Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0314719 (dry eye)
 2,625 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
lacrimal 402
Sep 128
mucin 112
Mol 77
cytokine 69
TNF 52
IL-6 44
She 42
lamp 40
CD4 39
SS-A 34
IFN 31
lactoferrin 30
collagen 29
IL-17 28
lysozyme 26
SSA 25
rheumatoid factor 25
interferon 24
SSB 23
SS-B 22
MUC5AC 22
tumor necrosis factor 21
MMP-9 18
chemokine 17
P2Y2 17
ATP 17
lymphoid 17
IL-8 17
HLA-DR 13
MUC16 13
insulin 13
NOD 13
CD8 12
matrix metalloproteinase 12
gut 12
AQP5 12
MUC1 11
glycoprotein 11
HLA 10
caspase-3 10
strabismus 9
P2X 9
IgA 9
MRI 9
MMP9 9
lectin 9
IL-10 9
lacritin 9
IgE 9
IL-13 9
TSP 8
endoplasmic reticulum 8
IL-1 8
polypeptide 8
fibronectin 8
Cytokine 8
NLRP3 8
Pseudomonas 8
IL-2 8
substance P 8
IL-4 8
p38 8
corneal dystrophy 7
ANA 7
interleukin-6 7
OCT 7
MHC 7
tear lipocalin 7
superoxide dismutase 7
MUC4 7
TRPM8 6
B10 6
cyclooxygenase 6
p65 6
interferon gamma 6
clusterin 6
epidermal growth factor 6
HCE 6
intercellular adhesion molecule 1 6
albumin 6
metalloproteinase 6
tumor necrosis factor alpha 6
VEGF 6
lipopolysaccharide 6
NMR 6
HRD 6
peroxidase 6
CD45 6
Ki-67 6
IL-23 6
TNF-alpha 6
MAPK 5
FPR2 5
SDS 5
TOF 5
melastatin 5
inducible nitric oxide synthase 5
FK506 5
selenoprotein P 5
MMP 5
kit 5
K10 5
IL-5 5
Fas 5
CD25 5
ALX 5
CCL2 5
nerve growth factor 5
calcineurin 5
Che-1 5
PBS 5
ankylosing spondylitis 5
elastin 5
alpha-fodrin 5
CD20 5
HO-1 4
VIP 4
syndecan 4
STAT 4
SAM 4
PEG 4
MMP-2 4
JNK 4
TLR4 4
SMILE 4
San 4
occludin 4
cystic fibrosis transmembrane conductance regulator 4
autoantigen 4
TEM 4
interferon-gamma 4
peroxisome proliferator-activated receptor 4
EGF 4
LC3B 4
aquaporin 4
pigment epithelium-derived factor 4
keratin 4
S100A8 4
cyclooxygenase-2 4
Ban 4
GSH 4
TRPV1 4
adhesion molecule 4
galectin-3 4
glutathione peroxidase 4
ERK1 4
reserved 4
ASC 4
ACS 4
IL6 4
CXCL9 4
MUC7 4
S100 4
axonal 4
platelet-derived 4
Fas ligand 4
adenylate cyclase 4
CXCL10 4
intercellular adhesion molecule-1 4
more...
Disease
cornea 324
xerostomia 236
conjunctiva 172
dry eye syndrome 135
autoimmune disease 131
glaucoma 128
keratoconjunctivitis sicca 123
keratitis 107
cataract 105
Sjogren's syndrome 86
conjunctivitis 71
blepharitis 70
rheumatoid arthritis 65
graft-versus-host disease 60
diabetes 59
Cornea 56
Cornea 56
Meibomian gland dysfunction 53
uveitis 52
keratopathy 50
eye disease 48
intraocular pressure 46
macular degeneration 44
cancer 44
epiphora 43
blindness 42
systemic lupus erythematosus 41
keratoconjunctivitis 40
arthritis 36
diabetic retinopathy 33
pemphigoid 30
Stevens-Johnson syndrome 30
allergic conjunctivitis 30
pruritus 28
tumor 28
prolapse 27
xerophthalmia 26
cold 26
vasculitis 26
lymphoma 25
sicca syndrome 25
Anterior 24
depression 24
retinopathy 23
corneal ulcer 23
rosacea 22
diplopia 22
systemic disease 20
keratoconus 20
myopia 20
astigmatism 19
Syndrome 19
strabismus 19
neuropathy 19
PSS 18
lupus 17
aqueous humor 17
anterior uveitis 16
lagophthalmos 16
sarcoidosis 16
ectropion 15
connective tissue disease 15
sialadenitis 15
dysphagia 14
scleritis 14
asthma 14
Parkinson's disease 14
blepharoconjunctivitis 13
cystic fibrosis 13
lupus 13
NOD 13
scleroderma 12
lymphadenopathy 12
peripheral neuropathy 12
chronic conjunctivitis 12
skin disease 12
trichiasis 11
hypertension 11
chronic pain 11
malnutrition 11
psoriasis 11
stroke 11
migraine 11
dehydration 11
hypergammaglobulinemia 11
immunodeficiency 11
Orbit 11
episcleritis 11
HIV 11
multiple sclerosis 10
Raynaud's phenomenon 10
dacryocystitis 10
refractive error 10
hepatitis C 10
obesity 10
chronic disease 10
dacryoadenitis 10
Ocular surface disease 9
interstitial pneumonia 9
dysautonomia 9
proptosis 9
presbyopia 9
asthenopia 9
osteoporosis 9
facial palsy 9
AIDS 9
atopic dermatitis 8
Bell's palsy 8
endophthalmitis 8
infectious diseases 8
herpes simplex 8
acne 8
fibromyalgia 8
renal tubular acidosis 8
trachoma 8
renal failure 8
pneumonia 7
corneal dystrophy 7
mucosa-associated lymphoid tissue 7
B-cell lymphoma 7
interstitial nephritis 7
Epstein 7
sclera 7
rash 7
amyloidosis 7
ischemia 7
vitamin A deficiency 7
hyperopia 7
macular edema 7
cytomegalovirus 7
cognitive impairment 6
Best 6
vagina 6
seborrheic dermatitis 6
incontinence 6
gastritis 6
proteinuria 6
corneal edema 6
ankylosing spondylitis 6
confusion 6
photosensitivity 6
Graves' disease 6
Alzheimer's disease 6
polyneuropathy 6
inflammatory bowel disease 6
hepatitis 6
KCS 6
meibomitis 6
nystagmus 6
Hodgkin's disease 6
dermatomyositis 5
Graves' ophthalmopathy 5
hypovitaminosis 5
retinitis pigmentosa 5
hyperosmolality 5
melanoma 5
SDS 5
nephritis 5
interstitial cystitis 5
renal disease 5
more...
Symptom
dry eye 2625
discomfort 163
discomfort 159
pain 144
fatigue 53
photophobia 44
blurred vision 41
anesthesia 32
thinning 32
headache 27
blepharospasm 26
arthralgia 24
weakness 21
eye pain 16
cough 14
spasm 12
myalgia 11
erythema 9
dry skin 9
constipation 8
paresis 7
dystonia 7
nausea 7
dizziness 6
chronic cough 6
numbness 6
dyspnea 5
Ill 5
regurgitation 4
ophthalmoplegia 4
exertional dyspnea 4
sleepiness 4
back pain 4
shortness of breath 4
dysesthesia 3
pleuritic chest pain 3
diarrhea 3
redness of the eyes 3
asthenia 3
hyperacusis 3
vomiting 3
abdominal pain 3
twitching 3
bloodshot eyes 3
epigastric pain 2
paresthesia 2
syncope 2
tinnitus 2
torticollis 2
rhinorrhea 2
tremor 2
insomnia 2
eye discharge 2
facial pain 2
ataxia 2
joint stiffness 2
cracked lips 2
Bell's phenomenon 2
hoarseness 2
functional recovery 2
menopausal symptoms 2
decreased appetite 2
neck pain 2
spasticity 2
polydipsia 1
swollen joints 1
muscle cramps 1
chest pain 1
ataxic gait 1
vestibulitis 1
apathy 1
bladder pain 1
splenomegaly 1
stomach pain 1
stinging eye 1
loss of taste 1
nausea and vomiting 1
angina 1
abnormal taste 1
dry throat 1
pelvic pain 1
sialectasis 1
drooling 1
Mucosal dryness 1
dysarthria 1
sinus pain 1
productive cough 1
tachypnea 1
wrist pain 1
dysuria 1
nasal congestion 1
night sweats 1
acidity 1
Visual symptoms 1
Cardiovascular symptoms 1
Vaginal dryness 1
sore throat 1
visual hallucination 1
memory loss 1
tingling 1
flushing 1
analgesia 1
collapse 1
periorbital edema 1
seizures 1
athetosis 1
Dellen 1
heartburn 1
vaginal itching 1
hemiplegia 1
Swallowing problems 1
shoulder pain 1
hemoptysis 1
hepatomegaly 1
livedo 1
chest tightness 1
hepatosplenomegaly 1
distraction 1
orofacial pain 1
hip pain 1
neck stiffness 1
hot flashes 1
abdominal discomfort 1
acute pain 1
hypoproteinemia 1
bone pain 1
Visual disturbances 1
paraparesis 1
wheezing 1
oliguria 1
Postoperative pain 1
catarrh 1
peri-menopausal 1
urinary frequency 1
Drug
Dermatol 16
Fluorescein 12
Fluorescein 10
balanced salt solution 10
Diphenhydramine 10
Neoral 9
Rebamipide 9
Asthma 8
IL-2 8
Azithromycin 4
CSF 4
Timolol 4
Monit 4
Retinoic acid 4
Pilocarpine 4
Cevimeline 4
Honey 3
MAP 3
vitamin E 3
Rituximab 3
Loteprednol etabonate 3
ETS 3
ROS 3
Gel 3
Menthol 3
lysine 2
Vitamin E 2
CTT 2
Travoprost 2
Leaf 2
Tacrolimus 2
ROC 2
Scopolamine 2
Isotretinoin 2
DHT 2
p75 2
Botox 2
Alliance 2
Bayer 2
DHT 2
Dial 2
Clopidogrel 2
Award 2
Albumin 2
Sodium hyaluronate 2
OTC 1
Dasatinib 1
Mizoribine 1
Biopolymers 1
Tafluprost 1
Docetaxel 1
CFS 1
Diclofenac sodium 1
Vitamin A 1
Tocilizumab 1
IFN-gamma 1
Evoxac 1
Nitric Oxide 1
CCL 1
Naltrexone hydrochloride 1
Gabapentin 1
Indomethacin 1
Retinoic Acid 1
Methylene blue 1
NOV 1
Lacrisert 1
Escitalopram 1
Modafinil 1
Imatinib 1
Estrogens 1
Acuvue 1
Prednisolone 1
Ketorolac 1
Deferasirox 1
ascorbate 1
caffeine 1
Aloe 1
Asn 1
Tranilast 1
Latanoprost 1
Plavix 1
Polyacrylic acid 1
Oxybuprocaine 1
Cellulose acetate 1
Nepafenac 1
Lisdexamfetamine dimesylate 1
Solcoseryl 1
Castor oil 1
Clonidine 1
EPA 1
Bortezomib 1
citric acid 1
Timolol maleate 1
Forskolin 1
-deoxyadenosine 1
Cetuximab 1
CAM 1
Finasteride 1
OTC 1
Ora 1
Mitomycin-C 1
Nicardipine hydrochloride 1
CTX 1
C.M.C. 1
ampicillin 1
Enzyme
lysozyme 26
mitogen-activated protein kinase 14
peroxidase 8
focal adhesion kinase 8
superoxide dismutase 8
caspase-3 7
ERK 6
caspase-1 6
protein kinase 5
calcineurin 5
MMP 5
phospholipase C 4
glutathione peroxidase 4
catalase 4
TSP-1 4
ACS 4
botulinum neurotoxin 4
adenylate cyclase 4
collagenase 3
hexosaminidase 3
NQO1 3
aconitase 3
ceruloplasmin 3
MIP 3
trypsin 3
caspase-8 3
lipase 3
peroxiredoxin 2
transglutaminase 2
aldehyde dehydrogenase 2
matrix metalloproteinase 9 2
lactate dehydrogenase 2
MEK 2
aldehyde dehydrogenase 2
xanthine dehydrogenase 2
aldehyde dehydrogenase 2
phosphoinositide 3-kinase 2
aldehyde dehydrogenase 2
carbonic anhydrase 2
aldehyde dehydrogenase 2
endonuclease 2
MMP-3 2
xanthine oxidase 2
lipoxygenase 2
tryptase 2
cathepsin S 2
neuraminidase 1
PARP 1
chondroitinase 1
PAM 1
proteinase-3 1
PDK1 1
arginase 1
glutathione S-transferase 1
ACE 1
phospholipase D 1
arylsulfatase A 1
aspartate aminotransferase 1
retinal dehydrogenase 1
GRK2 1
cholesterol acyltransferase 1
lysin 1
AMP-activated protein kinase 1
fatty acid elongase 1
PAH 1
ALDH 1
luciferase 1
pyruvate kinase 1
MTD 1
NQO2 1
DNase 1
caspase-9 1
PCE 1
GSK 1
indoleamine 2,3-dioxygenase 1
NAT 1
enolase 1
proteasome 1
phosphodiesterase 1
alkaline phosphatase 1
phospholipase A2 1
SPC 1
Alternating 1
APC 1
succinate dehydrogenase 1
ornithine transcarbamylase 1
acyl-CoA synthetase 1
plasmin 1
sulfatase 1
creatine kinase 1
DCF 1
tyrosine hydroxylase 1
protein kinase C 1
aldose reductase 1
Compound
Clin 219
Dec 163
water 74
sodium 55
TNF 52
oxygen 48
DNA 29
hyaluronic acid 27
Cyclosporine 25
calcium 24
retinoic acid 18
ATP 18
NIDA 18
phenol 17
Rose Bengal 13
phosphate 13
Allergan 10
Diphenhydramine 10
sulfate 9
PEG 9
acetate 9
Pac 9
uridine 8
iodine 8
iron 7
glucose 7
nitrogen 7
urea 7
salt 7
vitamin D 7
selenium 7
ANA 7
ANA 7
pyrimidine 6
Benzalkonium chloride 6
pyrimidine 6
hydrogen 6
nitric oxide 6
potassium 6
serine 6
8-OHdG 6
creatinine 5
UTP 5
TMA 5
cAMP 5
cysteine 5
silicon 5
Curcumin 5
Trehalose 5
ammonium 5
TMA 5
TOF 5
SDS 5
FK506 5
Estrogen 5
retinol 5
Salt 5
Pilocarpine 4
methionine 4
ASC 4
ACS 4
GlcNAc 4
acrylic acid 4
PEG 4
GSH 4
ACS 4
Adrenal 4
DHA 4
CO2 4
Azithromycin 4
GSH 4
adenosylmethionine 4
tetraphosphate 4
Timolol 4
formaldehyde 4
TEM 4
formaldehyde 4
MTT 4
Lip 4
PAS 3
sodium chloride 3
Squalene 3
DHA 3
His 3
DHA 3
glycerol 3
Progesterone 3
lysine 3
Estrogen 3
Menthol 3
L-carnitine 3
Menthol 3
aldehyde 3
leucine 3
N-isopropylacrylamide 3
dUTP 3
Adenosine 3
arginine 3
ADP 3
ethanol 3
15(S)-HETE 3
Dexamethasone 3
BMC 3
betaine 3
5-HETE 2
N-acetylcysteine 2
UDP 2
PSP 2
tyrosine 2
CAT 2
Phe 2
aldehyde 2
chlorine 2
Dial 2
PVP 2
PEP 2
Hematoxylin 2
Substance P 2
CAT 2
diacetate 2
DBA 2
Vitamin E 2
MMC 2
HEMA 2
hydroxide 2
caffeine 2
H2S 2
Naltrexone 2
DBA 2
TCM 2
NO3 2
Acyl-CoA 2
Botulinum toxin type A 2
A 1 2
Tris 2
CAT 2
Off 2
TCM 2
MPA 2
ADP 2
UDP-glucose 2
zinc 2
DES 2
Rapamycin 2
ADP 2
MPA 2
carbonate 2
DHT 2
tryptophan 2
CCP 2
bromide 2
1,3,5-triazine 2
Hydroxychloroquine 2
MEK 2
Melatonin 2
DBA 2
Tris 2
PGE 2
HCl 2
AMD 2
more...