Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0282612 (PIN)
 2,291 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

PINOID, a serine threonine protein kinase in Arabidopsis, controls auxin distribution through a positive control of subcellular localization of PIN auxin efflux carriers. Compared with the rapid progress in understanding mechanisms of auxin action in dicot species, little is known about auxin action in monocot species. Here, we describe the identification and characterization of OsPID, the PINOID ortholog of rice. Phylogenetic analysis showed that the rice genome contains a single PID ortholog, OsPID. Constitutive overexpression of OsPID caused a variety of abnormalities, such as delay of adventitious root development, curled growth of shoots and agravitropism. Abnormalities observed in the plants that overexpress OsPID could be phenocopied by treatment with an inhibitor of active polar transport of auxin, indicating that OsPID could be involved in the control of polar auxin transport in rice. Analysis of OsPID mRNA distribution showed a complex pattern in shoot meristems, indicating that it probably plays a role in the pattern formation and organogenesis in the rice shoot.
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PMID:Characterization of OsPID, the rice ortholog of PINOID, and its possible involvement in the control of polar auxin transport. 1730 94

Recent years have seen important advances in understanding the Arabidopsis thaliana AGCVIII protein kinases D6 PROTEIN KINASE, PINOID/WAGs, and the phototropins. It has become apparent that these kinases control the distribution of the phytohormone auxin within the plant through phosphorylation of PIN-FORMED efflux carriers or of ABC transporters. Strikingly, D6PK and PID share the same phosphosites in PIN-FORMED proteins but have differential phosphosite preferences, which appear to control the activity and polar distribution of PIN-FORMED transporters. All three AGCVIII kinases are membrane-associated proteins that are dynamically transported to and from the plasma membrane. The implications of this dynamic transport for the activity and cell biological behavior of their phosphorylation substrates are just now starting to be understood.
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PMID:Dynamic control of auxin transport-dependent growth by AGCVIII protein kinases. 2530 15

Auxin is unique among plant hormones due to its directional transport that is mediated by the polarly distributed PIN auxin transporters at the plasma membrane. The canalization hypothesis proposes that the auxin feedback on its polar flow is a crucial, plant-specific mechanism mediating multiple self-organizing developmental processes. Here, we used the auxin effect on the PIN polar localization in Arabidopsis thaliana roots as a proxy for the auxin feedback on the PIN polarity during canalization. We performed microarray experiments to find regulators of this process that act downstream of auxin. We identified genes that were transcriptionally regulated by auxin in an AXR3/IAA17- and ARF7/ARF19-dependent manner. Besides the known components of the PIN polarity, such as PID and PIP5K kinases, a number of potential new regulators were detected, among which the WRKY23 transcription factor, which was characterized in more detail. Gain- and loss-of-function mutants confirmed a role for WRKY23 in mediating the auxin effect on the PIN polarity. Accordingly, processes requiring auxin-mediated PIN polarity rearrangements, such as vascular tissue development during leaf venation, showed a higher WRKY23 expression and required the WRKY23 activity. Our results provide initial insights into the auxin transcriptional network acting upstream of PIN polarization and, potentially, canalization-mediated plant development.
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PMID:WRKY23 is a component of the transcriptional network mediating auxin feedback on PIN polarity. 2937 85

Directional and non-directional environmental cues are able to induce polar behaviors of plants, which are termed tropic and nastic movements, respectively. While molecular mechanisms underlying the directionality of tropic movements are relatively well studied, it is poorly understood how the polarity of nastic movements is determined in response to non-directional stimuli, such as ambient temperatures. It has recently been shown that thermal induction of leaf hyponasty is stimulated by developmentally programmed polar auxin transport in Arabidopsis. Under warm environments, the PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) transcription factor binds to the promoter of PINOID (PID) gene, whose gene product modulates the polar trafficking of the auxin transporter PIN-FORMED 3 (PIN3). Notably, PIF4 binding to the PID promoter occurs predominantly in the abaxial petiole cells than the adaxial petiole cells, leading to differential PID expression and thus asymmetric auxin accumulation in the petiole cells. In addition, ASYMMETRIC LEAVES 1 (AS1), the well-characterized leaf polarity-determining epigenetic regulator, promotes the PID expression by modulating the patterns of histone 4 acetylation (H4Ac) in the PID chromatin. These observations demonstrate that developmental programming of the thermonastic leaf movement through polar auxin distribution enables plants to bend their leaves upward in response to non-directional thermal stimuli, contributing to cooling plant body temperatures under warm temperature conditions. We propose that a developmentally predetermined polarity plays a major role in governing the directionality of various nastic movements in plants.
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PMID:Developmental polarity shapes thermo-induced nastic movements in plants. 3108 57

Very recently, aggregation-induced emission (AIE) and two-photon (TP) emission materials have attracted great attention owing to their widespread applications. Herein, interestingly, we described a unique single fluorophore core with different substituents that can show either outstanding AIE or TP fluorescence properties. The introduction of an electron donating unit such as a tertiary amine group on the phenanthrenequinone imidazole core afforded a novel AIE-based fluorescent material PIN. The optical studies of PIN revealed that appropriate structural modifications on the phenanthrenequinone imidazole core could result in AIE character. On the other hand, modification of an electron-withdrawing moiety such as an indolium moiety on the same phenanthrenequinone imidazole-core provided a new material PID, which exhibited favorable TP emission, indicating that phenanthrenequinone imidazole derivatives could be exploited as TP materials. Furthermore, we have demonstrated that the novel AIE or TP materials constructed herein can be successfully applied for sensing targets of interest in aqueous and biological settings owing to their highly desirable emission profiles. The intriguing finding that careful modification of the phenanthrenequinone imidazole scaffold could afford excellent AIE or TP materials may open a new avenue to engineer robust materials with diverse properties based on a versatile core for various applications.
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PMID:Unique phenanthrenequinone imidazole-based fluorescent materials with aggregation-induced or two-photon emission. 3226 81