Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0279530 (bone cancer)
 1,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
osteosarcoma 259
Sep 71
Mol 71
Walker 51
p53 28
opioid receptor 22
TNF 21
caspase-3 20
glial fibrillary acidic protein 19
ERK 19
PI3K 18
collagen 17
IL-6 16
cytokine 15
AKT 15
osteogenic 14
RANKL 14
chemokine 13
NR2B 13
Bcl-2 12
nerve growth factor 12
alkaline phosphatase 12
p38 11
catenin 11
histone 10
EWS 10
HOS 10
tumor necrosis factor 10
calcitonin 10
MRI 10
matrix metalloproteinase 9
FLI1 9
ACS 9
RANK 8
MMP-9 8
osteoprotegerin 7
DRG 7
ERK1 7
extracellular signal-regulated kinase 7
TLR4 7
P2X7 7
MMP2 6
transient receptor potential vanilloid 1 6
vascular endothelial growth factor 6
CGRP 6
substance P 6
TRPV1 6
cytochrome c 6
UTR 6
dynorphin 6
MMP9 6
PARP 6
MEK 6
rhabdomyosarcoma 6
c-Jun 6
CCR2 6
p21 6
cage 6
ATP 6
CB2 5
SNS 5
IL-1 5
CXCL12 5
CXCR3 5
MAPK 5
CX3CR1 5
PKA 5
pRb 5
mTOR 5
PKC 5
MMP-2 5
NMDA receptor 5
P2X3 5
PBS 5
protein kinase B 4
serum albumin 4
RUNX2 4
JNK 4
Nanog 4
COX-2 4
PD-1 4
insulin 4
XIAP 4
hole 4
EphB2 4
fused 4
non-Hodgkin's lymphoma 4
CCL2 4
CD99 4
IL-18 4
p38 mitogen-activated protein kinase 4
proteasome 4
annexin V 4
Li-Fraumeni syndrome 4
epidermal growth factor receptor 4
c-Src 4
endoplasmic reticulum 4
caspase-8 4
IL-10 4
caspase-9 4
CXCL1 4
LC3 3
HMGB1 3
EphB1 3
sirtuin 1 3
c-Myc 3
tartrate-resistant acid phosphatase 3
WIN 3
CD4 3
CXCR4 3
RANTES) 3
Mcl-1 3
membrane-bound 3
phosphatidylinositol 3-kinase 3
tumor necrosis factor alpha 3
C18 3
CaMKII 3
RANTES 3
glycoprotein 3
Ki-67 3
membrane protein 3
fractalkine 3
lipopolysaccharide 3
Bak 3
threonine 3
estrogen receptor 3
OPG 3
CD133 3
ubiquitin 3
tropomyosin 3
NR1 3
member 1 3
proenkephalin 3
CXCL10 3
RhoA 3
signal transducer and activator of transcription 3 3
E2F1 3
histone deacetylase 3
receptor kinase 3
bone morphogenetic protein 3
Rho 3
metabotropic glutamate receptor 3
parathyroid hormone 3
Smad3 3
LPS 3
STAT3 3
EWSR1 3
cannabinoid receptor 3
IL-17 3
insulin-like growth factor 3
VEGF 3
CREB 2
ATR 2
TEM 2
high mobility group box 1 2
CFA 2
sodium channel 2
ECM 2
interleukin-6 2
monocyte chemoattractant protein-1 2
more...
Disease
bone cancer 1036
cancer 496
tumor 357
osteosarcoma 327
Osteosarcoma 207
Osteosarcoma 207
metastases 113
carcinoma 63
tumor growth 59
breast cancer 58
chronic pain 52
Ewing's sarcoma 49
sarcoma 49
bone metastases 47
osteoporosis 41
lung cancer 34
leukemia 34
prostate cancer 32
chondrosarcoma 31
primary tumor 22
Chondrosarcoma 21
Chondrosarcoma 21
tumor progression 19
tumorigenesis 17
melanoma 16
osteoarthritis 16
Frey 15
chordoma 15
bone disease 15
fibrosarcoma 15
rheumatoid arthritis 13
multiple myeloma 13
retinoblastoma 13
PDB 11
HOS 10
Sarcoma 10
childhood cancer 10
arthritis 10
Sarcoma 10
metastatic osteosarcoma 10
liver cancer 9
carcinogenesis 9
thyroid cancer 9
lung metastases 8
gastric cancer 8
cold 8
Hodgkin's disease 8
liver cancer 8
renal cancer 7
rare disease 7
neuropathy 7
cervical cancer 7
anemia 7
skin cancer 7
rhabdomyosarcoma 7
thrombocytopenia 6
colorectal cancer 6
aggressiveness 6
brain cancer 6
lymphoma 6
Blocking 6
neuroblastoma 6
Li-Fraumeni syndrome 6
SEM 5
pancreatic cancer 5
acute myeloid leukemia 5
colon cancer 5
osteomyelitis 5
cutaneous melanoma 5
osteolytic sarcoma 5
herpes simplex 5
ovarian cancer 4
bladder cancer 4
metastatic breast cancer 4
periodontitis 4
MCF 4
periosteum 4
peripheral neuropathy 4
suicide 4
B-cell lymphoma 4
diabetic neuropathy 4
hypercalcemia 4
non-Hodgkin's lymphoma 4
solid tumor 4
leukopenia 4
squamous cell carcinoma 4
chronic lymphocytic leukemia 3
dysphagia 3
middle ear 3
rectal cancer 3
connective tissue cancer 3
lymphosarcoma 3
chondroblastic osteosarcoma 3
tuberculosis 3
esophageal cancer 3
hypercalcemia of malignancy 3
endometrial cancer 3
cirrhosis 3
dysplasia 3
sickle cell disease 3
tumor angiogenesis 3
pathological fracture 3
otitis externa 3
neuroma 3
second cancer 3
tumor initiation 3
esophageal cancer 3
WT1 3
residual disease 3
neutropenia 3
chronic myeloid leukemia 2
bacterial infection 2
confusion 2
osteoma 2
osteomalacia 2
SCID 2
fits 2
osteopetrosis 2
ATM 2
aggression 2
chronic lymphocytic leukemia 2
periodontal disease 2
otitis media 2
oral cancer 2
hepatocellular carcinoma 2
incontinence 2
bronchogenic carcinoma 2
physical dependence 2
carcinomatosis 2
PTD 2
hepatitis 2
disinhibition 2
uterine cancer 2
myelodysplastic syndrome 2
dementia 2
asbestosis 2
malignant fibrous histiocytoma 2
TEM 2
hematologic malignancies 2
NAME 2
pulmonary tuberculosis 2
Cornelia de Lange syndrome 2
lung carcinoma 2
adenocarcinoma 2
aplastic anemia 2
depression 2
TEM 2
Lip 2
adenoma 2
myelosuppression 2
Alzheimer's disease 2
disseminated intravascular coagulation 2
cardiovascular disease 2
TCP 2
bone neoplasm 2
uterus 2
silicosis 2
chronic renal failure 2
vagina 2
epiphysis 2
more...
Symptom
pain 353
cancer pain 83
bone pain 61
analgesia 35
headache 5
discomfort 4
discomfort 4
breakthrough pain 3
low back pain 3
myalgia 2
nausea 2
fatigue 2
arthralgia 2
anesthesia 2
back pain 2
anorexia 2
constipation 2
otalgia 2
chronic cough 1
paresis 1
nausea and vomiting 1
Other pain 1
prominent nose 1
neuralgia 1
insomnia 1
chest pain 1
No pain 1
skin pain 1
torticollis 1
acute pain 1
Neuropathic pain 1
agitation 1
dry skin 1
Severe pain 1
collapse 1
Flare 1
Metastatic bone pain 1
physical symptom 1
dental pain 1
Drug
Monit 5
EHDP 5
lysine 5
Zoledronic acid 4
Zoledronic acid 3
GEO 3
CSF 3
G-CSF 2
ETS 2
Gelatin 2
citric acid 2
Cetuximab 2
ROS 2
Denosumab 2
CTX 1
Adriamycin 1
Teriparatide 1
APD 1
RAL 1
Rubitecan 1
Anakinra 1
Silica 1
Honey 1
Lumiracoxib 1
Capsicum 1
FAD 1
CAM 1
ZnO 1
PTH 1
Propentofylline 1
Gel 1
ADM 1
Epigallocatechin 1
TAK 1
Cilengitide 1
Barium sulfate 1
p75 1
TTC 1
PDL 1
Imatinib 1
Iguratimod 1
CTX 1
Exenatide 1
Celebrex 1
Simvastatin 1
ROC 1
NVP 1
IL-1ra 1
CTX 1
Cardiovasc 1
Enzyme
mitogen-activated protein kinase 28
ERK 27
protein kinase 19
caspase-3 15
luciferase 14
alkaline phosphatase 12
protein kinase C 12
ACS 9
PARP 7
MEK 6
caspase-8 4
proteasome 4
focal adhesion kinase 4
caspase-9 3
phosphatidylinositol 3-kinase 3
cytosine deaminase 3
NOS 2
P-glycoprotein 2
MMP 2
CaMKII 2
AMP-activated protein kinase 2
phosphoinositide 3-kinase 2
kinesin 2
MDP 2
AMPK 1
PKG 1
nicotinamide phosphoribosyltransferase 1
prostate-specific antigen 1
caspase-7 1
phosphatidylinositol-4,5-bisphosphate 3-kinase 1
ATPase 1
lactate dehydrogenase 1
DSR 1
topoisomerase 1
tyrosine hydroxylase 1
serine hydroxymethyltransferase 1
GRK5 1
trypsin 1
topoisomerase 1
phosphodiesterase 1
PDK1 1
acid phosphatase 1
prostate-specific membrane antigen 1
collagenase 1
polo-like kinase 1 1
APC 1
sphingosine kinase 1
GSK 1
AMPK 1
thymidine kinase 1
superoxide dismutase 1
carboxypeptidase E 1
caspase-7 1
NO synthase 1
KLK7 1
thymidylate synthase 1
reverse transcriptase 1
deaminase 1
lysyl oxidase 1
catalase 1
methylthioadenosine phosphorylase 1
RNA polymerase 1
kallikrein 1
Compound
Dec 74
Clin 38
DNA 33
calcium 28
oxygen 25
TNF 21
water 18
MTT 17
phosphate 16
iron 12
selenium 11
glutamate 9
ACS 9
Adriamycin 9
ACS 9
titanium 9
nitrogen 8
silver 8
Morphine 8
ADR 8
sodium 7
MEK 6
strontium 6
Curcumin 6
ATP 6
cAMP 6
DTPA 5
lysine 5
glucose 5
potassium 5
EHDP 5
hydrogen 5
methionine 4
APAP 4
Asp 4
aspartic acid 4
CaO 4
NH2 4
aspartic acid 4
threonine 4
zinc 4
aspartic acid 4
bromide 4
aspartic acid 4
salt 4
vitamin D 4
MNNG 3
Resveratrol 3
MDA 3
Pac 3
ASA 3
alanine 3
serine 3
DMSO 3
vanadium 3
Oxycodone 3
iodine 3
dUTP 3
MK801 3
nitrate 3
acetic acid 3
tyrosine 3
Naringin 2
PEG 2
propionic acid 2
Chitosan 2
Lip 2
retinoic acid 2
NAD 2
TCP 2
2-hydroxyethyl 2
Cyt 2
PPI 2
tin 2
Hoechst 33342 2
2-hydroxyethyl 2
His 2
N-acetylcysteine 2
arginine 2
Gelsemine 2
2-hydroxyethyl 2
propionic acid 2
TCP 2
ADP-ribose 2
DDP 2
cysteine 2
2-hydroxyethyl 2
carbonate 2
copper 2
Naringin 2
NMDA 2
sulfate 2
isoquinoline 2
2,4-dichlorophenyl 2
Bufalin 2
TEM 2
2-hydroxyethyl 2
Melatonin 2
5-FU 2
formaldehyde 2
DAMGO 2
TCP 2
Panam 2
Etanercept 2
GTP 2
NCD 2
2-hydroxyethyl 2
2,4-dichlorophenyl 2
2-hydroxyethyl 2
Lactate 2
GABA 2
2-hydroxyethyl 2
GABA 2
Naloxone 2
TCP 2
Phe 1
Dithiothreitol 1
Ursolic acid 1
nickel 1
Catechol 1
proline 1
1H-indole 1
Sphingosine 1-phosphate 1
HAP 1
Neo 1
PTSM 1
Tomatidine 1
Tetrahydropalmatine 1
1H-pyrazole 1
1H-imidazole 1
cGMP 1
rubidium 1
PMA 1
glutamine 1
isoxazole 1
APT 1
silicon 1
1,3-dihydro-2H-benzimidazol-2-one 1
Oxytocin 1
Primatol 1
IBA 1
DMS 1
Gly 1
Topotecan 1
Primatol 1
Tris 1
5-HT 1
benzamide 1
Gemcitabine 1
DTT 1
Berberine 1
Capsaicin 1
Alendronate 1
chalcone 1
CCP 1
1,2-ethanediamine 1
1,2-ethanediamine 1
Thymidine 1
Iodo 1
Cbl 1
more...