloproteinase 9 3.5
hexosaminidase 3.4
acyl-CoA synthetase 3.2
PCE 3.2
peroxiredoxin 3.2
tryptase 3.1
indoleamine 2,3-dioxygenase 3.1
Alternating 3.0
MIP 2.9
ceruloplasmin 2.8
MMP-3 2.8
ornithine transcarbamylase 2.8
PAM 2.7
DCF 2.6
cholesterol acyltransferase 2.6
NQO1 2.6
chondroitinase 2.5
aldehyde dehydrogenase 2.5
aldehyde dehydrogenase 2.5
aldehyde dehydrogenase 2.4
PDK1 2.4
caspase-8 2.4
transglutaminase 2.3
aldehyde dehydrogenase 2.2
SPC 2.2
phosphoinositide 3-kinase 2.0
sulfatase 1.9
aldehyde dehydrogenase 1.9
aldose reductase 1.9
calcineurin 1.8
enolase 1.7
arginase 1.7
carbonic anhydrase 1.7
phospholipase D 1.7
xanthine oxidase 1.5
lipoxygenase 1.5
PAH 1.5
phospholipase C 1.4
adenylate cyclase 1.3
caspase-3 1.2
pyruvate kinase 1.2
glutathione peroxidase 1.1
focal adhesion kinase 1.1
collagenase 1.0
lipase 1.0
GSK 0.8
mitogen-activated protein kinase 0.8
superoxide dismutase 0.7
caspase-9 0.7
DNase 0.7
succinate dehydrogenase 0.6
peroxidase 0.6
plasmin 0.4
MEK 0.4
endonuclease 0.4
AMP-activated protein kinase -0.1
PARP -0.2
catalase -0.2
trypsin -0.2
phospholipase A2 -0.2
neuraminidase -0.3
lactate dehydrogenase -0.3
more...
Compound
11(R)-HETE 10.6
Resolvin D2 10.0
Fluorometholone 9.5
Schisantherin A 9.0
Schisantherin A 9.0
Benzalkonium chloride 8.5
Neu5,9Ac2 8.1
15(S)-HETE 8.1
Allergan 8.0
Diadenosine tetraphosphate 7.8
Diphenhydramine 7.5
Esculetin 7.3
Rose Bengal 7.1
DR-1 7.1
Squalene 7.0
Menthol 6.8
Timolol 6.8
1,3,5-triazine-2,4-diamine 6.8
Menthol 6.7
Oltipraz 6.7
Oxybutynin 6.7
Retinyl palmitate 6.6
Botulinum toxin type A 6.5
Polydatin 6.4
Pilocarpine 6.3
Practolol 6.3
Palmitoleic acid 6.3
IBP 6.3
IBP 6.3
Filipin 5.9
Cyclosporine 5.9
Trehalose 5.8
12(S)-HETE 5.7
tetraphosphate 5.7
Azithromycin 5.7
Hydroxychloroquine 5.7
Acyl-CoA 5.6
Ketorolac 5.5
Trimethylamine N-oxide 5.4
5-HETE 5.4
TMA 5.3
TMA 5.3
Edaravone 5.2
Lip 5.1
NIDA 5.0
K19 5.0
SP-1 4.8
hyaluronic acid 4.7
TBS 4.7
Amantadine 4.6
Amantadine 4.6
PSP 4.6
AMD 4.6
Naltrexone 4.6
Carnosine 4.5
Amantadine 4.5
ECP 4.5
ECP 4.5
ECP 4.5
8-OHdG 4.5
Astaxanthin 4.5
HEMA 4.4
ASC 4.4
Lutein 4.4
Nicardipine 4.3
ANA 4.3
ANA 4.3
2-phenylethylamine 4.2
Amantadine 4.2
MPA 4.2
MPA 4.2
MPA 4.1
1,3,5-triazine 4.1
DES 4.1
1,3,5-triazine 4.1
Uracil 4.0
Metoprolol 4.0
Levamisole 4.0
Uridine 3.9
17-OHP 3.9
more...