Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0282612 (
PIN
)
2,291
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Polar transport of the phytohormone auxin controls numerous growth responses in plants. Molecular characterization of auxin transport in Arabidopsis thaliana has provided important insights into the mechanisms underlying the regulation of auxin distribution. In particular, the control of subcellular localization and expression of
PIN
-type auxin efflux components appears to be fundamental for orchestrated distribution of the growth regulator throughout the entire plant body. Here we describe the identification of two Arabidopsis loci, MOP2 and
MOP3
(for MODULATOR OF
PIN
), that are involved in control of the steady-state levels of
PIN
protein. Mutations in both loci result in defects in auxin distribution and polar auxin transport, and cause phenotypes consistent with a reduction of
PIN
protein levels. Genetic interaction between PIN2 and both MOP loci is suggestive of functional cross-talk, which is further substantiated by findings demonstrating that ectopic
PIN
up-regulation is compensated in the mop background. Thus, in addition to pathways that control
PIN
localization and transcription, MOP2 and
MOP3
appear to be involved in fine-tuning of auxin distribution via post-transcriptional regulation of
PIN
expression.
...
PMID:MODULATOR OF PIN genes control steady-state levels of Arabidopsis PIN proteins. 1765 72
