Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0314719 (dry eye)
2,625 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
lacrimal 402
Sep 128
mucin 112
Mol 77
cytokine 69
TNF 52
IL-6 44
She 42
lamp 40
CD4 39
SS-A 34
IFN 31
lactoferrin 30
collagen 29
IL-17 28
lysozyme 26
rheumatoid factor 25
SSA 25
interferon 24
SSB 23
MUC5AC 22
SS-B 22
tumor necrosis factor 21
MMP-9 18
IL-8 17
lymphoid 17
chemokine 17
ATP 17
P2Y2 17
insulin 13
NOD 13
HLA-DR 13
MUC16 13
matrix metalloproteinase 12
gut 12
AQP5 12
CD8 12
MUC1 11
glycoprotein 11
HLA 10
caspase-3 10
lacritin 9
IgA 9
IgE 9
P2X 9
strabismus 9
MMP9 9
lectin 9
IL-13 9
IL-10 9
MRI 9
substance P 8
Cytokine 8
NLRP3 8
TSP 8
IL-1 8
p38 8
endoplasmic reticulum 8
polypeptide 8
IL-2 8
IL-4 8
Pseudomonas 8
fibronectin 8
corneal dystrophy 7
ANA 7
OCT 7
MUC4 7
interleukin-6 7
MHC 7
superoxide dismutase 7
tear lipocalin 7
clusterin 6
p65 6
TNF-alpha 6
cyclooxygenase 6
peroxidase 6
interferon gamma 6
B10 6
Ki-67 6
epidermal growth factor 6
more...
Disease
cornea 324
xerostomia 236
conjunctiva 172
dry eye syndrome 135
autoimmune disease 131
glaucoma 128
keratoconjunctivitis sicca 123
keratitis 107
cataract 105
Sjogren's syndrome 86
conjunctivitis 71
blepharitis 70
rheumatoid arthritis 65
graft-versus-host disease 60
diabetes 59
Cornea 56
Cornea 56
Meibomian gland dysfunction 53
uveitis 52
keratopathy 50
eye disease 48
intraocular pressure 46
cancer 44
macular degeneration 44
epiphora 43
blindness 42
systemic lupus erythematosus 41
keratoconjunctivitis 40
arthritis 36
diabetic retinopathy 33
pemphigoid 30
allergic conjunctivitis 30
Stevens-Johnson syndrome 30
tumor 28
pruritus 28
prolapse 27
vasculitis 26
xerophthalmia 26
cold 26
sicca syndrome 25
lymphoma 25
depression 24
Anterior 24
retinopathy 23
corneal ulcer 23
rosacea 22
diplopia 22
keratoconus 20
myopia 20
systemic disease 20
Syndrome 19
strabismus 19
neuropathy 19
astigmatism 19
PSS 18
lupus 17
aqueous humor 17
sarcoidosis 16
anterior uveitis 16
lagophthalmos 16
sialadenitis 15
connective tissue disease 15
ectropion 15
dysphagia 14
asthma 14
Parkinson's disease 14
scleritis 14
blepharoconjunctivitis 13
NOD 13
lupus 13
cystic fibrosis 13
scleroderma 12
chronic conjunctivitis 12
skin disease 12
lymphadenopathy 12
peripheral neuropathy 12
chronic pain 11
episcleritis 11
dehydration 11
psoriasis 11
more...
Symptom
dry eye 2625
discomfort 163
discomfort 159
pain 144
fatigue 53
photophobia 44
blurred vision 41
thinning 32
anesthesia 32
headache 27
blepharospasm 26
arthralgia 24
weakness 21
eye pain 16
cough 14
spasm 12
myalgia 11
dry skin 9
erythema 9
constipation 8
paresis 7
dystonia 7
nausea 7
dizziness 6
chronic cough 6
numbness 6
Ill 5
dyspnea 5
ophthalmoplegia 4
exertional dyspnea 4
regurgitation 4
back pain 4
shortness of breath 4
sleepiness 4
abdominal pain 3
dysesthesia 3
pleuritic chest pain 3
diarrhea 3
asthenia 3
hyperacusis 3
twitching 3
vomiting 3
bloodshot eyes 3
redness of the eyes 3
neck pain 2
menopausal symptoms 2
paresthesia 2
syncope 2
decreased appetite 2
tinnitus 2
torticollis 2
epigastric pain 2
tremor 2
insomnia 2
ataxia 2
cracked lips 2
joint stiffness 2
hoarseness 2
facial pain 2
Bell's phenomenon 2
functional recovery 2
eye discharge 2
rhinorrhea 2
spasticity 2
polydipsia 1
paraparesis 1
chest pain 1
vestibulitis 1
apathy 1
bladder pain 1
splenomegaly 1
stomach pain 1
stinging eye 1
loss of taste 1
nausea and vomiting 1
angina 1
abnormal taste 1
dry throat 1
pelvic pain 1
sialectasis 1
more...
Drug
Dermatol 16
Fluorescein 12
Diphenhydramine 10
balanced salt solution 10
Fluorescein 10
Rebamipide 9
Neoral 9
Asthma 8
IL-2 8
Pilocarpine 4
Timolol 4
CSF 4
Azithromycin 4
Monit 4
Cevimeline 4
Retinoic acid 4
Loteprednol etabonate 3
Honey 3
vitamin E 3
ROS 3
Rituximab 3
Gel 3
MAP 3
ETS 3
Menthol 3
Alliance 2
Dial 2
Leaf 2
lysine 2
CTT 2
Botox 2
Scopolamine 2
Albumin 2
Travoprost 2
ROC 2
DHT 2
Bayer 2
Isotretinoin 2
DHT 2
p75 2
Vitamin E 2
Clopidogrel 2
Tacrolimus 2
Award 2
Sodium hyaluronate 2
OTC 1
Dasatinib 1
Mizoribine 1
Biopolymers 1
Tafluprost 1
Docetaxel 1
CFS 1
Diclofenac sodium 1
Vitamin A 1
Tocilizumab 1
IFN-gamma 1
Evoxac 1
Nitric Oxide 1
CCL 1
Naltrexone hydrochloride 1
Gabapentin 1
Indomethacin 1
Retinoic Acid 1
Methylene blue 1
Plavix 1
NOV 1
Escitalopram 1
Estrogens 1
Acuvue 1
Modafinil 1
Aloe 1
Cellulose acetate 1
ascorbate 1
Asn 1
Tranilast 1
Deferasirox 1
Polyacrylic acid 1
-deoxyadenosine 1
CAM 1
Lisdexamfetamine dimesylate 1
more...
Enzyme
lysozyme 26
mitogen-activated protein kinase 14
superoxide dismutase 8
peroxidase 8
focal adhesion kinase 8
caspase-3 7
ERK 6
caspase-1 6
MMP 5
protein kinase 5
calcineurin 5
phospholipase C 4
adenylate cyclase 4
ACS 4
catalase 4
glutathione peroxidase 4
TSP-1 4
botulinum neurotoxin 4
hexosaminidase 3
MIP 3
aconitase 3
collagenase 3
caspase-8 3
ceruloplasmin 3
trypsin 3
NQO1 3
lipase 3
transglutaminase 2
aldehyde dehydrogenase 2
matrix metalloproteinase 9 2
aldehyde dehydrogenase 2
endonuclease 2
lactate dehydrogenase 2
aldehyde dehydrogenase 2
xanthine dehydrogenase 2
aldehyde dehydrogenase 2
carbonic anhydrase 2
peroxiredoxin 2
MMP-3 2
xanthine oxidase 2
lipoxygenase 2
tryptase 2
phosphoinositide 3-kinase 2
aldehyde dehydrogenase 2
MEK 2
cathepsin S 2
neuraminidase 1
PARP 1
chondroitinase 1
PAM 1
proteinase-3 1
PDK1 1
arginase 1
glutathione S-transferase 1
ACE 1
phospholipase D 1
arylsulfatase A 1
aspartate aminotransferase 1
NAT 1
indoleamine 2,3-dioxygenase 1
fatty acid elongase 1
GRK2 1
MTD 1
luciferase 1
DNase 1
caspase-9 1
proteasome 1
phosphodiesterase 1
alkaline phosphatase 1
phospholipase A2 1
SPC 1
GSK 1
Alternating 1
APC 1
succinate dehydrogenase 1
ornithine transcarbamylase 1
enolase 1
acyl-CoA synthetase 1
plasmin 1
sulfatase 1
more...
Compound
Clin 219
Dec 163
water 74
sodium 55
TNF 52
oxygen 48
DNA 29
hyaluronic acid 27
Cyclosporine 25
calcium 24
NIDA 18
retinoic acid 18
ATP 18
phenol 17
Rose Bengal 13
phosphate 13
Diphenhydramine 10
Allergan 10
Pac 9
PEG 9
acetate 9
sulfate 9
iodine 8
uridine 8
ANA 7
ANA 7
selenium 7
salt 7
nitrogen 7
vitamin D 7
iron 7
urea 7
glucose 7
Benzalkonium chloride 6
pyrimidine 6
hydrogen 6
pyrimidine 6
8-OHdG 6
serine 6
potassium 6
nitric oxide 6
cAMP 5
TMA 5
ammonium 5
creatinine 5
retinol 5
FK506 5
UTP 5
Trehalose 5
cysteine 5
TOF 5
Salt 5
TMA 5
SDS 5
Curcumin 5
Estrogen 5
silicon 5
Pilocarpine 4
Lip 4
GSH 4
ACS 4
ASC 4
adenosylmethionine 4
PEG 4
acrylic acid 4
Adrenal 4
methionine 4
ACS 4
GlcNAc 4
formaldehyde 4
TEM 4
CO2 4
Azithromycin 4
formaldehyde 4
Timolol 4
DHA 4
tetraphosphate 4
MTT 4
GSH 4
Progesterone 3
more...