Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0282612 (PIN)
 2,291 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross. These vegetables are an abundant source of dietary phytochemicals, including glucosinolates and their hydrolysis products such as indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM). By 2013, the total number of natural glucosinolates that have been documented is estimated to be 132. Recently, cruciferous vegetable intake has garnered great interest for its multiple health benefits such as anticancer, antiviral infections, human sex hormone regulation, and its therapeutic and preventive effects on prostate cancer and high grade prostatic intraepithelial neoplasia (HGPIN). DIM is a hydrolysis product of glucosinolates and has been used in various trials. This review is to provide an insight into the latest developments of DIM in treating or preventing both prostate cancer and HGPIN.
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PMID:Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia. 2533 5

The interest in the prostate cancer prevention is associated with high incidence and slow growth of tumor. Despite the lack of clinical guidelines for prostate cancer prevention, more and more studies are carried out dedicated to this topic. Since prostate cancer prevention requires prolonged use, the substances derived from food are seems to be the most appropriate. The two most well-known and studied substances are indole-3-carbinol (I3C), obtained from cruciferous plants, and epigallocatechin-3-gallate (EGCG), contained in green tea. As a source of I3C and EGCG, it is possible to use a dietary supplement ProstaDoz. It also included an extract of fruits of dwarf palm, vitamin E, zinc, selenium. ProstaDoz has virtually no contraindications, has no toxic influence, even with prolonged use, does not cause adverse events and can be considered as a promising preventive and therapeutic agent for prostate cancer and prostatic intraepithelial neoplasia (PIN).
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PMID:[Prostate cancer prevention. the current trends]. 3074 97