Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0279530 (bone cancer)
 1,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ERG/EWS 14.9
C3orf35 13.9
LMNA protein 12.9
brachyury protein 12.3
ECHDC2 12.3
Neurensin-2 12.1
TSGA14 12.1
TUT1 11.7
T-cell death-associated gene 8 11.2
SUV420H2 11.2
antioxidant protein 1 11.1
SCN7A 11.0
DNAJA4 11.0
bone-derived growth factor 11.0
TRIM46 10.7
PHF11 10.7
CLL1 10.4
C-X-C chemokine receptor type 5 10.4
KPNA3 10.4
ROCK2 protein 10.4
Visinin-like protein 1 10.3
MMP28 10.3
DIF-3 10.2
EDG2 10.1
EPB41 10.1
Calpain-2 10.1
MTBP 10.1
TEAD2 10.1
RASSF10 10.0
RARRES2 9.9
SKA2 9.9
KIF17 9.8
MRC2 9.8
RASSF2 9.7
Stathmin 1 9.7
claspin 9.6
CDL 9.5
HMGB3 9.5
EphB1 9.5
NPTX2 9.4
CTNND1 9.4
sodium-potassium-chloride cotransporter 9.4
NSD3 9.3
UBF1 9.3
MAPK7 9.3
FGF12 9.3
NET-1 9.3
UEV1A 9.2
MRTF-B 9.2
LPCAT2 9.2
PPP1R15A 9.2
peroxiredoxin 4 9.1
osteosarcoma 9.1
NGD 9.1
SHMT2 9.0
stem cell growth factor 9.0
Protease-activated receptor 2 9.0
NOT1 9.0
MLK2 9.0
Suppressor of cytokine signaling 3 8.9
Annexin A3 8.9
claudin-8 8.9
Voltage-dependent anion channel 8.8
TCRD 8.8
FLI1 8.7
cytosolic phosphoprotein 8.7
CTHRC1 8.6
MEPE 8.6
ribosomal S6 protein kinase 8.6
E2 antigen 8.6
HOS 8.5
RAB5 8.4
TNAP 8.4
tankyrase 2 8.4
KLK7 8.4
SLC1A1 8.4
XLMR 8.4
SHMT1 8.3
zinc finger E-box binding homeobox 1 8.3
Calcium/calmodulin-dependent protein kinase II 8.3
protease-activated receptor 4 8.3
GTF2I 8.3
SIGIRR 8.2
EWS 8.2
secreted frizzled-related protein 1 8.2
EphB2 8.2
HOXB7 8.1
KID 8.1
Walker 8.1
Forkhead box M1 8.1
excision repair protein 8.1
mitofusin 1 8.0
FOXF1 8.0
BMP1 8.0
MTAP 8.0
Pigment epithelium-derived factor 8.0
R-cadherin 8.0
Kv3.4 7.9
HMGB2 7.9
BUB1B 7.9
PTH1 7.9
P2X3 7.8
RPA1 7.8
SP7 7.8
DSR 7.8
CHEK1 7.8
glutamate carboxypeptidase II 7.8
SPS1 7.8
Wnt inhibitory factor-1 7.7
pycnodysostosis 7.7
ATG3 7.7
extracellular signal-regulated kinase 5 7.7
LPA1 7.7
secreted phosphoprotein 1 7.7
hephaestin 7.7
DNA ligase III 7.7
KIT protein 7.6
SOX5 7.6
FLI 7.6
methylthioadenosine phosphorylase 7.6
Li-Fraumeni syndrome 7.6
P2RX7 7.5
FIP200 7.5
parathyroid hormone receptor 7.5
SNS 7.5
OSX 7.4
Runt-related transcription factor 2 7.4
OMG 7.4
Transforming growth factor-alpha 7.3
KIP 7.3
tissue inhibitor of metalloproteinase-3 7.3
tissue inhibitor of metalloproteinases-2 7.3
endonuclease G 7.3
Ras-related protein 7.3
IGFBP1 7.2
collagenase-3 7.2
NR2B 7.2
proteinase-activated receptor-2 7.1
preprodynorphin 7.1
EWSR1 7.1
RASSF1 7.1
receptor protein tyrosine kinase 7.1
CASP9 7.1
RAMP1 7.1
insulin-like growth factor binding protein-4 7.1
PEDF 7.1
Janus kinase 1 7.1
TUBB3 7.1
CX3CR1 7.0
Ubc13 7.0
SETD2 7.0
artemin 7.0
HSP70-1 7.0
CSN5 7.0
Fli-1 6.9
mGluR3 6.9
MMP7 6.9
E2F2 6.9
KCNQ3 6.9
CC-chemokine 6.9
more...
Disease
bone cancer 14.9
osteolytic sarcoma 14.2
Giant cell sarcoma 13.9
connective tissue cancer 13.0
Dedifferentiated chordoma 12.3
Osteosarcoma 11.5
Osteosarcoma 11.5
Chondrosarcoma 10.5
Chondrosarcoma 10.5
bone marrow cancer 10.4
Pediatric Tumor 10.2
metastatic osteosarcoma 9.8
chondroblastic osteosarcoma 9.7
recurrent osteosarcoma 9.4
osteosarcoma 9.2
uterine corpus cancer 9.0
Bone marrow depression 8.8
silicotuberculosis 8.7
Ewing's sarcoma of bone 8.7
telangiectatic osteosarcoma 8.5
Pycnodysostosis 8.4
Ewing's sarcoma 8.3
HOS 8.1
bone neoplasm 8.1
chordoma 8.1
eye cancer 8.0
bone metastases 7.8
Postoperative infection 7.8
chondrosarcoma 7.8
hypercalcemia of malignancy 7.7
pericoronitis 7.6
Li-Fraumeni syndrome 7.5
Fibrosarcoma 7.5
Frey 7.5
Sarcoma 7.4
Sarcoma 7.4
public drinking 7.3
Malignant neoplasms 7.2
osteoblastic osteosarcoma 7.2
ear infection 6.9
radiation carcinogenesis 6.9
Cornelia de Lange syndrome 6.9
CNS cancer 6.8
second cancer 6.7
Giant cell tumor of bone 6.7
PTD 6.7
Desmoplastic small round cell tumor 6.6
hormone refractory prostate cancer 6.6
PBD 6.5
brain cancer 6.4
otitis externa 6.4
OSX 6.4
spindle cell sarcoma 6.4
chronic pain 6.4
enchondroma 6.3
skin hypersensitivity 6.2
childhood cancer 6.2
Lip 6.1
MPE 6.1
Giant cell tumor 6.0
fibrosarcoma 6.0
bone disease 6.0
metastatic pancreatic cancer 5.9
ADD 5.9
uterine cancer 5.9
neuroma 5.9
signet ring cell carcinoma 5.9
immune disorder 5.9
sarcoma 5.9
lymphosarcoma 5.8
pathological fracture 5.8
multicore 5.7
Bradley 5.7
PDB 5.6
pulpitis 5.6
asbestosis 5.6
Thyroid cancer 5.6
RAEB 5.5
lung metastases 5.5
renal cancer 5.4
acute nonlymphocytic leukemia 5.4
mastoiditis 5.4
cutaneous melanoma 5.4
residual cancer 5.3
RTS 5.3
osteopetrosis 5.3
familial cancer 5.3
embryonal rhabdomyosarcoma 5.2
physical dependence 5.2
retinoblastoma 5.2
rhabdomyosarcoma 5.1
ABS 5.1
diabetic neuropathy 5.1
silicosis 5.1
primary tumor 5.1
metastases 5.1
erysipelas 5.1
osteoporosis 5.0
thyroid cancer 5.0
ABS 5.0
Rhabdomyosarcoma 5.0
musculoskeletal disease 5.0
melanosis 5.0
periosteum 5.0
DMS 4.9
tumor growth 4.9
osteoma 4.9
regional pain syndrome 4.8
SPM 4.8
tumor initiation 4.7
osteochondroma 4.6
malignant fibrous histiocytoma 4.6
renal osteodystrophy 4.5
osteoporotic fracture 4.5
histiocytic lymphoma 4.4
liver cancer 4.4
Fox 4.4
carcinomatosis 4.4
renal cyst 4.4
Blocking 4.3
osteomalacia 4.3
primitive neuroectodermal tumor 4.3
chronic otitis media 4.3
otitis 4.2
liver cancer 4.2
craniopharyngioma 4.2
hyperostosis 4.2
Nasopharyngeal carcinoma 4.1
bronchogenic carcinoma 4.1
skin cancer 4.1
rare disease 4.1
sensory neuropathy 4.1
TCP 4.1
leukopenia 4.1
prostate cancer 4.1
AS1 4.0
solid tumor 4.0
tumor 4.0
epiphysis 4.0
metastatic breast cancer 4.0
brain abscess 3.9
tumor angiogenesis 3.9
carcinosarcoma 3.9
aggressiveness 3.9
synovial sarcoma 3.9
lung cancer 3.9
tumor progression 3.8
schizoaffective disorder 3.8
WRN 3.8
cancer 3.8
osteoarthritis 3.8
optic atrophy 3.8
THC 3.8
osteomyelitis 3.7
disinhibition 3.7
catalepsy 3.7
carcinoma 3.7
HTLV-I 3.7
hypopituitarism 3.6
Bladder 3.6
more...
Symptom
Metastatic bone pain 12.6
Other pain 10.2
cancer pain 9.7
bone pain 9.2
skin pain 8.7
prominent nose 8.5
No pain 8.1
breakthrough pain 7.8
Severe pain 7.6
Flare 7.4
physical symptom 7.0
otalgia 5.9
pain 5.4
analgesia 5.3
dry skin 4.9
dental pain 4.7
Neuropathic pain 4.4
torticollis 4.2
neuralgia 4.1
chronic cough 3.9
myalgia 3.2
low back pain 3.2
arthralgia 3.1
acute pain 3.0
constipation 2.6
discomfort 2.5
paresis 2.4
back pain 2.3
discomfort 2.3
anorexia 2.2
nausea and vomiting 1.7
insomnia 1.5
headache 1.5
nausea 1.4
agitation 1.3
chest pain 0.8
fatigue 0.2
collapse 0.1
anesthesia -0.8
Drug
Rubitecan 11.9
Iguratimod 10.3
Lumiracoxib 9.3
Barium sulfate 9.1
Cilengitide 8.7
Propentofylline 8.6
EHDP 8.3
Celebrex 8.0
Zoledronic acid 7.5
Zoledronic acid 7.3
Anakinra 6.9
RAL 6.9
Denosumab 6.8
Exenatide 6.6
Teriparatide 6.5
Epigallocatechin 6.1
Cetuximab 6.0
GEO 5.9
PDL 5.5
Gelatin 5.1
APD 5.1
NVP 5.0
TAK 5.0
ETS 4.5
Honey 4.5
IL-1ra 4.5
Simvastatin 4.2
TTC 4.0
Capsicum 3.8
Silica 3.7
Imatinib 3.6
G-CSF 3.5
ADM 3.3
p75 3.0
Adriamycin 2.7
citric acid 2.6
FAD 2.5
CTX 2.4
CTX 2.4
CAM 2.4
PTH 2.2
Monit 2.1
ROC 2.0
ROS 1.7
CTX 1.6
CSF 1.6
lysine 1.4
ZnO 1.2
Gel 1.0
Cardiovasc -2.7
Enzyme
DSR 8.0
KLK7 7.4
phosphatidylinositol-4,5-bisphosphate 3-kinase 7.3
methylthioadenosine phosphorylase 7.1
cytosine deaminase 6.9
nicotinamide phosphoribosyltransferase 6.4
carboxypeptidase E 6.3
serine hydroxymethyltransferase 5.7
sphingosine kinase 5.4
caspase-7 5.1
caspase-7 5.1
GRK5 4.8
lysyl oxidase 4.6
MDP 4.5
polo-like kinase 1 4.3
caspase-8 4.2
prostate-specific membrane antigen 4.1
PARP 4.0
CaMKII 3.9
MMP 3.9
PDK1 3.8
caspase-3 3.7
caspase-9 3.6
PKG 3.6
kinesin 3.6
luciferase 3.5
phosphoinositide 3-kinase 3.4
MEK 3.3
mitogen-activated protein kinase 3.2
ERK 3.1
thymidylate synthase 3.1
NOS 3.1
phosphatidylinositol 3-kinase 3.1
alkaline phosphatase 2.9
protein kinase C 2.9
protein kinase 2.8
deaminase 2.6
kallikrein 2.3
AMPK 2.3
AMP-activated protein kinase 2.2
P-glycoprotein 2.2
GSK 2.2
prostate-specific antigen 2.1
proteasome 2.1
thymidine kinase 2.0
ACS 1.8
topoisomerase 1.7
topoisomerase 1.6
focal adhesion kinase 1.5
AMPK 1.3
acid phosphatase 1.3
tyrosine hydroxylase 1.1
NO synthase 1.0
APC 0.9
collagenase 0.7
phosphodiesterase 0.7
lactate dehydrogenase 0.1
reverse transcriptase -0.0
RNA polymerase -0.2
trypsin -0.5
catalase -0.9
superoxide dismutase -0.9
ATPase -1.1
Compound
[1,2,4]triazolo[4,3-a]pyrimidine 12.6
Gelsemine 11.9
Tomatidine 10.3
Tomatidine 10.3
Lappaconitine 10.2
Dezocine 10.1
Tetrahydropalmatine 9.6
N-Hydroxysuccinimide 9.3
Radon-222 9.2
Alantolactone 9.1
PTSM 9.0
1,3-dihydro-2H-benzimidazol-2-one 8.9
Lycorine 8.8
Bufalin 8.6
EHDP 8.5
Resiniferatoxin 8.5
Oxycodone 8.5
CHNO 8.5
CHNO 8.4
Tricalcium phosphate 8.2
Cyanate 7.9
benzo[c]phenanthridine 7.9
NCD 7.8
Naringin 7.7
Paeonol 7.5
1,2-ethanediamine 7.5
Daunomycin 7.4
Risedronate 7.4
1,2-ethanediamine 7.4
Clofazimine 7.2
Wogonin 7.2
MNNG 7.0
Naringin 7.0
Allyl isothiocyanate 7.0
MPE 6.9
2,4-dichlorophenyl 6.7
2,4-dichlorophenyl 6.7
Loperamide 6.7
Etanercept 6.6
PBD 6.5
Pimozide 6.5
Ursolic acid 6.3
propionamide 6.3
Topotecan 6.3
propionamide 6.3
APT 6.2
MK801 6.2
Morin 6.2
iodobenzene 6.1
Iodo 6.1
APTES 6.1
Triptolide 5.9
Daunorubicin 5.9
Tanshinone 5.9
Sphingosine 1-phosphate 5.9
Alendronate 5.8
Topotecan 5.7
Alendronate 5.7
5-Aza-2'-deoxycytidine 5.7
pentosidine 5.6
Morphine 5.6
CaO 5.5
Dithiothreitol 5.5
Tramadol 5.5
DHPG 5.5
Brilliant Blue 5.5
DAMGO 5.5
Lip 5.5
HAP 5.4
Spironolactone 5.4
Epigallocatechin 5.3
IBA 5.3
ADR 5.3
Dithiothreitol 5.3
1H-imidazole 5.2
BAP 5.2
4-methylphenyl 5.1
strontium 5.1
IBA 5.1
tetraethyl orthosilicate 5.1
Adriamycin 5.0
Glutaraldehyde 5.0
Bismuth 5.0
Minocycline 5.0
Neurotensin 5.0
1H-pyrazole 4.9
PID 4.9
PPI 4.9
Diclofenac 4.9
PID 4.9
Epigallocatechin gallate 4.9
Curcumin 4.8
4-AP 4.8
Sialic acid 4.8
5-methylisoxazole 4.8
Alizarin 4.8
Hoechst 33342 4.7
1H-pyrazole 4.7
Berberine 4.6
AEA 4.6
APAP 4.5
Titanium dioxide 4.5
Thymidine 4.5
DTPA 4.5
isoquinoline 4.4
Resveratrol 4.4
Cyt 4.4
TMA 4.3
Amide 4.3
Catechol 4.3
1H-indole 4.3
DMS 4.3
Gemcitabine 4.2
CCP 4.2
Gemcitabine 4.2
1H-imidazole 4.1
Cbl 4.1
TCP 4.1
TCP 4.1
Naloxone 4.0
MTT 4.0
TCP 4.0
TCP 4.0
boric acid 4.0
MSM 4.0
ATF 4.0
SPM 4.0
DTT 3.9
CPA 3.9
selenium 3.9
Wellcome 3.9
DTT 3.9
MEK 3.8
CPP 3.8
SET 3.8
rubidium 3.8
Chitosan 3.8
CPP 3.8
2-hydroxyethyl 3.8
2-hydroxyethyl 3.8
2-hydroxyethyl 3.8
2-hydroxyethyl 3.8
2-hydroxyethyl 3.8
2-hydroxyethyl 3.8
2-hydroxyethyl 3.8
vanadium 3.7
Cycloheximide 3.7
Vancomycin 3.7
chalcone 3.6
dUTP 3.6
isoxazole 3.6
Hematoxylin 3.6
aspartic acid 3.6
aspartic acid 3.5
Neu5Ac 3.5
Capsaicin 3.5
benzophenone 3.5
Phosphatidylinositol 3.5
2-hydroxyethyl 3.4
Oxytocin 3.4
more...