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Query: UMLS:C0312414 (Spotting)
 88 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The action spectrum of an oral contraceptive which contained a reduced amount of the estrogen component (.04 ethinyl estradil and 2 mg lynestrenol) was investigated in 4 volunteer subjects. Serum levels of luteinizing hormone were determined by radioimmunoassay and, in addition, the karyopyknotic index and cervical function were studied daily from the 8th day of the cycle. These parameters were determined in a control cycle, in the cycle during administration of the oral contraceptive, and in the subsequent treatment-free cycle. Furthermore, the bleeding patterns were studied daily in 284 treatment cycles of 26 patients. Results of these studies indicate complete contraceptive protection by inhibition of ovulation and by an efficient cervical barrier action even during the 1st cycle of treatment. Withdrawal bleeding was observed 3-4 days after ingestion of the last tablet. Spotting was recorded in 11 subjects during the 1st treatment cycle, but was rarely observed during further treatment. Blood loss and bleeding control is comparable to that of other combined oral contraceptives with reduced estrogen content.
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PMID:[Central and peripheral actions of an oral contraceptive with reduced oestrogen content (author's transl)]. 85 49

208 Swiss and Finnish women took the progestagen-only minipills megestrol acetate .5 mg, chlormadinone acetate .5 mg, or D-norgestrel .03 mg for an average of 5 months. Withdrawal bleeding lasted longer, 5.2-5.3 days (mean) than with conventional pills, 4.6 days. Nausea occurred less frequently, 8.5% in the 1st cycle compared with 25%. Loss of libido was reported about as often as with sequential pills. Breakthrough bleeding at intervals of 21 days or less happened in 225 wi th chlormadinone, 28% with norgestrel, and 8% with megestrol. Spotting was reported in 27% of the cycles on megestrol, 18% on chlormadinone, and 14.5% on norgestrel. The time interval from 1 withdrawal bleeding to the next averaged 29.1 days with megestrol, 25.6 days with chlormadinone, and 24.5 days with norgestrel. The variance of this interval was comparable to the 3 progestagens, but about half as large in Finnish women as in Swiss, indicating that the dose used was too high in the Swiss population.
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PMID:[Experience with three minipills preparations with low dose progestagens for oral contraception]. 1230 10