Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0279530 (bone cancer)
 1,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
osteosarcoma 259
Sep 71
Mol 71
Walker 51
p53 28
opioid receptor 22
TNF 21
caspase-3 20
ERK 19
glial fibrillary acidic protein 19
PI3K 18
collagen 17
IL-6 16
cytokine 15
AKT 15
RANKL 14
osteogenic 14
chemokine 13
NR2B 13
alkaline phosphatase 12
nerve growth factor 12
Bcl-2 12
catenin 11
p38 11
tumor necrosis factor 10
histone 10
HOS 10
MRI 10
EWS 10
calcitonin 10
FLI1 9
ACS 9
matrix metalloproteinase 9
MMP-9 8
RANK 8
DRG 7
TLR4 7
osteoprotegerin 7
ERK1 7
P2X7 7
extracellular signal-regulated kinase 7
cage 6
substance P 6
c-Jun 6
UTR 6
CGRP 6
MMP2 6
cytochrome c 6
TRPV1 6
MMP9 6
vascular endothelial growth factor 6
PARP 6
CCR2 6
p21 6
dynorphin 6
MEK 6
transient receptor potential vanilloid 1 6
ATP 6
rhabdomyosarcoma 6
CXCR3 5
CXCL12 5
MAPK 5
MMP-2 5
P2X3 5
mTOR 5
PKA 5
CX3CR1 5
NMDA receptor 5
pRb 5
CB2 5
IL-1 5
PBS 5
SNS 5
PKC 5
p38 mitogen-activated protein kinase 4
IL-18 4
c-Src 4
PD-1 4
non-Hodgkin's lymphoma 4
RUNX2 4
insulin 4
hole 4
caspase-9 4
CD99 4
annexin V 4
CXCL1 4
Li-Fraumeni syndrome 4
JNK 4
endoplasmic reticulum 4
caspase-8 4
CCL2 4
IL-10 4
COX-2 4
epidermal growth factor receptor 4
fused 4
serum albumin 4
protein kinase B 4
EphB2 4
proteasome 4
Nanog 4
XIAP 4
tropomyosin 3
HMGB1 3
EphB1 3
STAT3 3
CaMKII 3
WIN 3
CD133 3
RANTES) 3
Mcl-1 3
membrane-bound 3
phosphatidylinositol 3-kinase 3
C18 3
fractalkine 3
EWSR1 3
insulin-like growth factor 3
glycoprotein 3
Ki-67 3
lipopolysaccharide 3
estrogen receptor 3
OPG 3
Bak 3
VEGF 3
IL-17 3
signal transducer and activator of transcription 3 3
member 1 3
LPS 3
CXCL10 3
cannabinoid receptor 3
proenkephalin 3
RhoA 3
E2F1 3
histone deacetylase 3
ubiquitin 3
NR1 3
receptor kinase 3
Rho 3
Smad3 3
LC3 3
metabotropic glutamate receptor 3
sirtuin 1 3
c-Myc 3
CD4 3
parathyroid hormone 3
CXCR4 3
tartrate-resistant acid phosphatase 3
membrane protein 3
bone morphogenetic protein 3
RANTES 3
tumor necrosis factor alpha 3
threonine 3
CREB 2
ATR 2
transmembrane receptor 2
high mobility group box 1 2
kinesin 2
JAMA 2
PTD 2
sodium channel 2
E-cadherin 2
TCP 2
monocyte chemoattractant protein-1 2
P-glycoprotein 2
MMP 2
Apaf-1 2
Runt-related transcription factor 2 2
GTPase 2
T-cell death-associated gene 8 2
proteasome inhibitor 2
PD-L1 2
platelet-derived growth factor 2
Cx43 2
phosphoinositide 3-kinase 2
GDNF 2
GABA 2
TRPA1 2
MMP7 2
P2X2 2
IAP 2
osteocalcin 2
vimentin 2
lectin 2
CAR 2
Fas 2
RASSF2 2
transcriptional repressor 2
NAC 2
collagenase-3 2
tyrosine kinase 2
KCC2 2
ATM 2
calpain 2
NMR 2
calcium/calmodulin-dependent protein kinase II 2
ROS 2
C30 2
IL-8 2
mGluR5 2
BMP2 2
methyltransferase 2
macrophage colony-stimulating factor 2
CC chemokine 2
CXCR2 2
MDP 2
cAMP-response element 2
connexin 2
glial cell line-derived neurotrophic factor 2
FDG 2
KIF17 2
IGF-1 2
SIRT1 2
CDL 2
CTNNB1 2
HDAC1 2
nuclear receptor 2
mouse) 2
phosphatase and tensin homolog 2
receptor tyrosine kinase 2
IL-33 2
Fli-1 2
Sp1 2
GM-CSF 2
cytochrome 2
STAT 2
MET 2
dynamin-related protein 1 2
G-CSF 2
RNA-binding protein 2
Pigment epithelium-derived factor 2
FLI 2
CB1 2
cyclin-dependent kinase 2
pro-apoptotic protein 2
neurotrophic factor 2
interferon 2
CFA 2
p65 2
TEM 2
ECM 2
epidermal growth factor 2
interleukin-6 2
intercellular adhesion molecule-1 2
bone) 2
p27 2
chronic renal failure 2
connexin 43 2
PTEN 2
NGF 2
histone H3 2
endonuclease G 2
AIF 2
NaN 2
YAP 2
CD44 2
TGA 2
Osteocalcin 2
JNK1 2
GTP 2
Histone deacetylase 2
MT1-MMP 2
calmodulin 2
granulocyte 2
BAX 2
LPA1 2
RAD51 2
SP1 2
ERG 2
mu opioid receptor 2
Wnt inhibitory factor-1 2
G-protein-coupled receptor 2
CD147 2
She 2
ataxia telangiectasia mutated 2
neuronal nitric oxide synthase 2
cadherin 2
glutamate receptor 2
F10 1
ROCK2 1
protease-activated receptor 4 1
lysyl oxidase 1
DMS 1
TNT 1
IL1B 1
CC-chemokine 1
fatty acid amide hydrolase 1
RASSF10 1
cIAP1 1
Smac 1
artemin 1
TGFB1 1
TIMP3 1
HMGB3 1
kallikrein 1
endocytic receptor 1
Plasmin 1
endothelin receptor 1
PTK 1
microtubule-associated protein 1
PDB 1
cyclin E 1
OFQ 1
protein X 1
MMP13 1
hedgehog 1
Ang II 1
C-C 1
CBT 1
Hua 1
GLUT1 1
CASP9 1
Iba1 1
SRY 1
sodium-potassium-chloride cotransporter 1
LMNA protein 1
EZH2 1
VIM 1
bradykinin 1
KCNQ3 1
c-fos 1
4E-BP1 1
more...
Disease
bone cancer 1036
cancer 496
tumor 357
osteosarcoma 327
Osteosarcoma 207
Osteosarcoma 207
metastases 113
carcinoma 63
tumor growth 59
breast cancer 58
chronic pain 52
Ewing's sarcoma 49
sarcoma 49
bone metastases 47
osteoporosis 41
leukemia 34
lung cancer 34
prostate cancer 32
chondrosarcoma 31
primary tumor 22
Chondrosarcoma 21
Chondrosarcoma 21
tumor progression 19
tumorigenesis 17
melanoma 16
osteoarthritis 16
bone disease 15
chordoma 15
fibrosarcoma 15
Frey 15
multiple myeloma 13
rheumatoid arthritis 13
retinoblastoma 13
PDB 11
HOS 10
metastatic osteosarcoma 10
arthritis 10
Sarcoma 10
childhood cancer 10
Sarcoma 10
carcinogenesis 9
liver cancer 9
thyroid cancer 9
cold 8
lung metastases 8
liver cancer 8
gastric cancer 8
Hodgkin's disease 8
skin cancer 7
renal cancer 7
rhabdomyosarcoma 7
rare disease 7
neuropathy 7
cervical cancer 7
anemia 7
thrombocytopenia 6
lymphoma 6
colorectal cancer 6
aggressiveness 6
neuroblastoma 6
Blocking 6
brain cancer 6
Li-Fraumeni syndrome 6
osteolytic sarcoma 5
SEM 5
osteomyelitis 5
herpes simplex 5
acute myeloid leukemia 5
colon cancer 5
cutaneous melanoma 5
pancreatic cancer 5
B-cell lymphoma 4
MCF 4
periodontitis 4
non-Hodgkin's lymphoma 4
periosteum 4
peripheral neuropathy 4
squamous cell carcinoma 4
solid tumor 4
metastatic breast cancer 4
hypercalcemia 4
ovarian cancer 4
diabetic neuropathy 4
suicide 4
bladder cancer 4
leukopenia 4
cirrhosis 3
dysphagia 3
dysplasia 3
otitis externa 3
esophageal cancer 3
tumor angiogenesis 3
tumor initiation 3
endometrial cancer 3
second cancer 3
tuberculosis 3
lymphosarcoma 3
chondroblastic osteosarcoma 3
pathological fracture 3
rectal cancer 3
neuroma 3
sickle cell disease 3
middle ear 3
esophageal cancer 3
hypercalcemia of malignancy 3
connective tissue cancer 3
chronic lymphocytic leukemia 3
WT1 3
neutropenia 3
residual disease 3
uterine cancer 2
carcinomatosis 2
osteomalacia 2
physical dependence 2
hepatocellular carcinoma 2
ATM 2
chronic lymphocytic leukemia 2
bronchogenic carcinoma 2
silicosis 2
uterus 2
TCP 2
cardiovascular disease 2
dementia 2
disseminated intravascular coagulation 2
hematologic malignancies 2
vagina 2
Alzheimer's disease 2
Lip 2
disinhibition 2
PTD 2
pulmonary tuberculosis 2
myelodysplastic syndrome 2
Cornelia de Lange syndrome 2
myelosuppression 2
osteoma 2
fits 2
osteopetrosis 2
adenocarcinoma 2
asbestosis 2
hepatitis 2
aggression 2
depression 2
aplastic anemia 2
otitis media 2
adenoma 2
periodontal disease 2
oral cancer 2
lung carcinoma 2
NAME 2
incontinence 2
TEM 2
chronic renal failure 2
acute nonlymphocytic leukemia 2
TEM 2
chronic myeloid leukemia 2
bone neoplasm 2
bacterial infection 2
confusion 2
SCID 2
Thyroid cancer 2
epiphysis 2
malignant fibrous histiocytoma 2
diabetes 2
type 2 diabetes 1
sepsis 1
familial cancer 1
osteochondroma 1
SCH 1
chronic disease 1
uterine corpus cancer 1
recurrent osteosarcoma 1
Still 1
synovial sarcoma 1
lipoma 1
osteoporotic fracture 1
Bladder 1
ash 1
emphysema 1
pulmonary fibrosis 1
mole 1
pericoronitis 1
immunodeficiency 1
pulpitis 1
hepatic encephalopathy 1
carcinoma of the breast 1
scrotum 1
leiomyoma 1
CNS cancer 1
immune disorder 1
brain abscess 1
respiratory failure 1
CTX 1
HTLV-I 1
DMS 1
Cushing's disease 1
otitis 1
asthma 1
benign tumor 1
eye cancer 1
atherosclerosis 1
signet ring cell carcinoma 1
meninges 1
ADD 1
plasmacytoma 1
spindle cell sarcoma 1
autism 1
sensory neuropathy 1
PML 1
histoplasmosis 1
mastoiditis 1
erysipelas 1
Giant cell tumor 1
acute lymphoblastic leukemia 1
infectious diseases 1
non-small cell lung cancer 1
mole 1
renal cell carcinoma 1
silicotuberculosis 1
pelvic inflammatory disease 1
Fanconi 1
malignant mesothelioma 1
transitional cell carcinoma 1
hypertension 1
carcinosarcoma 1
SPM 1
schizoaffective disorder 1
multicore 1
Larynx 1
metastatic pancreatic cancer 1
liposarcoma 1
PBD 1
Bradley 1
parkinsonism 1
melanosis 1
glioblastoma 1
schizophrenia 1
glioma 1
chronic pancreatitis 1
coxsackievirus 1
Nasopharyngeal carcinoma 1
CAM 1
skin hypersensitivity 1
ABS 1
Pycnodysostosis 1
catalepsy 1
radiation carcinogenesis 1
addiction 1
hyperthyroidism 1
RTS 1
NF2 1
Leukemia 1
Pineal 1
Larynx 1
hyperostosis 1
Giant cell tumor of bone 1
Larynx 1
Poland 1
optic atrophy 1
Dedifferentiated chordoma 1
myocardial infarction 1
osteogenesis imperfecta 1
iron overload 1
SARS 1
public drinking 1
SDS 1
celiac disease 1
Fibrosarcoma 1
Malignant neoplasms 1
Rhabdomyosarcoma 1
CNS diseases 1
Larynx 1
embryonal rhabdomyosarcoma 1
sepsis 1
SAR 1
CCD 1
AS1 1
OSX 1
histiocytic lymphoma 1
primary hyperparathyroidism 1
Bone marrow depression 1
bone marrow cancer 1
amyotrophic lateral sclerosis 1
regional pain syndrome 1
Ewing's sarcoma of bone 1
HCG 1
spinal cord compression 1
obstructive jaundice 1
BLM 1
Fox 1
head and neck cancer 1
primitive neuroectodermal tumor 1
DBA 1
arthropathy 1
ankylosing spondylitis 1
Desmoplastic small round cell tumor 1
Prostate Cancer 1
scoliosis 1
APC 1
cystitis 1
Turner syndrome 1
RAEB 1
obesity 1
dermatitis 1
hormone refractory prostate cancer 1
ear infection 1
osteoblastic osteosarcoma 1
Bladder 1
Bladder 1
WRN 1
HGF 1
enchondroma 1
ABS 1
telangiectatic osteosarcoma 1
Infection 1
pheochromocytoma 1
Giant cell sarcoma 1
Plaque 1
facial palsy 1
residual cancer 1
hypopituitarism 1
more...
Symptom
pain 353
cancer pain 83
bone pain 61
analgesia 35
headache 5
discomfort 4
discomfort 4
breakthrough pain 3
low back pain 3
myalgia 2
nausea 2
fatigue 2
arthralgia 2
anesthesia 2
back pain 2
anorexia 2
constipation 2
otalgia 2
chronic cough 1
paresis 1
nausea and vomiting 1
Other pain 1
prominent nose 1
neuralgia 1
insomnia 1
chest pain 1
No pain 1
skin pain 1
torticollis 1
acute pain 1
Neuropathic pain 1
agitation 1
dry skin 1
Severe pain 1
collapse 1
Flare 1
Metastatic bone pain 1
physical symptom 1
dental pain 1
Drug
Monit 5
EHDP 5
lysine 5
Zoledronic acid 4
Zoledronic acid 3
GEO 3
CSF 3
G-CSF 2
ETS 2
Gelatin 2
citric acid 2
Cetuximab 2
ROS 2
Denosumab 2
CTX 1
Adriamycin 1
Teriparatide 1
APD 1
RAL 1
Rubitecan 1
Anakinra 1
Silica 1
Honey 1
Lumiracoxib 1
Capsicum 1
FAD 1
CAM 1
ZnO 1
PTH 1
Propentofylline 1
Gel 1
ADM 1
Epigallocatechin 1
TAK 1
Cilengitide 1
Barium sulfate 1
p75 1
TTC 1
PDL 1
Imatinib 1
Iguratimod 1
CTX 1
Exenatide 1
Celebrex 1
Simvastatin 1
ROC 1
NVP 1
IL-1ra 1
CTX 1
Cardiovasc 1
Enzyme
mitogen-activated protein kinase 28
ERK 27
protein kinase 19
caspase-3 15
luciferase 14
alkaline phosphatase 12
protein kinase C 12
ACS 9
PARP 7
MEK 6
caspase-8 4
proteasome 4
focal adhesion kinase 4
caspase-9 3
phosphatidylinositol 3-kinase 3
cytosine deaminase 3
NOS 2
P-glycoprotein 2
MMP 2
CaMKII 2
AMP-activated protein kinase 2
phosphoinositide 3-kinase 2
kinesin 2
MDP 2
AMPK 1
PKG 1
nicotinamide phosphoribosyltransferase 1
prostate-specific antigen 1
caspase-7 1
phosphatidylinositol-4,5-bisphosphate 3-kinase 1
ATPase 1
lactate dehydrogenase 1
DSR 1
topoisomerase 1
tyrosine hydroxylase 1
serine hydroxymethyltransferase 1
GRK5 1
trypsin 1
topoisomerase 1
phosphodiesterase 1
PDK1 1
acid phosphatase 1
prostate-specific membrane antigen 1
collagenase 1
polo-like kinase 1 1
APC 1
sphingosine kinase 1
GSK 1
AMPK 1
thymidine kinase 1
superoxide dismutase 1
carboxypeptidase E 1
caspase-7 1
NO synthase 1
KLK7 1
thymidylate synthase 1
reverse transcriptase 1
deaminase 1
lysyl oxidase 1
catalase 1
methylthioadenosine phosphorylase 1
RNA polymerase 1
kallikrein 1
Compound
Dec 74
Clin 38
DNA 33
calcium 28
oxygen 25
TNF 21
water 18
MTT 17
phosphate 16
iron 12
selenium 11
ACS 9
Adriamycin 9
titanium 9
glutamate 9
ACS 9
nitrogen 8
Morphine 8
silver 8
ADR 8
sodium 7
cAMP 6
MEK 6
strontium 6
ATP 6
Curcumin 6
DTPA 5
lysine 5
glucose 5
potassium 5
hydrogen 5
EHDP 5
APAP 4
methionine 4
CaO 4
aspartic acid 4
Asp 4
threonine 4
aspartic acid 4
vitamin D 4
NH2 4
zinc 4
aspartic acid 4
bromide 4
aspartic acid 4
salt 4
iodine 3
ASA 3
acetic acid 3
serine 3
MDA 3
alanine 3
MK801 3
vanadium 3
Resveratrol 3
DMSO 3
Oxycodone 3
dUTP 3
tyrosine 3
Pac 3
nitrate 3
MNNG 3
2-hydroxyethyl 2
Lactate 2
ADP-ribose 2
GABA 2
propionic acid 2
Naringin 2
Cyt 2
Chitosan 2
2-hydroxyethyl 2
TCP 2
2-hydroxyethyl 2
tin 2
PPI 2
copper 2
2-hydroxyethyl 2
arginine 2
TCP 2
2-hydroxyethyl 2
NCD 2
2-hydroxyethyl 2
GTP 2
carbonate 2
2,4-dichlorophenyl 2
NAD 2
Bufalin 2
TEM 2
Melatonin 2
2-hydroxyethyl 2
DAMGO 2
5-FU 2
DDP 2
formaldehyde 2
2,4-dichlorophenyl 2
retinoic acid 2
Naringin 2
Panam 2
Etanercept 2
propionic acid 2
PEG 2
isoquinoline 2
N-acetylcysteine 2
His 2
Hoechst 33342 2
TCP 2
2-hydroxyethyl 2
Naloxone 2
Gelsemine 2
cysteine 2
NMDA 2
Lip 2
GABA 2
TCP 2
sulfate 2
Phe 1
Ursolic acid 1
kaempferol 1
Catechol 1
Triptolide 1
proline 1
adenosylmethionine 1
1H-indole 1
Sphingosine 1-phosphate 1
Phosphatidylinositol 1
Dithiothreitol 1
Wogonin 1
nickel 1
PTSM 1
Primatol 1
Tomatidine 1
Histone 1
glutamine 1
Tetrahydropalmatine 1
1H-pyrazole 1
Diclofenac 1
1H-imidazole 1
ammonium 1
SPM 1
A 3 1
rubidium 1
PMA 1
Glutaraldehyde 1
Tramadol 1
Oxytocin 1
PID 1
Sialic acid 1
Primatol 1
IBA 1
TNM 1
boric acid 1
propionamide 1
Gly 1
Topotecan 1
Primatol 1
Tris 1
5-HT 1
benzamide 1
Gemcitabine 1
DTT 1
Berberine 1
Capsaicin 1
Alendronate 1
chalcone 1
CCP 1
1,2-ethanediamine 1
1,2-ethanediamine 1
Thymidine 1
IBA 1
Iodo 1
Cbl 1
CPA 1
ethanol 1
Glutamate 1
DHPG 1
AMPA 1
Neurotensin 1
SDS 1
5-Aza-2'-deoxycytidine 1
Dithiothreitol 1
CPP 1
PGE2 1
Triton 1
BAP 1
boron 1
Titanium dioxide 1
Metformin 1
Epigallocatechin 1
Tris 1
phosphorus 1
pentosidine 1
CPP 1
FAD 1
Radon-222 1
CHNO 1
ATF 1
Tamoxifen 1
Tanshinone 1
iodobenzene 1
nitric oxide 1
Epigallocatechin gallate 1
Allyl isothiocyanate 1
leucine 1
Ang II 1
DPPH 1
Risedronate 1
acetonitrile 1
BMC 1
SET 1
Rapamycin 1
Metformin 1
MSM 1
1H-pyrazole 1
propionamide 1
Lycorine 1
Bismuth 1
vinyl 1
Morin 1
AEA 1
cyclohexane 1
methane 1
Vancomycin 1
tetraethyl orthosilicate 1
PMA 1
acetate 1
Dezocine 1
Amide 1
Mg2+ 1
Minocycline 1
PEG 1
Gemcitabine 1
Neuronal 1
NAD 1
[1,2,4]triazolo[4,3-a]pyrimidine 1
acridine 1
Cyanate 1
Lappaconitine 1
ALP 1
Tricalcium phosphate 1
5-methylisoxazole 1
Daunomycin 1
Daunorubicin 1
Topotecan 1
CTP 1
Loperamide 1
APTES 1
Clofazimine 1
Alendronate 1
Alizarin 1
Hematoxylin 1
PEI 1
noradrenaline 1
Trypsin 1
HAP 1
benzophenone 1
MPE 1
formaldehyde 1
pyrrolidine 1
Neo 1
Tomatidine 1
Vitamin D 1
ACTH 1
benzo[c]phenanthridine 1
Cycloheximide 1
CTX 1
PBD 1
PID 1
pyrrolidine 1
PEI 1
DTT 1
Resiniferatoxin 1
TMA 1
Substance P 1
isoxazole 1
aluminum 1
APT 1
cGMP 1
Alantolactone 1
Spironolactone 1
1,3-dihydro-2H-benzimidazol-2-one 1
Pluronic 1
Brilliant Blue 1
silicon 1
N-Hydroxysuccinimide 1
CAM 1
Paeonol 1
Pimozide 1
Abbott 1
DMS 1
4-methylphenyl 1
Wellcome 1
1H-imidazole 1
4-AP 1
Neu5Ac 1
CHNO 1
Insulin 1
Tamoxifen 1
fluorine 1