Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0279530 (
bone cancer
)
1,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Numerous studies have suggested that
interleukin 11
(
IL-11
) has roles in human gastric, prostate and
bone cancer
and endometrial carcinoma. Hence, we evaluated the expression of
IL-11
in bladder cancer and the correlation of
IL-11
levels and clinico-pathological features. The expression of
IL-11
in primary human bladder cell culture, human bladder cancer cell lines, transitional cell carcinoma (TCC) and non-cancerous bladder tissues (NATs) were analyzed by western blotting. Enzyme-linked immunosorbent assay (ELISA) for urinary
IL-11
was performed to compare the
IL-11
levels in healthy subjects and subjects diagnosed with bladder cancer. Our study suggested that the expression of
IL-11
in human bladder cancer cell lines and TCC was downregulated compared with primary human bladder cell culture and matched NATs. We also demonstrated reduced urinary levels of
IL-11
in subjects with bladder cancer compared with healthy subjects. Furthermore, we revealed that the levels of
IL-11
were associated with tumor grade and stage. The results suggested that reduced levels of
IL-11
may play an important role in the carcinogenesis and progression of TCC. They also indicated that
IL-11
may be a promising predictor for prognosis of TCC.
...
PMID:Interleukin-11, an interleukin-6-like cytokine, is a promising predictor for bladder cancer prognosis. 2317 40
