Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0282612 (
PIN
)
2,291
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The class A macrophage scavenger receptor (
SR-A
) is expressed in antigen presenting cells and is involved in host immune responses. Germ-line mutation of this gene has been associated with increased risk of human prostate cancer. However, there is little known about its expression in normal or neoplastic human prostate tissues. Double immunofluorescent labeling with monoclonal antibodies to
SR-A
and specific macrophage and dendritic cell markers was used to identify cells expressing
SR-A
in human prostate tissues.
SR-A
immunohistochemical staining was performed on paraffin sections of normal prostate,
prostatic intraepithelial neoplasia
(
PIN
) lesions, and prostate cancers from radical prostatectomy specimens.
SR-A
was expressed in a subset of macrophages and dendritic cells that infiltrated prostatic tissues. The majority of
SR-A
-positive cells coexpressed CD68, and a relatively low percentage expressed S100 protein. The number of
SR-A
-positive cells was significantly increased in
PIN
as compared with normal prostatic tissue (P = 0.0176). In contrast, the number of
SR-A
-positive cells decreased with tumor progression. A lower
SR-A
-positive cell density was associated with higher clinical stage (rho = -0.26; P = 0.0234). Inverse associations were also found between
SR-A
density and positive lymph nodes (rho = -0.23; P = 0.0437), tumor size (rho = -0.31; P = 0.0100) and preoperative PSA levels (rho = -0.32; P = 0.0057).
SR-A
density is a significant predictor of disease-free survival after surgery univariately (P = 0.0003), as well as multivariately, adjusted for known clinical and pathological markers including preoperative prostate-specific antigen, clinical stage, Gleason score, surgical margin, extraprostatic extension, and seminal vesicle invasion, as well as lymph node metastasis (P = 0.0021). The preferential accumulation of
SR-A
-positive cells in
PIN
suggests a role for
SR-A
in the APC response to early malignancy. A reduction in the number of
SR-A
-positive cells demarcates tumor progression as indicated by clinical and pathological correlations. Our results additionally indicate that systematic measurement of
SR-A
density is a strong prognostic marker for clinical outcome after surgery.
...
PMID:Reduced infiltration of class A scavenger receptor positive antigen-presenting cells is associated with prostate cancer progression. 1502 46
Prostatitis and prostate carcinoma are both frequent entities of prostatic diseases. Epidemiological studies show significant associations between infection and inflammation and prostatic carcinoma. However, because of various confounding factors the results of these studies are inconclusive. Further findings are therefore needed to confirm the hypothesis that prostatic infection and inflammation might be a cause of prostatic carcinoma. We reviewed selected reports on the role of inflammation and infection in the pathogenesis of prostate carcinoma. Extensive genetic analyses show that several gene products, e.g. 2'-5'-oligoadenylate (2-5 A)-dependent Rnase,
macrophage scavenger receptor 1
and Toll-like receptor-4, influence the susceptibility of prostate cells to infectious agents. Proliferative inflammatory atrophy (PIA) could be a connection between prostatitis and prostatic carcinoma. In the transition from PIA to
prostatic intraepithelial neoplasia
, the function of cellular detoxification is gradually lost by silencing of glutathione-S transferase, a detoxifying enzyme. This cellular feature leads to an increased susceptibility of the prostatic epithelial cells to genomic damage by inflammatory oxidants or nutritional carcinogens. Consecutive somatic genome damage might then arise which modulates the further pathogenesis of prostate carcinoma. Summarising these epidemiological, genetic and cell biological aspects, infectious prostatitis might have a causative role in the complex and multifactorial process of prostate carcinogenesis.
...
PMID:The role of inflammation and infection in the pathogenesis of prostate carcinoma. 1766 75
