Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0312414 (Spotting)
 88 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As part of a wider evaluation of the Multiload Copper 250 IUD, bleeding patterns were studied longitudinally during the 1st year following insertion in 150 women. The women were menstruating regularly and had not been pregnant or on hormone or intrauterine contraception in the preceding 2 months. Detailed counseling was given, including instruction on collection of menstrual data. The mean age of the patients was 28 years (19-35) and mean parity was 2-3; none was nulliparous. 12 subjects could not be contacted after insertion and were not considered further. At 12 months, there were 11 terminations: pain and/or bleeding, 2; other medical reasons, 1; accidental pregnancy, 1; planning pregnancy, 5f other personal reasons, 1; and lost to follow-up, 1. Following device insertion menstrual duration was initially increased, followed by a fall to levels which were not significantly different from preinsertion values after about 6-9 months of use. Similar trends were noted when menstrual bleeding and spotting were separately analyzed. The mean number of bleeding days decreased from 4.5 during the first 90 days to 4.2 and then 3.9, respectively, in the last 2 segments; the corresponding figures for menstrual spotting were 3.5, 2.8, 2.7, and 2.8 days. Intermenstrual bleeding and spotting were common after insertion but their frequency rapidly decreased with time. To a large extent, bleeding disturbances determine IUD acceptability. Thus, its perceived improvement would tend to encourage continued use and suggests that the potential risk of anemia in longterm users need not necessarily be serious.
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PMID:Menstrual flow duration and spotting following Multiload Copper 250 intra-uterine device insertion. 1227 48