Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0314719 (dry eye)
 2,625 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The tear stability and tear volume of 55 asymptomatic Hong Kong-Chinese were assessed before soft contact lens (Hydron Zero 6) were and repeated on three visits over 28 weeks of lens wear. Soft lens wear caused a significant initial transient decrease in the non-invasive tear break-up time (NITBUT), but no change in tear volume as assessed by the self-prepared cotton thread test (SP-CTT) and phenol red thread (PRT) test. After 28 weeks, the subjects were classified according to the length of time they could wear their lenses without dry eye related signs and symptoms. The NITBUT and PRT tests were unable to predict the success of soft contact lens wear. However, the SP-CTT gave a sensitivity and specificity of 88.5 and 52.4%, respectively, in the prediction of subjects most likely to be successful wearers. The positive and negative predictive values at the chosen cut-off point were 69.7 and 78.6%, respectively. Wetting values, that is, combinations of NITBUT and SP-CTT values or NITBUT and PRT values, did not predict success in soft contact lens wear.
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PMID:Soft contact lens wear in Hong Kong-Chinese: predicting success. 1112 28

Two cotton thread tests (a self-prepared cotton thread test (SP-CTT) and the Phenol Red Thread (PRT) test) were performed on 46 dry eye and 37 normal Hong Kong (HK)-Chinese, all subjects being diagnosed by ophthalmologists in a private clinic. The mean SP-CTT value for the dry eye subjects (mean +/- SD: 6.2 +/- 4.2 mm/15s) was significantly lower than that of the normal subjects (8.3 +/- 4.3 mm/15s). However, no significant difference in the mean PRT value was found between the two groups (dry eye subjects: 10.7 +/- 4.5 mm/15s; normal subjects; 11.4 +/- 4.5 mm/15s). The specificity and sensitivity of the SP-CTT were 78.4% and 45.7 when a cut-off value of < or = 4 mm was used, and 56.8% and 65.2% when the cut-off value was changed to < or = 6.5 mm. Our results showed that the specificities and sensitivities of both tests were poor when applied to these dry eye patients.
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PMID:Evaluation of a self-prepared cotton thread test (SP-CTT) and the Phenol Red Thread (PRT) test. 1630 71