Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0282612 (
PIN
)
2,291
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The product of the
nm23-H1
gene has been reported to be related to the metastatic potential of several tumors. Although several studies have characterized the expression of the
nm23-H1
gene product in prostatic adenocarcinoma, little is known of the expression of this protein in
prostatic intraepithelial neoplasia
(
PIN
), a putative precancerous lesion. The authors used immunohistochemistry to examine the expression of the
nm23-H1
protein in
PIN
as well as benign and malignant prostatic tissue. A monoclonal antibody to
nm23-H1
(Novocastra, Newcastle upon Tyne, UK, clone 37.6) and a biotin/strepavidin detection system were used for antigen localization. Weak to moderate immunostaining was consistently detected in the benign glandular epithelium of 28 radical prostatectomy specimens. In contrast, strong immunostaining was detected in the glandular epithelium in
PIN
lesions of 19 radical prostatectomy specimens examined. Strong immunostaining was also frequently detected in the malignant cells of 39 localized prostatic adenocarcinomas, as well as 7 metastatic lesions. These findings show a phenotypic similarity of
PIN
to prostatic adenocarcinoma with respect to
nm23-H1
expression. Furthermore, strong expression of
nm23-H1
likely represents an early event in the development of prostatic adenocarcinoma.
...
PMID:Expression of nm23-H1 in prostatic intraepithelial neoplasia and adenocarcinoma. 889 85
