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Query: UMLS:C0311277 (
abdominal obesity
)
2,792
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic pain
is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance, a marker of inflammation, and the presence of painful comorbidities as possible mediators of this association. Participants were 407 individuals aged >70 in the Einstein Aging Study.
Chronic pain
and pain over the last 3 months were defined using the Total Pain Index (TPI). Insulin resistance was modeled as fasting insulin, HOMA and QUICKI. High sensitivity C-reactive protein was used as a marker of inflammation. Cross-sectional logistic regression models were constructed to assess the associations of these factors with prevalent pain, adjusted for other known pain correlates. Prevalence of
chronic pain
was 52%. Of the clinical components of metabolic syndrome, central obesity was significantly associated with pain (OR 2.03, 95% CI 1.36-3.01). After adjustment for insulin resistance, inflammation, and pain-related comorbidities, central obesity predicted higher TPI scores (OR 1.55, 95% CI 1.04-2.33) and nearly doubled the risk of
chronic pain
(OR 1.70, 95% CI 1.05-2.75).
Central obesity
is the metabolic syndrome component showing the strongest independent association with pain, and the relationship is not explained by markers of insulin resistance or inflammation, nor by the presence of osteoarthritis or neuropathy.
...
PMID:Mechanisms of association between obesity and chronic pain in the elderly. 2095 30
Obesity and
chronic pain
are two major diseases of the 21th century. Our principal objective was to investigate the effects of a 4-week rehabilitation program on adiponectin and leptin concentrations, and insulin resistance, in patients with
abdominal obesity
and
chronic pain
syndrome. Our secondary objectives were to investigate the effects of this program on pain, body mass index (BMI), waist circumference and maximal oxygen consumption (VO
2max
) and to compare changes in VO
2max
between patients with or without insulin resistance. Among a consecutive sample of 128 patients with
abdominal obesity
hospitalized for rehabilitation for a
chronic pain
syndrome, 111 completed the protocol, which was a 4-week rehabilitation program including 6 hr of rehabilitation per day, 5 days per week, in a referral center of rehabilitation. This prospective cohort study compared clinical (BMI, waist circumference, VO
2max
, pain) and biological measures (concentrations of adiponectin, leptin and insulin, score of homeostasis model assessment of insulin resistance [HOMA]) before and after the program. Plasma leptin, adiponectin and insulin concentrations (
P
<0.0001) and score of HOMA (
P
=0.0002) had decreased significantly by the end of the 4 weeks. Pain, BMI and waist circumference decreased significantly, and VO
2max
improved significantly (
P
=0.0001). Patients with insulin resistance had less improvement of their aerobic condition at the end of the 4 weeks (
P
<0.002). The rehabilitation program decreases the concentration of leptin, and improves insulin sensitivity in patients with
chronic pain
and visceral obesity. Aerobic recovery was worse for patients with insulin resistance than other patients.
...
PMID:Visceral obesity and chronic pain: effect of a 4-week rehabilitation program on adipokines and insulin resistance. 2911 14
