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Query: UMLS:C0281663 (pregnancy and breast cancer)
 25 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Breast cancer in women under 30 years old carries a poor prognosis, for reasons that have not been identified. This study aimed to identify prognostic factors in this age group. Special attention was paid to the history of pregnancy. The clinical presentation and course of breast cancer was documented for 407 women, aged 20-29 years, who registered between 1978 and 1988 at one of nine cancer centres. Eligible patients had histologically confirmed local or regional invasive breast carcinoma, and received part or all of their initial therapy at the participating hospital. For patients whose breast cancers were diagnosed during pregnancy, the risk of dying from breast cancer was significantly greater than that of women who had never been pregnant (relative risk 3.26 [95% CI 1.81-5.87], p = 0.0004). Adjustment for number of axillary nodes affected and tumour diameter reduced the relative risk only slightly (2.83 [1.24-6.45], p = 0.023). For each 1-year increment in the time between the latest previous pregnancy and breast cancer diagnosis, the risk of dying decreased by 15% (relative risk 0.85, p = 0.011). Thus concurrent or recent previous pregnancy adversely affects survival of breast cancer in young women. The size of the effect is such that it probably contributes substantially to the poor prognosis of breast cancer in this age group as a whole.
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PMID:Effect of pregnancy on prognosis for young women with breast cancer. 1100 70

This review presents guidelines for diagnosis, staging and management of breast cancer and pregnancy in order to help update the physician in making informed decisions. A number of controversies about the management of breast carcinoma and pregnancy produces uncertainties for treating physicians and their patients and the published advice on its management is somewhat conflicting. The various modalities used for screening diagnosis and staging of breast cancer, as well as therapy, are not always applicable during pregnancy. The main goal of this article is to offer to the pregnant woman diagnosed with breast cancer the optimal therapeutic modalities, while protecting the unborn fetus of immediate and late deleterious effects of radiation and chemotherapy. The management of both breast cancer and concurrent and subsequent pregnancy in an attempt to update the treating physicians in making informed decisions in diagnosis and therapy are reviewed. Suggested guidelines for diagnosis, staging and management of breast cancer and pregnancy, according to stages of the disease and gestational stages are outlined. They are based on the understanding of current literature and our clinical and research experience in the diagnosis and therapy of breast cancer and pregnancy.
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PMID:Breast cancer and related pregnancy: suggested management according to stages of the disease and gestational stages. 1293 4

The results of 14 cases of breast cancer and pregnancy observed in 1261 breast carcinoma, diagnosed and in treatment between January 1980 and March 2001 were analysed. The results were compared with 122 cases of not pregnant patients with similar ages (< or = 40). The pregnant patients had a medium following of 58.6 months and controls of 73.9 months. Otherwise the results are not significant; it shows a higher incidence of disseminate carcinomas diagnose in the pregnant patients (14.3% vs. 4.9%), a higher recidives (50% vs. 37.4%) and a higher mortality (50% vs. 30.3).
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PMID:[Breast cancer and pregnancy. Analysis of our casuistry and literature review]. 1461 92