Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0282612 (
PIN
)
2,291
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
p57(
Kip2
) has been considered a candidate tumor suppressor gene because of its location in the genome, biochemical activities, and imprinting status. However, little is known about the role of p57(
Kip2
) in tumorigenesis and cancer progression. Here, we show that the expression of p57(
Kip2
) is significantly decreased in human prostate cancer, and the overexpression of p57(
Kip2
) in prostate cancer cells significantly suppressed cell proliferation and reduced invasive ability. In addition, overexpression of p57(
Kip2
) in LNCaP cells inhibited tumor formation in nude mice, resulting in well-differentiated squamous tumors rather than adenocarcinoma. Furthermore, the prostates of p57(
Kip2
) knockout mice developed
prostatic intraepithelial neoplasia
and adenocarcinoma. Remarkably, this mouse prostate cancer is pathologically identical to human prostate adenocarcinoma. Therefore, these results strongly suggest that p57(
Kip2
) is an important gene in prostate cancer tumorigenesis, and the p57(
Kip2
) pathway may be a potential target for prostate cancer prevention and therapy.
...
PMID:Down-regulation of p57Kip2 induces prostate cancer in the mouse. 1848 41
