Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0312414 (Spotting)
 88 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of .35 mg of norethisterone/day on cervical mucus and on urinary luteinizing hormone (LH), pregnanediol, and estrogen levels were studied during 2 treatment cycles in 5 healthy women who had been observed during a control cycle. LH was measured by radioimmunoassay, total estrogens by a semiautomatic rapid method, and pregnanediol by a gas chromatographic method. There was some effect on the LH excretion patte rn in all the treatment cycles. Pregnanediol levels suggested ovulation in 3 cycles. In all 3 of these cycles the LH peak was lower and not as pronounced as in the respective control cycles. A patient with some initial suppression of LH and estrogens became pregnant during the trial. Cervical mucus was scanty, thick, opaque, and impenetrable to sperm throughout treatment. Spotting occurred in 4 of the treatment cycles, 2 of which were ovulatory. 3 possible ways in which norethisterone might exert its contraceptive effect are listed.
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PMID:The effect of daily norethisterone (0.35 mg) on cervical mucus and on urinary LH, pregnanediol and oestrogen levels. 103 19